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Lactate metabolism variations are frequently encountered in mammalian cell culture processes, especially during process scale‐up. In this study, we took a multipronged approach to investigate the impact of pH, pCO2, osmolality, base addition, and mixing conditions on the observed lactate variations in a Chinese Hamster Ovary (CHO) fed‐batch process at 2,000 L scale. Two cultivating methods, CO2‐controlled...
In this work we present a systematic investigation of various failure mechanisms for thin-film platinum heater structures and interdigitated electrodes as components of a resistive type soot particle sensor. We study the role of stress-migration and electromigration and their interaction for the reliability of these sensors. The influence of a titanium adhesion layer and gases from the ambient atmosphere...
In this work we present a systematic investigation of failure mechanisms for thin-film platinum heater structures and interdigitated electrodes as components of a resistive type soot particle sensor. We study stress-migration and electromigration and effects of their interaction. Lifetime determination and SEM imaging are applied for samples which have experienced different load conditions to quantitatively...
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