Search results for: Y.J. Wang

Items from 1 to 20 out of 195 results

article

A high-sensitivity electrochemical aptasensor of carcinoembryonic antigen based on graphene quantum dots-ionic liquid-nafion nanomatrix and DNAzyme-assisted signal amplification strategy

J.Y. Huang, L. Zhao, W. Lei, W. Wen, more

Biosensors and Bioelectronics > 2018 > 99 > Complete > 28-33

In this work, we have developed an electrochemical aptasensor for high-sensitivity determination of carcinoembryonic antigen (CEA) based on lead ion (Pb²⁺)-dependent DNAzyme-assisted signal amplification and graphene quantum dot-ionic liquid-nafion (GQDs-IL-NF) composite film. We designed hairpin DNA containing CEA-specific aptamers and DNAzyme chains. In the presence of CEA, hairpin DNA recognized...

article

Rational design of Kluyveromyces marxianus ZJB14056 aldo-keto reductase KmAKR to enhance diastereoselectivity and activity

Y.J. Wang, B.B. Ying, W. Shen, R.C. Zheng, more

Enzyme and Microbial Technology > 2017 > 107 > Complete > 32-40

t-Butyl 6-cyano-(3R,5R)-dihydroxyhexanoate ((3R,5R)-1b) is a valuable chiral synthon of atorvastatin calcium. A novel NADPH-specific aldo-keto reductase (AKR) was identified from a thermotolerant yeast Kluyveromyces marxianus ZJB14056 by genome database mining, displaying t-butyl 6-cyano-(5R)-hydroxy-3-oxohexanoate ((5R)-1a) reducing activity and moderate diastereoselectivity (de_p~80.5%). Molecular...

article

Inhibition of the TGF-β1/Smad signaling pathway protects against cartilage injury and osteoarthritis in a rat model

Y.J. Wang, M. Shen, S. Wang, X. Wen, more

Life Sciences > 2017 > 189 > Complete > 106-113

Transforming growth factor-β1 (TGF-β1) in osteoblastic cells triggers pathological changes observed in osteoarthritis (OA). Thus, we hypothesized that the inhibition of the TGF-β1/Smad signaling pathway could act to protect against cartilage injury in rats with OA. After establishment of rat models induced by papain and L-cysteine, rats were subsequently assigned into the TβRI inhibitors, normal control...

article

Cortical compression rapidly trimmed transcallosal projections and altered axonal anterograde transport machinery

L.J. Chen, Y.J. Wang, G.F. Tseng

Neuroscience > 2017 > 362 > Complete > 79-94

Trauma and tumor compressing the brain distort underlying cortical neurons. Compressed cortical neurons remodel their dendrites instantly. The effects on axons however remain unclear. Using a rat epidural bead implantation model, we studied the effects of unilateral somatosensory cortical compression on its transcallosal projection and the reversibility of the changes following decompression. Compression...

article

Synthesis and anticancer properties of ruthenium (II) complexes as potent apoptosis inducers through mitochondrial disruption

D. Wan, B. Tang, Y.J. Wang, B.H. Guo, more

European Journal of Medicinal Chemistry > 2017 > 139 > Complete > 180-190

A new ligand MHPIP (MHPIP = 2-(1-methyl-1H-pyrazol-4-yl)-1H-imidazo[4,5-f][1,10]phenanthroline) and its three ruthenium (II) complexes [Ru(N-N)₂(MHPIP)](ClO₄)₂ (N-N = phen: 1,10-phenanthroline 1; dmp = 2,9-dimethyl-1,10-phenanthroline 2; ttbpy = 4,4'-ditertiarybutyl-2,2'-bipyridine 3) were synthesized and characterized. The cytotoxic activity in vitro was studied by MTT method. The complexes 1-3 show...

article

Simplified Predictive Nomogram By High-Dose Salvage Intensity Modulated Radiation Therapy after Radical Prostatectomy for Prostate Cancer

Y.J. Wang, C.Y. Huang, W.H. Hou, C.C. Wang, more

International Journal of Radiation Oncology, Biology, Physics > 2017 > 99 > 2 Supplement > E273-E274

article

Research on the appropriate way to transfer exogenous substances into chicken embryos

Y.l. WANG, K. JIN, N.n. HE, S.z. CHENG, more

Journal of Integrative Agriculture > 2017 > 16 > 10 > 2257-2263

Abstract: In biological research, chicken embryos are a classic experimental model for the exploration of the embryonic development and cell differentiation. Transferring exogenous substances into chicken embryos for producing medical antibodies has been widely used in the production practice. However, there are few studies about the effect of the different injection site and dosage on chicken embryos...

article

Role of LncRNA TUG1 in intervertebral disc degeneration and nucleus pulposus cells via regulating Wnt/β-catenin signaling pathway

J. Chen, Y.S. Jia, G.Z. Liu, Q. Sun, more

Biochemical and Biophysical Research Communications > 2017 > 491 > 3 > 668-674

Objective: To investigate the role of TUG1 in intervertebral disc degeneration (IDD) and human nucleus pulposus cells (NPCs) via regulating Wnt/β-catenin pathway. Methods: The study collected nucleus pulposus (NP) tissue samples from 30 patients with lumbar disc herniation (LDH) (Case group) and 18 patients with lumbar spine trauma (Control group). NPCs induced by TNF-α in vitro were divided into...

article

Short communication: Effects of an immunomodulatory feed additive on phagocytic capacity of neutrophils and relative gene expression in circulating white blood cells of transition Holstein cows

Z.H. Wu, Y. Yu, G.M. Alugongo, J.X. Xiao, more

Journal of Dairy Science > 2017 > 100 > 9 > 7549-7555

High-producing dairy cows typically experience immunosuppression with dysregulated neutrophil function (e.g., compromised phagocytosis) during the transition period (3 wk before to 3 wk after parturition), which is causally associated with increased risk of infections. Enhanced neutrophil immune competence has significant bearing with the wellbeing of transition dairy cattle. In the current study,...

article

Antidepressant-like effects of ginsenoside Rg2 in a chronic mild stress model of depression

Y. Ren, J.L. Wang, X. Zhang, H. Wang, more

Brain Research Bulletin > 2017 > 134 > Complete > 211-219

Major depression is a common neuropsychiatric disease with high lifetime prevalence and high incidence of suicide. This study aimed to evaluate the antidepressant effects of ginsenoside Rg2 in mice, and the possible mechanism was also determined. A single injection of both Rg2 (10 and 20mg/kg) and fluoxetine (positive control, 20mg/kg) induced notable antidepressant-like effects in the forced swim...

article

GAO's governor vessel-regulating and collaterals-unblocking technique for headache

X. XING, Y.j. WANG, L.h. CUI, Y.x. JI, more

World Journal of Acupuncture - Moxibustion > 2017 > 27 > 2 > 67-73

Governor vessel-regulating and collaterals-unblocking technique is a specific acupuncture therapy for treatment of headache of ''GAO's acupuncture-moxibustion academic school in Yanzhao land (around Hebei Province area)''. This method is a specific acupuncture therapy for treatment of various types of headache through combining GAO's four groups of empirical paired acupoints with governor vessel-regulating...

article

Metal-Organic Frameworks derived novel hierarchical durian-like nickel sulfide (NiS2) as an anode material for high-performance sodium-ion batteries

K.J. Zhu, G. Liu, Y.J. Wang, J. Liu, more

Materials Letters > 2017 > 197 > Complete > 180-183

An anode material for sodium-ion batteries, Ni-Metal-Organic Frameworks (MOFs)-derived nickel sulfide (NiS₂), is first reported. The synthesis strategy involves a novel method in which Ni-based MOFs is fabricated as precursor and then sulfured by sublimed sulfur in solid phase reaction. The as synthesized Ni-MOFs-derived NiS₂ shows a hierarchical durian-like nanostructure made of nanoparticles with...

article

Thickness-dependent a1/a2 domain evolution in ferroelectric PbTiO3 films

S. Li, Y.L. Zhu, Y.L. Tang, Y. Liu, more

Acta Materialia > 2017 > 131 > Complete > 123-130

Ferroelectric a₁/a₂ domain structure has great potentials in high dielectric capacitors and tunable microwave devices. Understanding its structure is crucial to better control the domain configurations for future applications. In this paper, PbTiO₃ thin films with variant thicknesses are deposited on (110)-oriented GdScO₃ substrates by Pulsed Laser Deposition (PLD) and investigated by using conventional...

article

Monitoring of wind effects on an instrumented low‐rise building during the landfall of a severe tropical storm

Q.S. Li, Y.J. Wang, J.C. Li

Structural Control and Health Monitoring > 24 > 6 > n/a - n/a

Tropical cyclone‐induced disasters cause significant economic losses and heavy causalities every year. Most of the casualties were caused by low‐rise buildings collapsing. This study aims to investigate the characteristics of tropical cyclone‐generated winds and evaluate the wind effects on a typical low‐rise building under tropical cyclone conditions through field measurements. In‐situ monitoring...

article

Microstructure and properties of an as-deposited and heat treated martensitic stainless steel fabricated by direct laser deposition

J.X. Fang, S.Y. Dong, Y.J. Wang, B.S. Xu, more

Journal of Manufacturing Processes > 2017 > 25 > Complete > 402-410

A steel of 16wt.% Cr-4.5wt.% Ni-1.6wt.% Mo-0.9wt.% B-0.6wt.% Mn-0.12wt.%C was fabricated by direct laser deposition (DLD), and its microstructure and material performance were investigated using transmission electron microscope (TEM), scanning electron microscopy (SEM), electrochemical workstation, hardness and impact test machines. The results show that solidification process of the Fe-Cr-Ni-Mo-B...

article

Abdominal Ultrasound Evaluation for a 3-Year-Old Man with Iron Deficiency Anemia and Abdominal Pain

Y.J. Wang

Ultrasound in Medicine & Biology > 2017 > 43 > Supplement 1 > S164

article

Magnetic properties of Mn2N0.86 (111) thin film grown on MgO (001) substrate by molecular beam epitaxy

G.L. Wang, M. Meng, W.Q. Zhou, Y.J. Wang, more

Materials Letters > 2016 > 184 > Complete > 291-293

(111)-oriented Mn₂N_0.86 thin films were fabricated on (001)-oriented MgO substrates by plasma-assisted molecular beam epitaxy. In-situ reflection high-energy electron diffraction and ex-situ X-ray diffraction results demonstrated that the (111)-oriented Mn₂N_0.86 thin films were single phase. The rocking curve manifested a very good crystallinity of Mn₂N_0.86 (111) phase and the thickness of the film...

article

Determination of two key parameters of a cohesive zone model for pipeline steels based on uniaxial stress-strain curve

Y.J. Wang, C.Q. Ru

Engineering Fracture Mechanics > 2016 > 163 > Complete > 55-65

It is widely believed that maximum traction of traction-separation law (TSL) and cohesive energy are the two key parameters of cohesive zone model (CZM). A method is presented in this paper to determine the two key CZM parameters for pipeline steels. The maximum traction of TSL is given by the critical stress defined based on damage at fracture point from the true stress-strain curve. And the other...

article

Intrinsic structural defects on medium range in metallic glasses

X. Huang, Z. Ling, Y.J. Wang, L.H. Dai

Intermetallics > 2016 > 75 > Complete > 36-41

To get insight into the structural defects on medium range in metallic glasses, molecular dynamic simulations on cavitation instability are carried out. It is found that micro voids are prone to nucleate at the sites where atomic clusters are loose packing on medium range. Close-up observation on atomic clusters around the nucleation site shows that there are two kinds of defects on medium range:...

article

Understanding the serrated flow and Johari-Goldstein relaxation of metallic glasses

M. Zhang, Y.J. Wang, L.H. Dai

Journal of Non-Crystalline Solids > 2016 > 444 > Complete > 23-30

An increasing tendency of serrated flow with increasing loading rate of a La-based (La) metallic glass (MG) with pronounced Johari-Goldstein relaxation in nanoindentation is investigated, which is abnormal compared to precedent observations where the serrated flow normally decays with increasing loading rate as discovered in the referenced Zr-based (Zr) and Pd-based (Pd) MGs. Based on systematic analysis,...

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INFONA - science communication portal

Search results for: Y.J. Wang

A high-sensitivity electrochemical aptasensor of carcinoembryonic antigen based on graphene quantum dots-ionic liquid-nafion nanomatrix and DNAzyme-assisted signal amplification strategy

Rational design of Kluyveromyces marxianus ZJB14056 aldo-keto reductase KmAKR to enhance diastereoselectivity and activity

Inhibition of the TGF-β1/Smad signaling pathway protects against cartilage injury and osteoarthritis in a rat model

Cortical compression rapidly trimmed transcallosal projections and altered axonal anterograde transport machinery

Synthesis and anticancer properties of ruthenium (II) complexes as potent apoptosis inducers through mitochondrial disruption

Simplified Predictive Nomogram By High-Dose Salvage Intensity Modulated Radiation Therapy after Radical Prostatectomy for Prostate Cancer

Research on the appropriate way to transfer exogenous substances into chicken embryos

Role of LncRNA TUG1 in intervertebral disc degeneration and nucleus pulposus cells via regulating Wnt/β-catenin signaling pathway

Short communication: Effects of an immunomodulatory feed additive on phagocytic capacity of neutrophils and relative gene expression in circulating white blood cells of transition Holstein cows

Antidepressant-like effects of ginsenoside Rg2 in a chronic mild stress model of depression

GAO's governor vessel-regulating and collaterals-unblocking technique for headache

Metal-Organic Frameworks derived novel hierarchical durian-like nickel sulfide (NiS2) as an anode material for high-performance sodium-ion batteries

Thickness-dependent a1/a2 domain evolution in ferroelectric PbTiO3 films

Monitoring of wind effects on an instrumented low‐rise building during the landfall of a severe tropical storm

Microstructure and properties of an as-deposited and heat treated martensitic stainless steel fabricated by direct laser deposition

Abdominal Ultrasound Evaluation for a 3-Year-Old Man with Iron Deficiency Anemia and Abdominal Pain

Magnetic properties of Mn2N0.86 (111) thin film grown on MgO (001) substrate by molecular beam epitaxy

Determination of two key parameters of a cohesive zone model for pipeline steels based on uniaxial stress-strain curve

Intrinsic structural defects on medium range in metallic glasses

Understanding the serrated flow and Johari-Goldstein relaxation of metallic glasses

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