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We studied the properties of inositol 1,4,5-trisphosphate receptors (InsP3Rs) in the membranes of the nuclear envelope of CNS neurons in rats. In cells with a maximum level of expression of InsP3Rs, (hippocampal and cerebellar neurons), these receptors are localized predominantly in the inner nuclear membrane. This allows us to hypothesize that the nuclear Ca2+ store is involved in regulation of expression...
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