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We have demonstrated that therapeutic administration of l-arginine (l-arg) (120mg/kg) at +2h of whole body hyperthermia (WBH) could rescue the mice from heatstroke-induced death. Studies were undertaken to elucidate the role of l-arg in the immunomodulation of the heat-stressed mice. Administration of l-arginine (l-arg), (120mg/kg, i.p.), at +2h of WBH, rescued the mice from heat-induced death and...
Studies were carried out to ascertain the efficacy of mild whole body hyperthermia (WBH) as a modifier of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) cytotoxicity in mice. Adult Swiss male mice, 6-8 weeks old, weighing about 25 g were exposed to mild WBH (39 o C, 1 h) in a precision temperature controlled environmental chamber maintained at 50-60% relative humidity. Twenty-four hours after...
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