Ferran Prados

article

Comparison of multicenter MRI protocols for visualizing the spinal cord gray matter

Julien Cohen‐Adad, Eva Alonso‐Ortiz, Stephanie Alley, Maria Marcella Lagana, more

Magnetic Resonance in Medicine > 88 > 2 > 849 - 859

Purpose Spinal cord gray‐matter imaging is valuable for a number of applications, but remains challenging. The purpose of this work was to compare various MRI protocols at 1.5 T, 3 T, and 7 T for visualizing the gray matter. Methods In vivo data of the cervical spinal cord were collected from nine different imaging centers. Data processing consisted of automatically segmenting the spinal cord and...

article

Editorial for “MRI Findings of Arachnoiditis, Revisited. Is Classification Needed?”

Hugh G. Pemberton, Ferran Prados

Journal of Magnetic Resonance Imaging > 54 > 3 > 910 - 911

article

Sodium in the Relapsing–Remitting Multiple Sclerosis Spinal Cord: Increased Concentrations and Associations With Microstructural Tissue Anisotropy

Bhavana S. Solanky, Ferran Prados, Carmen Tur, Marios C. Yiannakas, more

Journal of Magnetic Resonance Imaging > 52 > 5 > 1429 - 1438

Background Associations between brain total sodium concentration, disability, and disease progression have recently been reported in multiple sclerosis. However, such measures in spinal cord have not been reported. Purpose To measure total sodium concentration (TSC) alterations in the cervical spinal cord of people with relapsing–remitting multiple sclerosis (RRMS) and a control cohort using sodium...

article

Hippocampal profiling: Localized magnetic resonance imaging volumetry and T2 relaxometry for hippocampal sclerosis

Sjoerd B. Vos, Gavin P. Winston, Olivia Goodkin, Hugh G. Pemberton, more

Epilepsia > 61 > 2 > 297 - 309

Objective Hippocampal sclerosis (HS) is the most common cause of drug‐resistant temporal lobe epilepsy, and its accurate detection is important to guide epilepsy surgery. Radiological features of HS include hippocampal volume loss and increased T2 signal, which can both be quantified to help improve detection. In this work, we extend these quantitative methods to generate cross‐sectional area and...

article

A 30‐Year Clinical and Magnetic Resonance Imaging Observational Study of Multiple Sclerosis and Clinically Isolated Syndromes

Karen K. Chung, Daniel Altmann, Frederik Barkhof, Katherine Miszkiel, more

Annals of Neurology > 87 > 1 > 63 - 74

Objective Clinical outcomes in multiple sclerosis (MS) are highly variable. We aim to determine the long‐term clinical outcomes in MS, and to identify early prognostic features of these outcomes. Methods One hundred thirty‐two people presenting with a clinically isolated syndrome were prospectively recruited between 1984 and 1987, and followed up clinically and radiologically 1, 5, 10, 14, 20,...

article

Longitudinal spinal cord atrophy in multiple sclerosis using the generalized boundary shift integral

Marcello Moccia, Ferran Prados, Massimo Filippi, Maria A. Rocca, more

Annals of Neurology > 86 > 5 > 704 - 713

Objective Spinal cord atrophy is a clinically relevant feature of multiple sclerosis (MS), but longitudinal assessments on magnetic resonance imaging using segmentation‐based methods suffer from measurement variability, especially in multicenter studies. We compared the generalized boundary shift integral (GBSI), a registration‐based method, with a standard segmentation‐based method. Methods Baseline...

article

Fast bound pool fraction mapping via steady‐state magnetization transfer saturation using single‐shot EPI

Marco Battiston, Torben Schneider, Francesco Grussu, Marios C. Yiannakas, more

Magnetic Resonance in Medicine > 82 > 3 > 1025 - 1040

Purpose To enable clinical applications of quantitative magnetization transfer (qMT) imaging by developing a fast method to map one of its fundamental model parameters, the bound pool fraction (BPF), in the human brain. Theory and Methods The theory of steady‐state MT in the fast‐exchange approximation is used to provide measurements of BPF, and bound pool transverse relaxation time (

T_{2}^{B}

). A sequence...

article

Relevance of time‐dependence for clinically viable diffusion imaging of the spinal cord

Francesco Grussu, Andrada Ianuş, Carmen Tur, Ferran Prados, more

Magnetic Resonance in Medicine > 81 > 2 > 1247 - 1264

Purpose Time‐dependence is a key feature of the diffusion‐weighted (DW) signal, knowledge of which informs biophysical modelling. Here, we study time‐dependence in the human spinal cord, as its axonal structure is specific and different from the brain. Methods We run Monte Carlo simulations using a synthetic model of spinal cord white matter (WM) (large axons), and of brain WM (smaller axons)....

article

A magnetic resonance multi-atlas for the neonatal rabbit brain

Sebastiano Ferraris, Johannes van der Merwe, Lennart Van Der Veeken, Ferran Prados, more

NeuroImage > 2018 > 179 > C > 187-198

The rabbit model has become increasingly popular in neurodevelopmental studies as it is best suited to bridge the gap in translational research between small and large animals. In the context of preclinical studies, high-resolution magnetic resonance imaging (MRI) is often the best modality to investigate structural and functional variability of the brain, both in vivo and ex vivo. In most of the...

article

Deep gray matter volume loss drives disability worsening in multiple sclerosis

Arman Eshaghi, Ferran Prados, Wallace J. Brownlee, Daniel R. Altmann, more

Annals of Neurology > 83 > 2 > 210 - 222

Objective Gray matter (GM) atrophy occurs in all multiple sclerosis (MS) phenotypes. We investigated whether there is a spatiotemporal pattern of GM atrophy that is associated with faster disability accumulation in MS. Methods We analyzed 3,604 brain high‐resolution T1‐weighted magnetic resonance imaging scans from 1,417 participants: 1,214 MS patients (253 clinically isolated syndrome [CIS], 708...

article

An optimized framework for quantitative magnetization transfer imaging of the cervical spinal cord in vivo

Marco Battiston, Francesco Grussu, Andrada Ianus, Torben Schneider, more

Magnetic Resonance in Medicine > 79 > 5 > 2576 - 2588

Purpose To develop a framework to fully characterize quantitative magnetization transfer indices in the human cervical cord in vivo within a clinically feasible time. Methods A dedicated spinal cord imaging protocol for quantitative magnetization transfer was developed using a reduced field‐of‐view approach with echo planar imaging (EPI) readout. Sequence parameters were optimized based in the...

article

Fast and reproducible in vivo T₁ mapping of the human cervical spinal cord

Marco Battiston, Torben Schneider, Ferran Prados, Francesco Grussu, more

Magnetic Resonance in Medicine > 79 > 4 > 2142 - 2148

Purpose To develop a fast and robust method for measuring T₁ in the whole cervical spinal cord in vivo, and to assess its reproducibility. Methods A spatially nonselective adiabatic inversion pulse is combined with zonally oblique‐magnified multislice echo‐planar imaging to produce a reduced field‐of‐view inversion‐recovery echo‐planar imaging protocol. Multi‐ inversion time data are obtained by...

article

Volumetric reconstruction from printed films: Enabling 30 year longitudinal analysis in MR neuroimaging

Michael Ebner, Karen K. Chung, Ferran Prados, M. Jorge Cardoso, more

NeuroImage > 2018 > 165 > C > 238-250

Hospitals often hold historical MR image data printed on films without being able to make it accessible to modern image processing techniques. Having the possibility to recover geometrically consistent, volumetric images from scans acquired decades ago will enable more comprehensive, longitudinal studies to understand disease progressions. In this paper, we propose a consistent framework to reconstruct...

article

Spinal cord grey matter segmentation challenge

Ferran Prados, John Ashburner, Claudia Blaiotta, Tom Brosch, more

NeuroImage > 2017 > 152 > C > 312-329

An important image processing step in spinal cord magnetic resonance imaging is the ability to reliably and accurately segment grey and white matter for tissue specific analysis. There are several semi- or fully-automated segmentation methods for cervical cord cross-sectional area measurement with an excellent performance close or equal to the manual segmentation. However, grey matter segmentation...

article

Longitudinal multiple sclerosis lesion segmentation: Resource and challenge

Aaron Carass, Snehashis Roy, Amod Jog, Jennifer L. Cuzzocreo, more

NeuroImage > 2017 > 148 > C > 77-102

In conjunction with the ISBI 2015 conference, we organized a longitudinal lesion segmentation challenge providing training and test data to registered participants. The training data consisted of five subjects with a mean of 4.4 time-points, and test data of fourteen subjects with a mean of 4.4 time-points. All 82 data sets had the white matter lesions associated with multiple sclerosis delineated...

article

A multi-time-point modality-agnostic patch-based method for lesion filling in multiple sclerosis

Ferran Prados, Manuel Jorge Cardoso, Baris Kanber, Olga Ciccarelli, more

NeuroImage > 2016 > 139 > C > 376-384

Multiple sclerosis lesions influence the process of image analysis, leading to tissue segmentation problems and biased morphometric estimates. Existing techniques try to reduce this bias by filling all lesions as normal-appearing white matter on T1-weighted images, considering each time-point separately. However, due to lesion segmentation errors and the presence of structures adjacent to the lesions,...

chapter

An Automatic Correction Tool for Relational Algebra Queries

Josep Soler, Imma Boada, Ferran Prados, Jordi Poch, more

Lecture Notes in Computer Science > Computational Science and Its Applications – ICCSA 2007 > Workshop on Wireless and Ad-Hoc Networking (WAD 7) > 861-872

Relational algebra is one of the main topics covered in undergraduate computer science database courses. In this paper, we present a web-based tool designed to automatically correct relational algebra queries. The tool is integrated in a more general e-learning environment and is used to reinforce teaching and learning on introductory database courses. A teacher enters relational algebra problems...

chapter

A Web-Based Tool for Entity-Relationship Modeling

Ferran Prados, Imma Boada, Josep Soler, Jordi Poch

Lecture Notes in Computer Science > Computational Science and Its Applications - ICCSA 2006 > Technical Session on Web Based Learning (WBL 2006) > 364-372

A web-based tool developed to automatically correct conceptual database schema is presented. This tool has been integrated into a more general e-learning platform and is used to reinforce teaching and learning on introductory database courses. This platform assigns to each student a set of database problems selected from a common repository. The student has to design a entity-relationship schema and...

article

Measuring brain atrophy with a generalized formulation of the boundary shift integral

Ferran Prados, Manuel Jorge Cardoso, Kelvin K. Leung, David M. Cash, more

Neurobiology of Aging > 2015 > 36 > Supplement 1 > S81-S90

Brain atrophy measured using structural magnetic resonance imaging (MRI) has been widely used as an imaging biomarker for disease diagnosis and tracking of pathologic progression in neurodegenerative diseases. In this work, we present a generalized and extended formulation of the boundary shift integral (gBSI) using probabilistic segmentations to estimate anatomic changes between 2 time points. This...

article

Information-Theoretic Approach for Automated White Matter Fiber Tracts Reconstruction

Ferran Prados, Imma Boada, Miquel Feixas, Alberto Prats-Galino, more

Neuroinformatics > 2012 > 10 > 3 > 305-318

Fiber tracking is the most popular technique for creating white matter connectivity maps from diffusion tensor imaging (DTI). This approach requires a seeding process which is challenging because it is not clear how and where the seeds have to be placed. On the other hand, to enhance the interpretation of fiber maps, segmentation and clustering techniques are applied to organize fibers into anatomical...

INFONA - science communication portal

Search results for: Ferran Prados

Comparison of multicenter MRI protocols for visualizing the spinal cord gray matter

Editorial for “MRI Findings of Arachnoiditis, Revisited. Is Classification Needed?”

Sodium in the Relapsing–Remitting Multiple Sclerosis Spinal Cord: Increased Concentrations and Associations With Microstructural Tissue Anisotropy

Hippocampal profiling: Localized magnetic resonance imaging volumetry and T2 relaxometry for hippocampal sclerosis

A 30‐Year Clinical and Magnetic Resonance Imaging Observational Study of Multiple Sclerosis and Clinically Isolated Syndromes

Longitudinal spinal cord atrophy in multiple sclerosis using the generalized boundary shift integral

Fast bound pool fraction mapping via steady‐state magnetization transfer saturation using single‐shot EPI

Relevance of time‐dependence for clinically viable diffusion imaging of the spinal cord

A magnetic resonance multi-atlas for the neonatal rabbit brain

Deep gray matter volume loss drives disability worsening in multiple sclerosis

An optimized framework for quantitative magnetization transfer imaging of the cervical spinal cord in vivo

Fast and reproducible in vivo T₁ mapping of the human cervical spinal cord

Volumetric reconstruction from printed films: Enabling 30 year longitudinal analysis in MR neuroimaging

Spinal cord grey matter segmentation challenge

Longitudinal multiple sclerosis lesion segmentation: Resource and challenge

A multi-time-point modality-agnostic patch-based method for lesion filling in multiple sclerosis

An Automatic Correction Tool for Relational Algebra Queries

A Web-Based Tool for Entity-Relationship Modeling

Measuring brain atrophy with a generalized formulation of the boundary shift integral

Information-Theoretic Approach for Automated White Matter Fiber Tracts Reconstruction

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