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Pyruvate kinase (PK) deficiency is the commonest enzyme deficiency in the glycolytic pathway leading to hemolytic anemia secondary to decreased Adenosine Triphosphate (ATP) synthesis in the red cells. synthesis. PK deficiency due to mutations in the PKLR (1q21) gene leads to highly variable clinical presentation ranging from severe fetal anemia to well compensated anemia in adults. We describe dyserythropoiesis...
BackgroundThis retrospective cohort study analysed the clinical characteristics and outcomes of patients with childhood lymphoblastic lymphoma (LBL) treated in Shanghai, China.
ProcedureFrom 2001 to 2010, 108 evaluable patients ≤16 years of age who were newly diagnosed with biopsy‐proven LBL were treated with one of three treatment protocols: CCCG‐99, SCMC‐T‐NHL‐2002, or LBL‐CHOF‐2006.
ResultsTwo...
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