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We report a photonic crystal (PC) biosensor that incorporates a porous TiO2 film to boost sensitivity by enlarged surface area and enhanced interaction with the resonant electromagnetic fields. In the context of sensing small molecule interactions with proteins, the porous PC achieves 3.7x larger resonant wavelength shifts than an equivalent nonporous structure. Utilizing the porous PC as the wavelength...
High throughput screening of protein-small molecule binding interactions using label-free optical biosensors is challenging, as the detected signals are often similar in magnitude to experimental noise. Here, we describe a novel self-referencing external cavity laser (ECL) biosensor approach that achieves high resolution and high sensitivity, while eliminating thermal noise with sub-picometer wavelength...
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