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In Escherichia coli, envelope stress is regulated by the alternative sigma factor σ E and the two-component regulatory system CpxRA. Both systems overlap in the transcriptional regulation of the htrA gene encoding a protease that degrades misfolded proteins in the periplasm. In Yersinia enterocolitica, HtrA is important for intracellular survival and full virulence in animal models. Here we...
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