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We critically re-examined the mechanisms that affect protein stability under crowding conditions. Much attention has been paid in recent years to the effects of molecular crowding on the properties of proteins in the cellular milieu. It has been suggested that volume exclusion disfavors the unfolded state since this is more expanded than the folded one, leading to an overall stabilizing effect. Experimental...
Microarray technology is a powerful tool for analyzing the expression of a large number of genes in parallel. A typical microarray image consists of a few thousands of spots which determine the level of gene expression in the sample. In this paper we propose a method which automatically addresses each spot area in the image. Initially, a preliminary segmentation of the image is produced using a template...
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