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Bioartificial livers (BAL) were designed as a bridge to maintain patients with liver failure until they recover or receive a liver transplant. In these devices, the patient’s blood or plasma is circulated extra-corporeally through a bioreactor that houses a metabolically active component, as isolated hepatic cells or cultured cells. In this work, we tested LMOs from rat liver. LMOs are tissue slices...
BAL devices constitute an innovative therapeutic approach currently accepted as a bridge to liver transplantation for patients with liver failure. Usually, the patient’s blood or plasma is circulated extra-corporeally through a bioreactor that houses a metabolically active component which performs the functions of the damaged liver. Among these, ammonia detoxification is crucial because the accumulation...