Search results for: David E. Purdy

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article

Anteroposterior perfusion heterogeneity in human hippocampus measured by arterial spin labeling MRI

Xiufeng Li, Subhendra N. Sarkar, David E. Purdy, Jeffrey S. Spence, more

Measurements of blood flow in the human hippocampus are complicated by its relatively small size, unusual anatomy and patterns of blood supply. Only a handful of arterial spin labeling (ASL) MRI articles have reported regional cerebral blood flow (rCBF) values for the human hippocampus. Numerous reports have found heterogeneity in a number of other physiological and biochemical parameters along the...

article

Quantitative proteomic analysis of HIV-1 infected CD4+ T cells reveals an early host response in important biological pathways: Protein synthesis, cell proliferation, and T-cell activation

Arti T. Navare, Pavel Sova, David E. Purdy, Jeffrey M. Weiss, more

Virology > 2012 > 429 > 1 > 37-46

Human immunodeficiency virus (HIV-1) depends upon host-encoded proteins to facilitate its replication while at the same time inhibiting critical components of innate and/or intrinsic immune response pathways. To characterize the host cell response on protein levels in CD4+ lymphoblastoid SUP-T1 cells after infection with HIV-1 strain LAI, we used mass spectrometry (MS)-based global quantitation with...

article

Proteome and computational analyses reveal new insights into the mechanisms of hepatitis C virus–mediated liver disease posttransplantation

Deborah L. Diamond, Alexei L. Krasnoselsky, Kristin E. Burnum, Matthew E. Monroe, more

Hepatology > 56 > 1 > 28 - 38

Liver transplant tissues offer the unique opportunity to model the longitudinal protein abundance changes occurring during hepatitis C virus (HCV)‐associated liver disease progression in vivo. In this study, our goal was to identify molecular signatures, and potential key regulatory proteins, representative of the processes influencing early progression to fibrosis. We performed global protein profiling...

article

Improved quantification of brain perfusion using FAIR with active suppression of superior tagging (FAIR ASST)

Xiufeng Li, Subhendra N. Sarkar, David E. Purdy, Robert W. Haley, more

Journal of Magnetic Resonance Imaging > 34 > 5 > 1037 - 1044

Purpose:To address two problems for perfusion studies in the middle or inferior brain regions: (1) to reduce venous artifacts due to the intrinsic superior labeling of FAIR; (2) to alleviate the discrepancy of the existence of both superior and inferior boluses, but with only the inferior bolus having a temporally defined bolus width with Q2TIPs or QUIPSS. Materials and Methods:Superior tagging suppression...

article

Secretion of noninfectious dengue virus-like particles and identification of amino acids in the stem region involved in intracellular retention of envelope protein

David E. Purdy, Gwong-Jen J. Chang

Virology > 2005 > 333 > 2 > 239-250

DNA plasmids that express flavivirus premembrane/membrane (prM/M) and envelope (E) proteins in the form of virus-like particles (VLPs) have an excellent potential as DNA vaccine candidates against virus infection. The plasmid-expressed VLPs are also useful as safe, noninfectious antigens in serodiagnostic assays. We have constructed plasmids containing the prM/M and E gene regions for DENV-1, -3,...

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Search results for: David E. Purdy

Anteroposterior perfusion heterogeneity in human hippocampus measured by arterial spin labeling MRI

Quantitative proteomic analysis of HIV-1 infected CD4+ T cells reveals an early host response in important biological pathways: Protein synthesis, cell proliferation, and T-cell activation

Proteome and computational analyses reveal new insights into the mechanisms of hepatitis C virus–mediated liver disease posttransplantation

Improved quantification of brain perfusion using FAIR with active suppression of superior tagging (FAIR ASST)

Secretion of noninfectious dengue virus-like particles and identification of amino acids in the stem region involved in intracellular retention of envelope protein

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INFONA - science communication portal

Search results for: David E. Purdy

Anteroposterior perfusion heterogeneity in human hippocampus measured by arterial spin labeling MRI

Quantitative proteomic analysis of HIV-1 infected CD4+ T cells reveals an early host response in important biological pathways: Protein synthesis, cell proliferation, and T-cell activation

Proteome and computational analyses reveal new insights into the mechanisms of hepatitis C virus–mediated liver disease posttransplantation

Improved quantification of brain perfusion using FAIR with active suppression of superior tagging (FAIR ASST)

Secretion of noninfectious dengue virus-like particles and identification of amino acids in the stem region involved in intracellular retention of envelope protein

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