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Activation of brain microglial cells, microgliosis, has been linked to methamphetamine (MA)–seeking behavior, suggesting that microglia could be a new therapeutic target for MA use disorder. Animal data show marked brain microglial activation following acute high‐dose MA, but microglial status in human MA users is uncertain, with one positron emission tomography (PET) investigation reporting massively...
Metabolites in the kynurenine pathway, generated by tryptophan degradation, are thought to play an important role in neurodegenerative disorders, including Alzheimer's and Huntington's diseases. In these disorders, glutamate receptor-mediated excitotoxicity and free radical formation have been correlated with decreased levels of the neuroprotective metabolite kynurenic acid. Here, we describe the...
Atmospherically derived surface films that cover impervious surfaces in cities, have areas comparable to that of atmospheric particulate matter (PM). The films compete with PM for sorption of volatile and semi-volatile organic compounds and alter the functionality of urban surfaces. The determination of surface-film composition is therefore vital to understanding their role in mediating chemical fate...
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