Search results for: Jeffrey A. Toretsky

Items from 1 to 20 out of 21 results

article

Afebrile S. aureus bacteremia in two patients with hemophagocytic lymphohistiocytosis receiving emapalumab/dexamethasone/etoposide

Jatinder K. Singh, Michael A. Terao, Susmita Sarangi, Jennifer Toth, more

Pediatric Blood & Cancer > 68 > 8 > n/a - n/a

article

Sarcoma‐Derived Extracellular Vesicles: Coupling Nanostructured Microchips with Covalent Chemistry Enables Purification of Sarcoma‐Derived Extracellular Vesicles for Downstream Functional Studies (Adv. Funct. Mater. 49/2020)

Jiantong Dong, Ryan Y. Zhang, Na Sun, Junhui Hu, more

Advanced Functional Materials > 30 > 49 > n/a - n/a

In article number 2003237, Meiping Zhao, Hsian‐Rong Tseng, Yazhen Zhu, and co‐workers present a device for the purification of Ewing sarcoma‐derived extracellular vesicles (EVs) by coupling LINGO‐1 antibodies with the covalent chemistry‐mediated EV capture/release mechanism using a nanostructure‐embedded microchip. The purified EVs can be internalized by recipient cells to transfer the mRNA cargoes,...

article

Coupling Nanostructured Microchips with Covalent Chemistry Enables Purification of Sarcoma‐Derived Extracellular Vesicles for Downstream Functional Studies

Jiantong Dong, Ryan Y. Zhang, Na Sun, Junhui Hu, more

Advanced Functional Materials > 30 > 49 > n/a - n/a

Tumor‐derived extracellular vesicles (EVs) play essential roles in intercellular communication during tumor growth and metastatic evolution. Currently, little is known about the possible roles of tumor‐derived EVs in sarcoma because the lack of specific surface markers makes it technically challenging to purify sarcoma‐derived EVs. In this study, a specific purification system is developed for Ewing...

article

Targeted inhibition of histone deacetylase leads to suppression of Ewing sarcoma tumor growth through an unappreciated EWS-FLI1/HDAC3/HSP90 signaling axis

Yan Ma, Michael Baltezor, Lian Rajewski, Jennifer Crow, more

Journal of Molecular Medicine > 2019 > 97 > 7 > 957-972

Ewing sarcoma (ES) are aggressive pediatric bone and soft tissue tumors driven by EWS-ETS fusion oncogenes, most commonly EWS-FLI1. Treatment of ES patients consists of up to 9 months of alternating courses of 2 chemotherapeutic regimens. Furthermore, EWS-ETS-targeted therapies have yet to demonstrate clinical benefit, thereby emphasizing a clinical responsibility to search for new therapeutic approaches...

chapter

Ewing’s Sarcoma Family of Tumors: Molecular Targets Need Arrows

Jeffrey A. Toretsky, Aykut Üren

Molecularly Targeted Therapy for Childhood Cancer > Solid Tumors > 373-400

Ewing’s Sarcoma Family of Tumors (ESFT) are highly malignant tumors of bone and soft tissue that occur in children, adolescents, and young adults (Arndt and Crist 1999; Toretsky 2003). Currently, the standard therapy for ESFT patients is a five-drug regimen that consists of alternating cycles of doxorubicin/vincristine/cyclophosphamide and etoposide/ifosfamide over the course of approximately 9 months...

article

Systemic levels of neuropeptide Y and dipeptidyl peptidase activity in patients with Ewing sarcoma—Associations with tumor phenotype and survival

Jason U. Tilan, Mark Krailo, Donald A. Barkauskas, Susana Galli, more

Cancer > 121 > 5 > 697 - 707

BACKGROUNDEwing sarcoma (ES) is driven by fusion of the Ewing sarcoma breakpoint region 1 gene (EWSR1) with an E26 transformation‐specific (ETS) transcription factor (EWS‐ETS), most often the Friend leukemia integration 1 transcription factor (FLI1). Neuropeptide Y (NPY) is an EWS‐FLI1 transcriptional target; it is highly expressed in ES and exerts opposing effects, ranging from ES cell death to angiogenesis...

article

Synovial sarcoma is a gateway to the role of chromatin remodeling in cancer

Stefan K. Zöllner, Claudia Rössig, Jeffrey A. Toretsky

Cancer and Metastasis Reviews > 2015 > 34 > 3 > 417-428

Patients afflicted with synovial sarcoma share the fate of other translocation positive sarcomas; the driver mutation for this cancer is known, yet no means to target the fusion protein SS18-SSX directly exist. Current chemotherapeutic regimens are minimally beneficial, particularly in patients with metastatic disease. SS18-SSX putatively promotes its oncogenic activity through protein-protein interactions...

article

Analysis of serum insulin growth factor‐1 concentrations in localized osteosarcoma: A children's oncology group study

Scott C. Borinstein, Donald A. Barkauskas, Mark Bernstein, Allen Goorin, more

Pediatric Blood & Cancer > 61 > 4 > 749 - 752

To investigate the role of insulin‐like growth factor‐1 (IGF‐1), in localized osteosarcoma, serum levels of IGF‐1, IGFBP‐2, and IGFBP‐3 were measured in 224 similarly treated, newly diagnosed patients. We demonstrated that younger patients had lower concentrations of IGF‐1 and IGFBP‐3 compared to older (P < 0.001) along with lower IGFBP‐3:IGF‐1 and IGFBP‐2:IGF‐1 ratios (P < 0.001). IGFBP‐2 did...

article

Design, synthesis and biological evaluation of ezrin inhibitors targeting metastatic osteosarcoma

Mikell Paige, George Kosturko, Güllay Bulut, Matthew Miessau, more

Bioorganic & Medicinal Chemistry > 2014 > 22 > 1 > 478-487

Respiratory failure due to pulmonary metastasis is the major cause of death for patients with osteosarcoma. However, the molecular basis for metastasis of osteosarcoma is poorly understood. Recently, ezrin, a member of the ERM family of proteins, has been associated with osteosarcoma metastasis to the lungs. The small molecule NSC 668394 was identified to bind to ezrin, inhibit in vitro and in vivo...

article

Loss of SS18-SSX1 Inhibits Viability and Induces Apoptosis in Synovial Sarcoma

Emily E. Carmody Soni, Silke Schlottman, Hayriye V. Erkizan, Aykut Uren, more

Clinical Orthopaedics and Related Research® > 2014 > 472 > 3 > 874-882

Background Most synovial sarcomas contain a chromosomal translocation t(X;18), which results in the formation of an oncoprotein SS18-SSX critical to the viability of synovial sarcoma. Questions/purposes We (1) established and characterized three novel synovial sarcoma cell lines and asked (2) whether inhibition of SS18-SSX1 decreases cell viability in these cell lines; and (3) whether reduction...

article

Valosin containing protein (VCP/p97) is a novel substrate for the protein tyrosine phosphatase PTPL1

Ogan D. Abaan, Wiljan Hendriks, Aykut Üren, Jeffrey A. Toretsky, more

Experimental Cell Research > 2013 > 319 > 1 > 1-11

Identification of Protein Tyrosine Phosphatase (PTP) substrates is critical in understanding cellular role in normal cells as well as cancer cells. We have previously shown that reduction of PTPL1 protein levels in Ewings sarcoma (ES) inhibit cell growth and tumorigenesis. Therefore, we sought to identify novel PTPL1 substrates that may be important for tumorigenesis. In this current work, we demonstrated...

article

Evaluation of arsenic trioxide by the pediatric preclinical testing program with a focus on Ewing sarcoma

Malcolm A. Smith, Min H. Kang, C. Patrick Reynolds, Raushan T. Kurmasheva, more

Pediatric Blood & Cancer > 59 > 4 > 753 - 755

Arsenic trioxide was tested against the PPTP in vitro panel (1.0 nM to 10 µM) and against the PPTP Ewing sarcoma in vivo panel administered intraperitoneally at a dose of 2.5 mg/kg daily × 5 per week for a planned treatment duration of 3 weeks. Arsenic trioxide showed a median relative IC₅₀ value of 0.9 µM, with Ewing sarcoma cell lines having IC₅₀ values similar to those of the remaining PPTP cell...

article

Investigation of the insulin‐like growth factor‐1 signaling pathway in localized Ewing sarcoma

Scott C. Borinstein, Donald A. Barkauskas, Mark Krailo, Daniel Scher, more

Cancer > 117 > 21 > 4966 - 4976

BACKGROUND:The insulin‐like growth factor‐1 (IGF‐1) signaling pathway plays an important role in the pathology of Ewing sarcoma (ES). Retrospective studies have suggested that levels of IGF‐1 and IGF binding protein 3 (IGFBP‐3) are correlated with the outcome of patients with ES. METHODS:The IGF‐1 signaling pathway was investigated prospectively in 269 patients who had localized, previously untreated...

article

IGF-1R targeted treatment of sarcoma

Jeffrey A Toretsky, Richard Gorlick

The Lancet Oncology > 2010 > 11 > 2 > 105-106

article

Juvenile xanthogranuloma in a child with previously unsuspected neurofibromatosis type 1 and juvenile myelomonocytic leukemia

Margarita Raygada, Diane C. Arthur, Alan S. Wayne, Owen M. Rennert, more

Pediatric Blood & Cancer > 54 > 1 > 173 - 175

The association of neurofibromatosis 1 (NF1), juvenile xanthogranulomas (JXG), and juvenile myelomonocytic leukemia (JMML) has been previously reported. We describe herein this triad in a Caucasian male infant with a pathogenic mutation in the NF1 gene (neurofibromin). The clinical course from initial presentation to final diagnosis is detailed; the physical features and hematologic characteristics...

article

PTPL1: a large phosphatase with a split personality

Ogan D. Abaan, Jeffrey A. Toretsky

Cancer and Metastasis Reviews > 2008 > 27 > 2 > 205-214

Protein tyrosine phosphatase, PTPL1, (also known as PTPN13, FAP-1, PTP-BAS, PTP1E) is a non-receptor type PTP and, at 270 kDa, is the largest phosphatase within this group. In addition to the well-conserved PTP domain, PTPL1 contains at least 7 putative macromolecular interaction domains. This structural complexity indicates that PTPL1 may modulate diverse cellular functions, perhaps exerting both...

article

Recombinant EWS-FLI1 Oncoprotein Activates Transcription ^†

Aykut Üren, Olga Tcherkasskaya, Jeffrey A. Toretsky

Biochemistry > 2004 > 43 > 42 > 13579 - 13589

article

Myoepithelioma metastatic to the orbit

Campbell Waldrop, Sajeev S. Kathuria, Jeffrey A. Toretsky, Chen-Chih J. Sun

American Journal of Ophthalmology > 2001 > 132 > 4 > 594-596

PURPOSE: To report a case of myoepithelioma metastatic to the orbit in an 11-year-old boy.METHODS: Interventional case report. An 11-year-old white male with a history of resection of a left thigh mass 10 months previously presented with a painless, rapid swelling of the left upper eyelid. Computed tomography scan and incisional biopsy of the orbital mass were performed.RESULTS: Immunohistochemical...

article

PBK/TOPK Is a Novel Mitotic Kinase Which Is Upregulated in Burkitt's Lymphoma and Other Highly Proliferative Malignant Cells

Michelle Simons-Evelyn, Kim Bailey-Dell, Jeffrey A. Toretsky, Douglas D. Ross, more

Blood Cells, Molecules and Diseases > 2001 > 27 > 5 > 825-829

ABSTRACTPBK/TOPK is a recently cloned serine/threonine kinase which is phosphorylated during mitosis. Earlier work indicated that this kinase is upregulated in a Burkitt's lymphoma cell line (GA-10). To determine whether PBK/TOPK is upregulated in other mitotically active neoplastic cell lines and tissues, Northern analysis was performed on a panel of malignant cell lines and on clinical samples from...

article

Expression of PAX3 in Ewing's Sarcoma Family of Tumors

Theodor W. Schulte, Jeffrey A. Toretsky, Elisabeth Ress, Lee Helman, more

Biochemical and Molecular Medicine > 1997 > 60 > 2 > 121-126

The Ewing's sarcoma family of tumors (ESFT) is the second most common pediatric malignancy originating in the bone and is characterized by the t(11; 22) translocation. PAX3, a member of the paired box family of genes, is expressed during embryonal development of neural crest cells and is involved in the t(2; 13) translocation found in alveolar rhabdomyosarcoma. Since ESFTs are believed to be derived...

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Search results for: Jeffrey A. Toretsky

Afebrile S. aureus bacteremia in two patients with hemophagocytic lymphohistiocytosis receiving emapalumab/dexamethasone/etoposide

Sarcoma‐Derived Extracellular Vesicles: Coupling Nanostructured Microchips with Covalent Chemistry Enables Purification of Sarcoma‐Derived Extracellular Vesicles for Downstream Functional Studies (Adv. Funct. Mater. 49/2020)

Coupling Nanostructured Microchips with Covalent Chemistry Enables Purification of Sarcoma‐Derived Extracellular Vesicles for Downstream Functional Studies

Targeted inhibition of histone deacetylase leads to suppression of Ewing sarcoma tumor growth through an unappreciated EWS-FLI1/HDAC3/HSP90 signaling axis

Ewing’s Sarcoma Family of Tumors: Molecular Targets Need Arrows

Systemic levels of neuropeptide Y and dipeptidyl peptidase activity in patients with Ewing sarcoma—Associations with tumor phenotype and survival

Synovial sarcoma is a gateway to the role of chromatin remodeling in cancer

Analysis of serum insulin growth factor‐1 concentrations in localized osteosarcoma: A children's oncology group study

Design, synthesis and biological evaluation of ezrin inhibitors targeting metastatic osteosarcoma

Loss of SS18-SSX1 Inhibits Viability and Induces Apoptosis in Synovial Sarcoma

Valosin containing protein (VCP/p97) is a novel substrate for the protein tyrosine phosphatase PTPL1

Evaluation of arsenic trioxide by the pediatric preclinical testing program with a focus on Ewing sarcoma

Investigation of the insulin‐like growth factor‐1 signaling pathway in localized Ewing sarcoma

IGF-1R targeted treatment of sarcoma

Juvenile xanthogranuloma in a child with previously unsuspected neurofibromatosis type 1 and juvenile myelomonocytic leukemia

PTPL1: a large phosphatase with a split personality

Recombinant EWS-FLI1 Oncoprotein Activates Transcription ^†

Myoepithelioma metastatic to the orbit

PBK/TOPK Is a Novel Mitotic Kinase Which Is Upregulated in Burkitt's Lymphoma and Other Highly Proliferative Malignant Cells

Expression of PAX3 in Ewing's Sarcoma Family of Tumors

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