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In 1936 prostatic acid phosphatase (PAP) became the key serum marker for monitoring prostate cancer (PCa) treatment (1–3). Approximately 50 yr later, prostate-specific antigen (PSA) emerged as the most useful serum marker for PCa management followed a few years later by the watershed application for early detection. In spite of the many tumor marker candidates proposed and studied for over 50 yr,...
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