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Surround inhibition is a physiological mechanism to focus neuronal activity in the central nervous system. This so-called center-surround organization is well known in sensory systems, where central signals are facilitated and eccentric signals are inhibited in order to sharpen the contrast between them. There is evidence that this mechanism is relevant to skilled motor behavior, and it is deficient,...
The left dorsal premotor cortex (PMd) plays an important role in movement selection and is abnormally activated in imaging studies in patients with right-sided focal hand dystonia (FHD).The aims of this study were to assess the role of left PMd in patients with FHD and in the genesis of surround inhibition, which is deficient in FHD.Single- and paired-pulse transcranial magnetic stimulation (TMS)...
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