Search results for: Dorota Trzybulska

Items from 1 to 8 out of 8 results

article

Salivary levels and immunohistochemical expression of selected angiogenic factors in benign and malignant parotid gland tumours

Katarzyna Błochowiak, Jerzy Sokalski, Ewelina Golusińska, Dorota Trzybulska, more

Clinical Oral Investigations > 2019 > 23 > 3 > 995-1006

Objectives Angiogenesis underlies tumour growth and metastasis through hepatocyte growth factor (HGF), epithelial growth factor (EGF), and vascular endothelial growth factor (VEGF). The aim of this study was to determine the levels of VEGF, EGF, HGF, HGFR (hepatocyte growth factor receptor), and SRSF1 (serine-rich protein splicing factor-1) in patients with parotid gland tumours and in healthy controls...

article

Retrospective analysis of reactive hyperplastic lesions in the oral cavity

Justyna Farynowska, Katarzyna Błochowiak, Dorota Trzybulska, Marzena Wyganowska-Świątkowska

European Journal of Clinical and Experimental Medicine > 2018 > 2 > 92-96

Introduction. Reactive hyperplastic lesions of the oral cavity are non-neoplastic lesions that result from low-grade chronic irritation of the oral mucosa. Objectives. The aim of this study was to present the epidemiological characteristics of reactive lesions. Materials and methods. The study was a retrospective analysis of the medical records of 116 patients with reactive lesions. The tissue specimens...

article

Serum alarm antiproteases in systemic sclerosis patients

Anna Olewicz-Gawlik, Dorota Trzybulska, Katarzyna Graniczna, Barbara Kuznar-Kaminska, more

Human Immunology > 2017 > 78 > 9 > 559-564

Alarm antiproteases, i.e. secretory leukocyte protease inhibitor ad elafin, are key mediators in innate immune response and integrate innate and adaptive immunity systems. The aim of the study was to assess clinical significance of serum levels of alarm antiproteases, elafin and secretory leukocyte protease inhibitor (SLPI) in patients with systemic sclerosis (SSc). Twenty-eight patients with SSc,...

article

Serum microRNAs in male subfertility—biomarkers and a potential pathogenetic link to metabolic syndrome

Dorota Trzybulska, Johannes Bobjer, Aleksander Giwercman, Christos Tsatsanis

Journal of Assisted Reproduction and Genetics > 2017 > 34 > 10 > 1277-1282

Purpose The purpose of the study was to identify serum microRNAs providing a link between male subfertility and metabolic syndrome (MetS) and validate their diagnostic potential. Methods Sera were analyzed for fertility and MetS-related parameters in subfertile men (n = 79) and controls (n = 38). Literature review identified miR-155-5p, miR-122-5p, miR-200a-3p, and miR-200c-3p which previously were...

article

Role of CYP1A1 in the biological activity of methylated resveratrol analogue, 3,4,5,4′-tetramethoxystilbene (DMU-212) in ovarian cancer A-2780 and non-cancerous HOSE cells

Hanna Piotrowska-Kempisty, Agnieszka Klupczyńska, Dorota Trzybulska, Katarzyna Kulcenty, more

Toxicology Letters > 2017 > 267 > C > 59-66

The role of CYP1A1 and CYP1B1 enzymes in the biotransformation and biological activity of the methylated resveratrol analogue, 3,4,5,4′-tetramethoxystilbene (DMU-212) is still elusive. Our recently published data have shown that one of the metabolites of DMU-212, 3′-hydroxy-3,4,5,4′-tetramethoxystilbene (DMU-214) exerts more potent cytotoxic effects in A-2780 ovarian cancer cell line, as compared...

article

Corrigendum to “Quantitative analysis of elastase and cathepsin G mRNA levels in peripheral blood CD14+ cells from patients with rheumatoid arthritis” [Cell. Immunol. 292 (2014) 40–44]

Dorota Trzybulska, Anna Olewicz-Gawlik, Katarzyna Graniczna, Kajetan Kisiel, more

Cellular Immunology > 2015 > 296 > 2 > 155

article

Quantitative analysis of elastase and cathepsin G mRNA levels in peripheral blood CD14+ cells from patients with rheumatoid arthritis

Dorota Trzybulska, Anna Olewicz-Gawlik, Katarzyna Graniczna, Kajetan Kisiel, more

Cellular Immunology > 2014 > 292 > 1-2 > 40-44

In rheumatoid arthritis (RA) activity of serine proteases is an important factor contributing to destructive changes in the joints. The aim of this study was to compare elastase (ELANE) and cathepsin G (CTSG) mRNA levels in peripheral blood CD14 ⁺ cells obtained from RA patients, healthy subjects (HS) and patients with osteoarthritis (OA). CD14 ⁺ cells were isolated from peripheral...

article

Interleukin‐17 and interleukin‐23: importance in the pathogenesis of lung impairment in patients with systemic sclerosis

Anna Olewicz‐Gawlik, Aleksandra Danczak‐Pazdrowska, Barbara Kuznar‐Kaminska, Justyna Gornowicz‐Porowska, more

International Journal of Rheumatic Diseases > 17 > 6 > 664 - 670

AimT cell abnormalities with a focus on Th17 cells have been associated with the pathogenesis of systemic sclerosis (SSc) and interstitial lung disease (ILD). The aim of this study was to evaluate serum levels of interleukin (IL)‐17, IL‐21 and IL‐23 in SSc patients and to assess their relationship with ILD‐SSc. MethodsThirty‐eight patients with SSc and 39 healthy controls were recruited. Serum IL‐17,...

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