Search results for: Irena Frydecka

Items from 1 to 20 out of 26 results

article

PD-1 gene polymorphic variation is linked with first symptom of disease and severity of relapsing-remitting form of MS

Edyta Pawlak-Adamska, Oskar Nowak, Lidia Karabon, Anna Pokryszko-Dragan, more

Journal of Neuroimmunology > 2017 > 305 > C > 115-127

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS), where inflammation, demyelination together with the axonopathy are the cardinal features on pathologic ground, with a combined genetic and environmental background.The associations of PD-1 single nucleotide polymorphisms (SNPs): PD-1.3 (in intron 4), PD-1.5 and PD-1.9 (both in exon 5) with clinical manifestation...

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Erratum to: CD28/CTLA-4/ICOS haplotypes confers susceptibility to Graves’ disease and modulates clinical phenotype of disease

Edyta Pawlak-Adamska, Irena Frydecka, Marek Bolanowski, Anna Tomkiewicz, more

Endocrine > 2017 > 57 > 1 > 189-189

The online version of the original article can be found at doi:10.1007/s12020-016-1096-1.

article

Intragenic Variations in BTLA Gene Influence mRNA Expression of BTLA Gene in Chronic Lymphocytic Leukemia Patients and Confer Susceptibility to Chronic Lymphocytic Leukemia

Lidia Karabon, Anna Partyka, Monika Jasek, Ewa Lech-Maranda, more

Archivum Immunologiae et Therapiae Experimentalis > 2016 > 64 > 1 > 137-145

The aim of this study was to determine the association between polymorphisms in gene encoding B- and T-lymphocyte attenuator (BTLA) and susceptibility to chronic lymphocytic leukemia (CLL) and their influence on mRNA expression of BTLA gene in T and B cells from CLL patients (pts.). The following BTLA single-nucleotide polymorphisms (SNPs): rs2705511, rs1982809, rs9288952, rs76844316, rs16859633,...

article

CD28/CTLA-4/ICOS haplotypes confers susceptibility to Graves’ disease and modulates clinical phenotype of disease

Edyta Pawlak-Adamska, Irena Frydecka, Marek Bolanowski, Anna Tomkiewicz, more

Endocrine > 2017 > 55 > 1 > 186-199

Graves’ disease, an autoimmune disease with heterogeneous symptoms including Graves’ orbitopathy, has a combined genetic/environmental background, where variations within CD28/CTLA-4/ICOS genes are considered as disease markers.Association of CD28c.17+3T>C(rs3116496), CTLA-4g.319C>T(rs5742909), CTLA-4c.49A>G(rs231775), CTLA-4g.*642AT(8_33), CT60(rs3087243), Jo31(rs11571302), ICOSc.1554+4GT(8_15)...

article

Association of 3′ nearby gene BTLA polymorphisms with the risk of renal cell carcinoma in the Polish population

Anna Partyka, Krzysztof Tupikowski, Anna Kolodziej, Romuald Zdrojowy, more

Urologic Oncology: Seminars and Original Investigations > 2016 > 34 > 9 > 419.e13-419.e19

T cells play an important role in antitumor immunity, and molecules regulating T-cell activity could influence cancer susceptibility. The distinct role of coinhibitory receptors in immunosurveillance has been considered. B- and T-lymphocyte attenuator (BTLA) is one of these receptors, which negatively regulate immune responses. The aim of this study was to investigate the association between BTLA...

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CTLA-4 affects expression of key cell cycle regulators of G0/G1 phase in neoplastic lymphocytes from patients with chronic lymphocytic leukaemia

Lidia Ciszak, Irena Frydecka, Dariusz Wolowiec, Aleksandra Szteblich, more

Clinical and Experimental Medicine > 2016 > 16 > 3 > 317-332

Previously, we showed that cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) is overexpressed in chronic lymphocytic leukaemia (CLL) and its expression is correlated with the expression of the major regulators of G1 phase progression: cyclins D2 and D3, and cyclin-dependent kinase inhibitory protein 1 (p27^KIP1). In the present study, we blocked CTLA-4 on the surface of...

article

Patients with chronic lymphocytic leukaemia (CLL) differ in the pattern of CTLA-4 expression on CLL cells: the possible implications for immunotherapy with CTLA-4 blocking antibody

Lidia Ciszak, Irena Frydecka, Dariusz Wolowiec, Aleksandra Szteblich, more

Tumor Biology > 2016 > 37 > 3 > 4143-4157

Recently, systemic administration of a human monoclonal antibody directed against cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on circulating T cells in patients with chronic lymphocytic leukaemia (CLL) has been considered. Also, CLL cells have been shown to express CTLA-4, increased levels of which in the leukaemic compartment are a predictor of good clinical outcome. Since both...

article

Pretransplant donor and recipient CTLA-4 mRNA and protein levels as a prognostic marker for aGvHD in allogeneic hematopoietic stem cell transplantation

Lidia Karabon, Miroslaw Markiewicz, Agata Kosmaczewska, Anna Partyka, more

Immunology Letters > 2015 > 165 > 1 > 52-59

Cytotoxic T lymphocyte antigen-4 (CTLA-4) is an inhibitory T cells’ receptor essential for maintaining T cell homeostasis and immunotolerance. The role of the co-stimulatory pathway in development of aGvHD has been studied mostly in animal models. To the best of our knowledge, there are no published data on the role of CTLA-4 in pathogenesis of aGvHD after hematopoietic stem cell transplantation (HSCT)...

article

Gene Polymorphisms of Novel Immunotolerant Molecule BTLA: Distribution of Alleles, Genotypes and Haplotypes in Polish Caucasian Population

Anna Partyka, Dariusz Woszczyk, Tomasz Strzała, Anna Szczepańska, more

Archivum Immunologiae et Therapiae Experimentalis > 2015 > 63 > 1 > 73-78

B and T lymphocyte attenuator (BTLA) is one of the members of immunoglobulin superfamily which, like CTLA-4 and PD-1, is involved in down regulation of immune response. Despite the important role of BTLA in maintaining immune homeostasis, relatively little studies were devoted to the relationship of polymorphisms in the gene encoding BTLA with susceptibility to autoimmune disease and cancer. Moreover,...

article

A CT60G>A polymorphism in the CTLA-4 gene of the recipient may confer susceptibility to acute graft versus host disease after allogeneic hematopoietic stem cell transplantation

Lidia Karabon, Miroslaw Markiewicz, Anna Partyka, Edyta Pawlak-Adamska, more

Immunogenetics > 2015 > 67 > 5-6 > 295-304

T cell activation plays a crucial role in the development of acute graft versus host disease (aGvHD). Cytotoxic T cell antigen-4 (CTLA-4) is a co-inhibitory molecule that negatively regulates T cell activation, differentiation, and proliferation. Single-nucleotide polymorphisms (SNPs) in CTLA-4 gene may affect its function. Inconsistent observations have been reported regarding the associations of...

article

Exogenous IL-2 Controls the Balance in Th1, Th17, and Treg Cell Distribution in Patients with Progressive Rheumatoid Arthritis Treated with TNF-Alpha Inhibitors

Agata Kosmaczewska, Lidia Ciszak, Jerzy Swierkot, Aleksandra Szteblich, more

Inflammation > 2015 > 38 > 2 > 765-774

Interleukin-2 (IL-2) has been suggested to control Treg/Th17 balance. Recently, we reported a relationship of rheumatoid arthritis (RA) activity/progression with irreversible systemic Treg and Th1 defects including serum IL-2 shortage. Herein, we explore the role of in vitro stimulation with rIL-2 in the observed immune alterations reversal. Patients with stable or progressive RA were assigned to...

article

Associations between genes for killer immunoglobulin-like receptors and their ligands in patients with epithelial ovarian cancer

Sebastian Giebel, Agnieszka Boratyn-Nowicka, Lidia Karabon, Anna Jedynak, more

Human Immunology > 2014 > 75 > 6 > 508-513

Killer immunoglobulin-like receptors (KIRs) regulate function of NK cells and subsets of T cells. HLA class I molecules are ligands for inhibitory KIRs while specificity of activating KIRs is mainly unknown. Both KIR and HLA genotypes are highly polymorphic.In this study we analyzed associations of KIR and KIR ligand genes with the incidence and clinical course of epithelial ovarian cancer. DNA of...

article

Alterations in Both the Activatory and Inhibitory Potential of Peripheral Blood CD4+ T Cells in Rheumatoid Arthritis Patients Correlate with Disease Progression

Agata Kosmaczewska, Lidia Ciszak, Jerzy Swierkot, Aleksandra Szteblich, more

Pathology & Oncology Research > 2014 > 20 > 2 > 235-243

The chronic nature of rheumatoid arthritis (RA) suggests immune dysfunction, including persistent systemic activation. Therefore, we evaluated the activatory and inhibitory potential as well as proliferative activity of peripheral blood (PB) CD4+ T cells from RA patients in different stages of the disease and after different therapeutic interventions. We found that CD4+ T cells from RA patients were...

article

Patients with the most advanced rheumatoid arthritis remain with Th1 systemic defects after TNF inhibitors treatment despite clinical improvement

Agata Kosmaczewska, Jerzy Swierkot, Lidia Ciszak, Aleksandra Szteblich, more

Rheumatology International > 2014 > 34 > 2 > 243-253

Systemic immune defects might reflect severely dysregulated control of chronic inflammation related to disease progression. Th17/Treg cell imbalance has been demonstrated to be involved in rheumatoid arthritis (RA) pathogenesis. Despite controversial results, a growing anti-inflammatory role in this process has been recently attributed to Th1 responses. The aim of the study was to estimate the extent...

article

rs2072135, a low‐penetrance variant for chronic lymphocytic leukaemia?

Georgina P. Sava, Helen E. Speedy, Maria Chiara Bernardo, Silvia Deaglio, more

British Journal of Haematology > 162 > 2 > 221 - 228

Recent multi‐stage genome‐wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) that are robustly associated with chronic lymphocytic leukaemia (CLL) risk. Given that most of these SNPs map to non‐coding regions of the genome, it suggests that the functional basis of many GWAS signals will be through differential gene expression. By referencing publically accessible...

article

PPARg2 Ala¹² variant protects against Graves' orbitopathy and modulates the course of the disease

Edyta Pawlak-Adamska, Jacek Daroszewski, Marek Bolanowski, Jolanta Oficjalska, more

Immunogenetics > 2013 > 65 > 7 > 493-500

Orbital fibroblast differentiation to adipocytes is a peroxisome proliferator-activated receptor g (PPARg)-dependent process essential for pathogenic tissue remodeling in Graves' orbitopathy (GO). PPARg2 Pro¹²Ala polymorphism modulates expression and/or function of the molecule encoded by this gene and is a promising locus of GO. Here, we analyzed associations of PPARg2 Pro¹²Ala with clinical manifestation...

article

Dysregulated Expression of Both the Costimulatory CD28 and Inhibitory CTLA-4 Molecules in PB T Cells of Advanced Cervical Cancer Patients Suggests Systemic Immunosuppression Related to Disease Progression

Agata Kosmaczewska, Dorota Bocko, Lidia Ciszak, Iwona Wlodarska-Polinska, more

Pathology & Oncology Research > 2012 > 18 > 2 > 479-489

Cervical cancer (CC) occurs more frequently in women who are immunosuppressed, suggesting that both local and systemic immune abnormalities may be involved in the evolution of the disease. Costimulatory CD28 and inhibitory CTLA-4 molecules expressed in T cells play a key role in the balanced immune responses. There has been demonstrated a relation between CD28, CTLA-4, and IFN genes in susceptibility...

article

Variations in Suppressor Molecule CTLA-4 Gene Are Related to Susceptibility to Multiple Myeloma in a Polish Population

Lidia Karabon, Edyta Pawlak-Adamska, Anna Tomkiewicz, Anna Jedynak, more

Pathology & Oncology Research > 2012 > 18 > 2 > 219-226

Various phenotype and functional T-cell abnormalities are observed in multiple myeloma (MM) patients. The aim of this study was to investigate the association between polymorphisms in the gene encoding cytotoxic T-lymphocyte antigen-4 (CTLA-4), a negative regulator of the T-lymphocyte immune response and susceptibility to multiple myeloma in a Polish population. Two hundred MM patients and 380 healthy...

article

CTLA-4, CD28, and ICOS gene polymorphism associations with non-small-cell lung cancer

Lidia Karabon, Edyta Pawlak, Anna Tomkiewicz, Anna Jedynak, more

Human Immunology > 2011 > 72 > 10 > 947-954

Polymorphisms in genes encoding CD28, ICOS, and CTLA-4 were demonstrated to be associated with susceptibility to malignancies. To the best of our knowledge, no study on this association has been performed in a Caucasian population for non-small-cell lung cancer (NSCLC). In the present work, we investigated the polymorphisms CTLA-4c.49A>G (rs231775), CTLA-4g.319C>T (rs5742909), CTLA-4g.*642AT(8_33),...

article

Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk

Dalemari Crowther‐Swanepoel, Maria Chiara Di Bernardo, Krzysztof Jamroziak, Lidia Karabon, more

British Journal of Haematology > 154 > 2 > 229 - 233

A genome‐wide association study of chronic lymphocytic leukaemia (CLL) suggested that common variants at 15q25.2 (rs783540) and 18q21.1 (rs1036935) influence CLL. To validate these associations and explore their relationship with CLL risk we genotyped case‐control datasets from Poland, UK and Italy totalling 1428 cases and 1920 controls. Combined data from these and previously genotyped series (2503...

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Search results for: Irena Frydecka

PD-1 gene polymorphic variation is linked with first symptom of disease and severity of relapsing-remitting form of MS

Erratum to: CD28/CTLA-4/ICOS haplotypes confers susceptibility to Graves’ disease and modulates clinical phenotype of disease

Intragenic Variations in BTLA Gene Influence mRNA Expression of BTLA Gene in Chronic Lymphocytic Leukemia Patients and Confer Susceptibility to Chronic Lymphocytic Leukemia

CD28/CTLA-4/ICOS haplotypes confers susceptibility to Graves’ disease and modulates clinical phenotype of disease

Association of 3′ nearby gene BTLA polymorphisms with the risk of renal cell carcinoma in the Polish population

CTLA-4 affects expression of key cell cycle regulators of G0/G1 phase in neoplastic lymphocytes from patients with chronic lymphocytic leukaemia

Patients with chronic lymphocytic leukaemia (CLL) differ in the pattern of CTLA-4 expression on CLL cells: the possible implications for immunotherapy with CTLA-4 blocking antibody

Pretransplant donor and recipient CTLA-4 mRNA and protein levels as a prognostic marker for aGvHD in allogeneic hematopoietic stem cell transplantation

Gene Polymorphisms of Novel Immunotolerant Molecule BTLA: Distribution of Alleles, Genotypes and Haplotypes in Polish Caucasian Population

A CT60G>A polymorphism in the CTLA-4 gene of the recipient may confer susceptibility to acute graft versus host disease after allogeneic hematopoietic stem cell transplantation

Exogenous IL-2 Controls the Balance in Th1, Th17, and Treg Cell Distribution in Patients with Progressive Rheumatoid Arthritis Treated with TNF-Alpha Inhibitors

Associations between genes for killer immunoglobulin-like receptors and their ligands in patients with epithelial ovarian cancer

Alterations in Both the Activatory and Inhibitory Potential of Peripheral Blood CD4+ T Cells in Rheumatoid Arthritis Patients Correlate with Disease Progression

Patients with the most advanced rheumatoid arthritis remain with Th1 systemic defects after TNF inhibitors treatment despite clinical improvement

rs2072135, a low‐penetrance variant for chronic lymphocytic leukaemia?

PPARg2 Ala¹² variant protects against Graves' orbitopathy and modulates the course of the disease

Dysregulated Expression of Both the Costimulatory CD28 and Inhibitory CTLA-4 Molecules in PB T Cells of Advanced Cervical Cancer Patients Suggests Systemic Immunosuppression Related to Disease Progression

Variations in Suppressor Molecule CTLA-4 Gene Are Related to Susceptibility to Multiple Myeloma in a Polish Population

CTLA-4, CD28, and ICOS gene polymorphism associations with non-small-cell lung cancer

Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk

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