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Background
The overproduction of IgE plays a critical role in the pathogenesis of allergy; the mechanism is unclear. Histone‐acetyltransferase (HAT) activities are required in gene transcription of a large number of molecules in the immune system of the body.
Objectives
This study tests a hypothesis that HAT Tat‐interactive protein 60 (Tip60) plays an important role in the initiation of IgE‐mediated...
BackgroundRecent immunological data demonstrated that dendritic cells preferentially recognize advanced glycation end product (AGE)‐modified proteins, upregulate expression of the receptor for AGE (RAGE), and consequently bias the immune response toward allergy.
MethodsPeanut extract was characterized by mass spectrometry (MS) to elucidate the specific residues and specific AGE modifications found...
To cite this article: Maleki SJ, Teuber SS, Cheng H, Chen D, Comstock SS, Ruan S, Schein CH. Computationally predicted IgE epitopes of walnut allergens contribute to cross‐reactivity with peanuts. Allergy 2011; 66: 1522–1529.
AbstractBackground: Cross‐reactivity between peanuts and tree nuts implies that similar immunoglobulin E (IgE) epitopes are present in their proteins.Objective: To determine...
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