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We developed a sensitive, reliable, and accurate LC/ESI-MS/MS method for measurement of 3β-sulfooxy-7β-N-acetylglucosaminyl-5-cholen-24-oic acid and its glycine and taurine amides in urine. This atypical C 24 bile acid has been reported previously to be present in the urine of patients with Niemann–Pick Type C (NPC) disease. In the method, targeted analytes are concentrated at the front edge...