Search results for: Dganit Danino

Items from 1 to 20 out of 69 results

article

Engineering pH‐Sensitive Stable Nanovesicles for Delivery of MicroRNA Therapeutics

Ariadna Boloix, Natalia Feiner‐Gracia, Mariana Köber, Javier Repetto, more

Small > 18 > 3 > n/a - n/a

MicroRNAs (miRNAs) are small non‐coding endogenous RNAs, which are attracting a growing interest as therapeutic molecules due to their central role in major diseases. However, the transformation of these biomolecules into drugs is limited due to their unstability in the bloodstream, caused by nucleases abundantly present in the blood, and poor capacity to enter cells. The conjugation of miRNAs to...

article

Directed Assembly of Multi‐Walled Nanotubes and Nanoribbons of Amino Acid Amphiphiles Using a Layer‐by‐Layer Approach

Kathrin Siegl, Luba Kolik‐Shmuel, Mingming Zhang, Sylvain Prévost, more

Chemistry – A European Journal > 27 > 23 > 6904 - 6910

Monodisperse unilamellar nanotubes (NTs) and nanoribbons (NRs) were transformed to multilamellar NRs and NTs in a well‐defined fashion. This was done by using a step‐wise approach in which self‐assembled cationic amino acid amphiphile (AAA) formed the initial NTs or NRs, and added polyanion produced an intermediate coating. Successive addition of cationic AAA formed a covering AAA layer, and by repeating...

article

RNA Delivery: A Combinatorial Library of Lipid Nanoparticles for RNA Delivery to Leukocytes (Adv. Mater. 12/2020)

Srinivas Ramishetti, Inbal Hazan‐Halevy, Ramesh Palakuri, Sushmita Chatterjee, more

Advanced Materials > 32 > 12 > n/a - n/a

In article number 1906128, Dan Peer and co‐workers describe the design and synthesis of novel ionizable lipids based on a linker strategy. The lipids are formulated into lipid nanoparticles and are screened for their gene silencing efficacies in cell‐culture models in vitro. Potent lipids are identified and analyzed for in vivo gene silencing efficacy in murine primary lymphocytes. Furthermore, no...

article

A Combinatorial Library of Lipid Nanoparticles for RNA Delivery to Leukocytes

Srinivas Ramishetti, Inbal Hazan‐Halevy, Ramesh Palakuri, Sushmita Chatterjee, more

Advanced Materials > 32 > 12 > n/a - n/a

Lipid nanoparticles (LNPs) are the most advanced nonviral platforms for small interfering RNA (siRNA) delivery that are clinically approved. These LNPs, based on ionizable lipids, are found in the liver and are now gaining much attention in the field of RNA therapeutics. The previous generation of ionizable lipids varies in linker moieties, which greatly influences in vivo gene silencing efficiency...

article

Controlled micelle conjugation via charged peptide amphiphiles

Thien Van Truong, Mihir Ghosh, Basavaprabhu Hosamani, Thekke V. Baiju, more

Journal of Peptide Science > 25 > 6 > n/a - n/a

Abstract We report the first demonstration of nonionic detergent micelle conjugation and phase separation using purpose‐synthesized, peptide amphiphiles, C₁₀‐(Asp)₅ and C₁₀‐(Lys)₅. Clustering is achieved in two different ways. Micelles containing the negatively charged peptide amphiphile C₁₀‐(Asp)₅ are conjugated (a) via a water‐soluble, penta‐Lys mediator or (b) to micelles containing the C₁₀‐(Lys)...

article

You Can Observe a Lot by Watching

Dganit Danino, Edward Egelman

Current Opinion in Colloid & Interface Science > 2018 > 34 > C > A1-A3

article

Direct imaging and computational cryo-electron microscopy of ribbons and nanotubes

Dganit Danino, Edward H. Egelman

Current Opinion in Colloid & Interface Science > 2018 > 34 > C > 100-113

Ribbons, filaments (fibers) and nanotubes are common structures in biological systems. They form by lipids, peptides and proteins, and are associated with many fundamental processes such as shaping membrane curvature, cell signaling, and protein function and dysfunction. Identical morphologies formed by natural or synthetic building blocks find numerous applications, e.g., in regenerative medicine,...

article

Synthesis of magnesium chloride nanoparticles by the water/oil nanoemulsion evaporation

Chani Mendelson-Mastey, Liraz Larush, Dganit Danino, Shlomo Magdassi

Colloids and Surfaces A: Physicochemical and Engineering Aspects > 2017 > 529 > C > 930-935

Dispersion of inorganic (magnesium chloride) nanoparticles in oil (octyl palmitate) was obtained by modifying a method based on solvent evaporation from nanometric droplets of water-in-oil nanoemulsion, which is usually used for obtaining organic nanoparticles. The particles size depends on the initial size of the emulsion droplets, and can be controlled by surfactant concentration and sonication...

article

Drug nanocarriers for cancer chemotherapy based on microemulsions: The case of Vemurafenib analog PLX4720

Ioanna Theochari, Maria Goulielmaki, Dganit Danino, Vassiliki Papadimitriou, more

Colloids and Surfaces B: Biointerfaces > 2017 > 154 > C > 350-356

Oil-in-water (O/W) microemulsions based on Tween 80 as the emulsifier and triacetin as the dispersed oil phase were formulated to be used as delivery vehicles of Vemurafenib analog PLX4720. PLX4720 is a lipophilic antitumor drug against various cancer types correlated with the BRAF^V600E mutation. The limits of the single-phase region corresponding to O/W microemulsions as described by ternary phase...

article

Membrane protein crystallization in micelles conjugated by nucleoside base-pairing: A different concept

Basavaprabhu Hosamani, Raju R. Kale, Hemlata Sharma, Ellen Wachtel, more

Journal of Structural Biology > 2016 > 195 > 3 > 379-386

The dearth of high quality, three dimensional crystals of membrane proteins, suitable for X-ray diffraction analysis, constitutes a serious barrier to progress in structural biology. To address this challenge, we have developed a new crystallization medium that relies on the conjugation of surfactant micelles via base-pairing of complementary hydrophobic nucleosides. Base-pairs formed at the interface...

article

1D Self-Assembly of Peptides and Lipids into Ribbons and Nanotubes

Dganit Danino, Luba Kolik

Biophysical Journal > 2016 > 110 > 3 Supplement 1 > 10a

article

Biocolloids and colloids in biology

Anna Stradner, Dganit Danino

Colloids and Surfaces B: Biointerfaces > 2016 > 137 > Complete > 1

article

Membrane Charge Directs the Outcome of F-BAR Domain Lipid Binding and Autoregulation

Charlotte F. Kelley, Emily M. Messelaar, Tania L. Eskin, Shiyu Wang, more

Cell Reports > 2015 > 13 > 11 > 2597-2609

F-BAR domain proteins regulate and sense membrane curvature by interacting with negatively charged phospholipids and assembling into higher-order scaffolds. However, regulatory mechanisms controlling these interactions are poorly understood. Here, we show that Drosophila Nervous Wreck (Nwk) is autoregulated by a C-terminal SH3 domain module that interacts directly with its F-BAR domain. Surprisingly,...

article

Editorial

Debora Berti, Dganit Danino

Colloids and Surfaces A: Physicochemical and Engineering Aspects > 2015 > 483 > C > 129

article

Cochleate characterization by cryogenic electron microscopy methods: Cryo-TEM and Cryo-SEM

Amit Hollander, Dganit Danino

Colloids and Surfaces A: Physicochemical and Engineering Aspects > 2015 > 483 > C > 187-192

Cochleates are lipid microstructures consisting of negatively charged phospholipid bilayers rolled up into cigar-like spirals, which are formed through the interactions with multivalent counter-ions used as bridging agents. This lipid system was shown to have potential as a drug carrier, primarily for oral delivery. In this study, we describe the structure of cochleates made of dioleoylphosphatidylserine...

article

Effect of temperature and loading on the structure of β-casein/ibuprofen assemblies

Tanya Turovsky, Irina Portnaya, Ellina Kesselman, Inbal Ionita-Abutbul, more

Journal of Colloid and Interface Science > 2015 > 449 > C > 514-521

β-Casein is a 24kDa amphiphilic and unstructured protein that self-assembles into small core–shell micelles at a wide range of concentrations, pH values and temperatures. We recently developed the micelles as nanocarriers for oral delivery of hydrophobic drugs. In this paper we examined the effect of the hydrophobic non-steroidal anti-inflammatory drug (NSAID) ibuprofen on the micellar structure,...

article

Internalization of Silica Nanoparticles into Fluid Liposomes: Formation of Interesting Hybrid Colloids

Raphael Michel, Ellina Kesselman, Tobias Plostica, Dganit Danino, more

Angewandte Chemie > 126 > 46 > 12649 - 12653

The formation of hybrid materials consisting of membrane‐coated silica nanoparticles (SiNPs) concentrated within small unilamellar vesicles (SUVs) of 1,2‐dioleoyl‐sn‐glycero‐3‐phosphocholine (DOPC) is described. They are formed by a simple self‐assembly process resulting from invagination of the SiNPs into the SUVs and subsequent vesicle fusion, thereby retaining an almost constant size. This process...

article

Innentitelbild: Internalization of Silica Nanoparticles into Fluid Liposomes: Formation of Interesting Hybrid Colloids (Angew. Chem. 46/2014)

Raphael Michel, Ellina Kesselman, Tobias Plostica, Dganit Danino, more

Angewandte Chemie > 126 > 46 > 12464 - 12464

Liposom‐Nanopartikel‐Hybridkolloide wurden durch Internalisierung von Quarznanopartikeln in fluide Liposome erhalten. In ihrer Zuschrift auf S. 12649 ff. zeigen M. Gradzielski, R. Michel et al., dass die Struktur dieser langzeitstabilen Hybridkolloide durch das anfängliche Mischverhältnis von Nanopartikeln zu Liposomen geprägt ist. Die Internalisierung kann unter Bedingungen verfolgt werden, unter...

article

Internalization of Silica Nanoparticles into Fluid Liposomes: Formation of Interesting Hybrid Colloids

Raphael Michel, Ellina Kesselman, Tobias Plostica, Dganit Danino, more

Angewandte Chemie International Edition > 53 > 46 > 12441 - 12445

article

Inside Cover: Internalization of Silica Nanoparticles into Fluid Liposomes: Formation of Interesting Hybrid Colloids (Angew. Chem. Int. Ed. 46/2014)

Raphael Michel, Ellina Kesselman, Tobias Plostica, Dganit Danino, more

Angewandte Chemie International Edition > 53 > 46 > 12266 - 12266

Liposome–nanoparticle hybrid colloids were obtained by internalization of silica nanoparticles into fluid liposomes. In their Communication on page 12441 ff., M. Gradzielski, R. Michel et al. show that the structure of these long‐time stable hybrid colloids is conveniently controlled by the initial mixing ratio of nanoparticles to liposomes. The internalization can be followed under conditions under...

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INFONA - science communication portal

Search results for: Dganit Danino

Engineering pH‐Sensitive Stable Nanovesicles for Delivery of MicroRNA Therapeutics

Directed Assembly of Multi‐Walled Nanotubes and Nanoribbons of Amino Acid Amphiphiles Using a Layer‐by‐Layer Approach

RNA Delivery: A Combinatorial Library of Lipid Nanoparticles for RNA Delivery to Leukocytes (Adv. Mater. 12/2020)

A Combinatorial Library of Lipid Nanoparticles for RNA Delivery to Leukocytes

Controlled micelle conjugation via charged peptide amphiphiles

You Can Observe a Lot by Watching

Direct imaging and computational cryo-electron microscopy of ribbons and nanotubes

Synthesis of magnesium chloride nanoparticles by the water/oil nanoemulsion evaporation

Drug nanocarriers for cancer chemotherapy based on microemulsions: The case of Vemurafenib analog PLX4720

Membrane protein crystallization in micelles conjugated by nucleoside base-pairing: A different concept

1D Self-Assembly of Peptides and Lipids into Ribbons and Nanotubes

Biocolloids and colloids in biology

Membrane Charge Directs the Outcome of F-BAR Domain Lipid Binding and Autoregulation

Editorial

Cochleate characterization by cryogenic electron microscopy methods: Cryo-TEM and Cryo-SEM

Effect of temperature and loading on the structure of β-casein/ibuprofen assemblies

Internalization of Silica Nanoparticles into Fluid Liposomes: Formation of Interesting Hybrid Colloids

Innentitelbild: Internalization of Silica Nanoparticles into Fluid Liposomes: Formation of Interesting Hybrid Colloids (Angew. Chem. 46/2014)

Internalization of Silica Nanoparticles into Fluid Liposomes: Formation of Interesting Hybrid Colloids

Inside Cover: Internalization of Silica Nanoparticles into Fluid Liposomes: Formation of Interesting Hybrid Colloids (Angew. Chem. Int. Ed. 46/2014)

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