Search results for: Lei O. Li

Items from 1 to 6 out of 6 results

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Propylisopropylacetic acid (PIA), a constitutional isomer of valproic acid, uncompetitively inhibits arachidonic acid acylation by rat acyl-CoA synthetase 4: A potential drug for bipolar disorder

Hiren R. Modi, Mireille Basselin, Ameer Y. Taha, Lei O. Li, more

BBA - Molecular and Cell Biology of Lipids > 2013 > 1831 > 4 > 880-886

Mood stabilizers used for treating bipolar disorder (BD) selectively downregulate arachidonic acid (AA) turnover (deacylation–reacylation) in brain phospholipids, when given chronically to rats. In vitro studies suggest that one of these, valproic acid (VPA), which is teratogenic, reduces AA turnover by inhibiting the brain long-chain acyl-CoA synthetase (Acsl)4 mediated acylation of AA to AA-CoA...

article

Valproate uncompetitively inhibits arachidonic acid acylation by rat acyl-CoA synthetase 4: Relevance to valproate's efficacy against bipolar disorder

Jakob A. Shimshoni, Mireille Basselin, Lei O. Li, Rosalind A. Coleman, more

BBA - Molecular and Cell Biology of Lipids > 2011 > 1811 > 3 > 163-169

Background: The ability of chronic valproate (VPA) to reduce arachidonic acid (AA) turnover in brain phospholipids of unanesthetized rats has been ascribed to its inhibition of acyl-CoA synthetase (Acsl)-mediated activation of AA to AA-CoA. Our aim was to identify a rat Acsl isoenzyme that could be inhibited by VPA in vitro. Methods: Rat Acsl3-, Acsl6v1- and Acsl6v2-, and Acsl4-flag proteins were...

article

Adipose Acyl-CoA Synthetase-1 Directs Fatty Acids toward β-Oxidation and Is Required for Cold Thermogenesis

Jessica M. Ellis, Lei O. Li, Pei-Chi Wu, Timothy R. Koves, more

Cell Metabolism > 2010 > 12 > 1 > 53-64

Long-chain acyl-CoA synthetase-1 (ACSL1) contributes 80% of total ACSL activity in adipose tissue and was believed to be essential for the synthesis of triacylglycerol. We predicted that an adipose-specific knockout of ACSL1 (Acsl1 ^A−/− ) would be lipodystrophic, but compared to controls, Acsl1 ^A−/− mice had 30% greater fat mass when fed a low-fat diet and gained weight normally when...

article

Acyl-CoA synthesis, lipid metabolism and lipotoxicity

Lei O. Li, Eric L. Klett, Rosalind A. Coleman

BBA - Molecular and Cell Biology of Lipids > 2010 > 1801 > 3 > 246-251

Although the underlying causes of insulin resistance have not been completely delineated, in most analyses, a recurring theme is dysfunctional metabolism of fatty acids. Because the conversion of fatty acids to activated acyl-CoAs is the first and essential step in the metabolism of long-chain fatty acid metabolism, interest has grown in the synthesis of acyl-CoAs, their contribution to the formation...

article

Cloning and functional characterization of a novel mitochondrial N-ethylmaleimide-sensitive glycerol-3-phosphate acyltransferase (GPAT2)

Shuli Wang, Douglas P. Lee, Nan Gong, Nicole M.J. Schwerbrock, more

Archives of Biochemistry and Biophysics > 2007 > 465 > 2 > 347-358

Glycerol-3-phosphate acyltransferase (GPAT) catalyzes the initial and rate-limiting step in glycerolipid synthesis. Several mammalian GPAT activities have been recognized, including N-ethylmaleimide (NEM)-sensitive isoforms in microsomes and mitochondria and an NEM-resistant form in mitochondrial outer membrane (GPAT1). We have now cloned a second mitochondrial isoform, GPAT2 from mouse testis. The...

article

Characterization of Recombinant Long-Chain Rat Acyl-CoA Synthetase Isoforms 3 and 6: Identification of a Novel Variant of Isoform 6

Cynthia G. Van Horn, Jorge M. Caviglia, Lei O. Li, Shuli Wang, more

Biochemistry > 2005 > 44 > 5 > 1635 - 1642

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Search results for: Lei O. Li

Propylisopropylacetic acid (PIA), a constitutional isomer of valproic acid, uncompetitively inhibits arachidonic acid acylation by rat acyl-CoA synthetase 4: A potential drug for bipolar disorder

Valproate uncompetitively inhibits arachidonic acid acylation by rat acyl-CoA synthetase 4: Relevance to valproate's efficacy against bipolar disorder

Adipose Acyl-CoA Synthetase-1 Directs Fatty Acids toward β-Oxidation and Is Required for Cold Thermogenesis

Acyl-CoA synthesis, lipid metabolism and lipotoxicity

Cloning and functional characterization of a novel mitochondrial N-ethylmaleimide-sensitive glycerol-3-phosphate acyltransferase (GPAT2)

Characterization of Recombinant Long-Chain Rat Acyl-CoA Synthetase Isoforms 3 and 6: Identification of a Novel Variant of Isoform 6

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