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Nine dihydroartemisinin acetal dimers (6–14) with diversely functionalized linker units were synthesized and tested for in vitro antiprotozoal, anticancer and antimicrobial activity. Compounds 6, 7 and 11 [IC 50 : 3.0–6.7nM (D6) and 4.2–5.9nM (W2)] were appreciably more active than artemisinin (1) [IC 50 : 32.9nM (D6) and 42.5nM (W2)] against the chloroquine-sensitive (D6) and chloroquine-resistant...
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