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Inactivation of von Hippel‐Lindau (VHL), a tumor suppressor gene is often associated with clear cell renal cell carcinoma (ccRCC). VHL inactivation leads to multitude of responses including enhanced growth factor signaling such as bFGF2, SDF‐1α, and HGF. Here, we have identified a novel VHL‐inducible gene, heparan sulfatase 2 (HSulf‐2) that attenuates heparan‐binding growth factor such as bFGF2 signaling...
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