Pyrroloxyls have been reported to exhibit very narrow EPR spectral lines, essential for in vivo imaging. En route to pyrroloxyls, we observed an unexpected Baeyer–Villiger rearrangement, leading to loss of aromaticity and formation of a 4,5-dihydro-1H-ketopyrrole.
The d-isomer of aspartate is both a substrate for glutamate transporters and an agonist of N-methyl-d-aspartate (NMDA) receptors. To monitor the behavior of these receptors and transporters in intact tissue we synthesized a new photo-labile analogue of d-aspartate, N-[(6-nitrocoumarin-7-yl)methyl]-d-aspartic acid (Ncm-d-aspartate). This compound was photolyzed rapidly (t 1/2 =0.11μs) by UV...
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