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Cocaine not only increases brain dopamine levels but also activates the sigma1 receptor (σ1R) that in turn regulates orexigenic receptor function. Identification of interactions involving dopamine D1 (D1R), ghrelin (GHS‐R1a), and σ1 receptors have been addressed by biophysical techniques and a complementation approach using interfering peptides. The effect of cocaine on receptor functionality was...
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