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J. Neurochem. (2010) 114, 1659–1666.
AbstractVoltammetric analyses show that low (100–500 nM) doses of nicotine regulate striatal dopamine by inhibiting release evoked by a single stimulation to a greater extent than release evoked by high frequency stimulations. This frequency‐dependent inhibition is because of nicotine desensitizing heteromeric β2 subunit‐containing nicotinic acetylcholine receptor...
Intracranial self-stimulation (ICSS) activates the neural pathways that mediate reward, including dopaminergic terminal areas such as the nucleus accumbens (NAc). However, a direct role of dopamine in ICSS-mediated reward has been questioned. Here, simultaneous voltammetric and electrophysiological recordings from the same electrode reveal that, at certain sites, the onset of anticipatory dopamine...
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