Search results for: Marta Cortes

Items from 1 to 12 out of 12 results

article

Neutrophil β₁ adrenoceptor blockade blunts stroke‐associated neuroinflammation

Agustín Clemente‐Moragón, Eduardo Oliver, Daniel Calle, Lorena Cussó, more

British Journal of Pharmacology > 180 > 4 > 459 - 478

Background and Purpose Reperfusion therapy is the standard of care for ischaemic stroke; however, there is a need to identify new therapeutic targets able to ameliorate cerebral damage. Neutrophil β₁ adrenoceptors (β1AR) have been linked to neutrophil migration during exacerbated inflammation. Given the central role of neutrophils in cerebral damage during stroke, we hypothesize that β1AR blockade...

article

Access to early‐phase clinical trials for children with relapsed and refractory neuroblastoma: A multicentre international study

Marta Cortes, Fernando Carceller, Alba Rubio‐San‐Simón, Sucheta J. Vaidya, more

Pediatric Blood & Cancer > 69 > 8 > n/a - n/a

Objectives Neuroblastoma is the most common extracranial tumour in children, and prognosis for refractory and relapsed disease is still poor. Early‐phase clinical trials play a pivotal role in the development of novel drugs. Ensuring adequate recruitment is crucial. The primary aim was to determine the rate of participation trials for children with refractory/relapsed neuroblastoma in two of the...

article

Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening

E. Robert McDonald, Antoine de Weck, Michael R. Schlabach, Eric Billy, more

Cell > 2017 > 170 > 3 > 577-592.e10

Elucidation of the mutational landscape of human cancer has progressed rapidly and been accompanied by the development of therapeutics targeting mutant oncogenes. However, a comprehensive mapping of cancer dependencies has lagged behind and the discovery of therapeutic targets for counteracting tumor suppressor gene loss is needed. To identify vulnerabilities relevant to specific cancer subtypes,...

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What if it Switched on the Sun? Exploring Creativity in a Brainstorming Session with Children Through a Vygotskyan Perspective

Marianne Kinnula, Tonja Molin-Juustila, Iván Sánchez Milara, Marta Cortes, more

Computer Supported Cooperative Work (CSCW) > 2017 > 26 > 4-6 > 423-452

We contribute in this study a first step in theory-based understanding on how creativity in collaborative design sessions relates to the elements that are present in a creative act. These elements include group composition, objects present, practices used, and previous knowledge of the participants. The context of this study was our search for lightweight methods for technology design with children,...

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Fibrin deposited in the Alzheimer's disease brain promotes neuronal degeneration

Marta Cortes-Canteli, Larissa Mattei, Allison T. Richards, Erin H. Norris, more

Neurobiology of Aging > 2015 > 36 > 2 > 608-617

Alzheimer's disease (AD) is the most common form of dementia and has no effective treatment. Besides the well-known pathologic characteristics, this disease also has a vascular component, and substantial evidence shows increased thrombosis as well as a critical role for fibrin(ogen) in AD. This molecule has been implicated in neuroinflammation, neurovascular damage, blood-brain barrier permeability,...

article

Towards User Support in Ubiquitous Learning Systems

Ekaterina Gilman, Ivan Sanchez Milara, Marta Cortes, Jukka Riekki

IEEE Transactions on Learning Technologies > 2015 > 8 > 1 > 55 - 68

New technologies enable novel types of learning activities that differ radically from traditional approach of visiting lectures and doing homework assignments. Namely, these technologies support transforming our everyday environments into learning environments. This concept is referred to in the literature as ubiquitous learning. Enriching ubiquitous learning systems with adaptive functionality facilitates...

article

CCAAT/enhancer binding protein β directly regulates the expression of the complement component 3 gene in neural cells: implications for the pro-inflammatory effects of this transcription factor

Elena Hernandez-Encinas, Diana Aguilar-Morante, Marta Cortes-Canteli, Jose A Morales-Garcia, more

Journal of Neuroinflammation > 2015 > 12 > 1 > 1-16

Background The CCAAT/enhancer-binding protein β (C/EBPβ) is a transcription factor, which was first identified as a regulator of differentiation and inflammatory processes mainly in adipose tissue and liver; however, its function in the brain was largely unknown for many years. Previous studies from our laboratory indicated that C/EBPβ is implicated in inflammatory process and brain injury, since...

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Clinical characteristics and outcomes of diabetic patients who were hospitalised with 2009 pandemic influenza A H1N1 infection

Marta Cortes Garcia, Maria Jose Sierra Moros, Patricia Santa-Olalla Peralta, Valentin Hernandez-Barrera, more

Journal of Infection > 2012 > 64 > 2 > 218-224

To describe demographic and clinical data and outcomes of severe cases of 2009 pandemic influenza A H1N1 (pH1N1) infections for persons with diabetes.We selected all person with diabetes (N = 252) among severe laboratory confirmed cases reported to the Spanish Surveillance System for detection of pH1N1 from June through December, 2009. One patient without diabetes matched by age and sex was selected...

article

Peroxisome proliferator‐activated receptor γ ligands regulate neural stem cell proliferation and differentiation in vitro and in vivo

Jose A. Morales‐Garcia, Rosario Luna‐Medina, Clara Alfaro‐Cervello, Marta Cortes‐Canteli, more

Glia > 59 > 2 > 293 - 307

Peroxisome proliferator‐activated receptor gamma (PPARγ) belongs to a family of ligand‐activated nuclear receptors and its ligands are known to control many physiological and pathological situations. Its role in the central nervous system has been under intense analysis during the last years. Here we show a novel function for PPARγ in controlling stem cell expansion in the adult mammalian brain. Adult...

article

Fibrinogen and β-Amyloid Association Alters Thrombosis and Fibrinolysis: A Possible Contributing Factor to Alzheimer's Disease

Marta Cortes-Canteli, Justin Paul, Erin H. Norris, Robert Bronstein, more

Neuron > 2010 > 66 > 5 > 695-709

Alzheimer's disease (AD) is a neurodegenerative disorder in which vascular pathology plays an important role. Since the β-amyloid peptide (Aβ) is a critical factor in this disease, we examined its relationship to fibrin clot formation in AD. In vitro and in vivo experiments showed that fibrin clots formed in the presence of Aβ are structurally abnormal and resistant to degradation. Fibrin(ogen) was...

article

The CD8α Gene Locus Is Regulated by the Ikaros Family of Proteins

Nicola Harker, Taku Naito, Marta Cortes, Arnd Hostert, more

Molecular Cell > 2002 > 10 > 6 > 1403-1415

Ikaros family members are important regulatory factors in lymphocyte development. Here we show that Ikaros may play an important role in CD4 versus CD8 lineage commitment decisions by demonstrating: (1) that it binds to regulatory elements in the endogenous CD8α locus in vivo using thymocyte chromatin immunoprecipitations, (2) that Ikaros suppresses position effect variegation of transgenes driven...

article

Control of lymphocyte development by the Ikaros gene family

Marta Cortes, Esther Wong, Joseph Koipally, Katia Georgopoulos

Current Opinion in Immunology > 1999 > 11 > 2 > 167-171

Lymphoid cell differentiation relies on precisely orchestrated gene activation and repression events. Gene targeting studies have demonstrated crucial roles for the transcription factors Ikaros and Aiolos in regulating multiple stages of B and T cell development. Recent experiments suggest that Ikaros and Aiolos set B cell antigen-receptor (BCR)- and TCR-mediated signaling thresholds and that the...

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