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Early life is a period of unique sensitivity during which experience can confer enduring effects on brain structure and function. During early perinatal life the quality of the surrounding environment and experiences, in particular the parent–child relationship, is associated with emotional and cognitive development later in life. For instance, adverse early-life experience is correlated with an increased...
Corticosterone and exposure to stressful experiences have been reported to decrease hippocampal synaptic plasticity, in particular when relatively mild stimulation paradigms—presumably activating predominantly N-methyl-d-aspartate receptors—are being used. Using various stimulation paradigms and pharmacological approaches we tested therefore the hypothesis that elevated corticosterone levels, by activating...
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