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STAT5 transcription factors are essential regulators of differentiation, survival and proliferation during hematopoiesis. Hyperactive STAT5 signaling requires enhanced tyrosine phosphorylation (pYSTAT5), which is found in most hematopoietic cancers and is associated with negative prognosis. Importantly, recurrent gain-of-function STAT5 variants have been detected in different diseases with Peripheral...
Sepsis is initiated by the presence of bacteria, or their products (e.g. endotoxins), in the bloodstream. It still represents a major problem in health care due to high mortality rates and incomplete understanding of the molecular mechanisms driving the disease. The Janus kinase Tyk2 is part of the signal transduction cascade utilized by different cytokines that are crucial for innate and adaptive...
Tyrosine kinase 2 (TYK2) is a member of the Janus kinase (JAK) family. Loss of TYK2 reduces cytotoxicity of both natural killer (NK) and cytotoxic T cells (CTL) in tumour surveillance. In addition to the canonical cytokine receptor associated and enzymatic activities, JAKs function also non-canonical, i.e. kinase independent and/or scaffolding. Recently, hyperactive TYK2 has been assigned to leukaemia...
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