Search results for: Christopher J. Turner

Items from 1 to 16 out of 16 results

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Endothelium-derived fibronectin regulates neonatal vascular morphogenesis in an autocrine fashion

Christopher J. Turner, Kwabena Badu-Nkansah, Richard O. Hynes

Angiogenesis > 2017 > 20 > 4 > 519-531

Fibronectin containing alternatively spliced EIIIA and EIIIB domains is largely absent from mature quiescent vessels in adults, but is highly expressed around blood vessels during developmental and pathological angiogenesis. The precise functions of fibronectin and its splice variants during developmental angiogenesis however remain unclear due to the presence of cardiac, somitic, mesodermal and neural...

article

Discrete Event Simulation and Virtual Reality Use in Industry: New Opportunities and Future Trends

Christopher J. Turner, Windo Hutabarat, John Oyekan, Ashutosh Tiwari

IEEE Transactions on Human-Machine Systems > 2016 > 46 > 6 > 882 - 894

This paper reviews the area of combined discrete event simulation (DES) and virtual reality (VR) use within industry. While establishing a state of the art for progress in this area, this paper makes the case for VR DES as the vehicle of choice for complex data analysis through interactive simulation models, highlighting both its advantages and current limitations. This paper reviews active research...

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Integrin-α5β1 is not required for mural cell functions during development of blood vessels but is required for lymphatic-blood vessel separation and lymphovenous valve formation

Christopher J. Turner, Kwabena Badu-Nkansah, Denise Crowley, Arjan van der Flier, more

Developmental Biology > 2014 > 392 > 2 > 381-392

Integrin α5β1 is essential for vascular development but it remains unclear precisely where and how it functions. Here, we report that deletion of the gene encoding the integrin-α5 subunit (Itga5) using the Pdgfrb-Cre transgenic mouse line, leads to oedema, haemorrhage and increased levels of embryonic lethality. Unexpectedly, these defects were not caused by loss of α5 from Pdgfrb-Cre expressing mural...

article

Information flow in supply chain management: A review across the product lifecycle

Nikolaos Madenas, Ashutosh Tiwari, Christopher J. Turner, James Woodward

CIRP Journal of Manufacturing Science and Technology > 2014 > 7 > 4 > 335-346

The purpose of this review is to provide an analysis and comparison of publications identified in the area of information flow in supply chain management. Although review articles have extensively analysed supply chain management during the manufacturing phase of the product lifecycle, product development and service phases seems to be largely separated. Therefore a total of 132 journal articles were...

article

Diabetes-focused rotation's impact on student confidence and knowledge

Samuel L. Ellis, Wesley Nuffer, Christopher J. Turner

Currents in Pharmacy Teaching and Learning > 2012 > 4 > 3 > 174-179

To assess the impact of a diabetes-focused advanced pharmacy practice experience on students' diabetes-related confidence and knowledge. A survey tool was created, including 22 confidence and 30 knowledge questions centered on diabetes care. Students entering into a diabetes-focused advanced pharmacy practice experience (APPE) during rotation 7 served as the intervention group, whereas students...

article

Chemical shift anisotropy selective inversion

Marc A. Caporini, Christopher J. Turner, Anthony Bielecki, Robert G. Griffin

Journal of Magnetic Resonance > 2009 > 200 > 2 > 233-238

Magic angle spinning (MAS) is used in solid-state NMR to remove the broadening effects of the chemical shift anisotropy (CSA). In this work we investigate a technique that can reintroduce the CSA in order to selectively invert transverse magnetization. The technique involves an amplitude sweep of the radio frequency field through a multiple of the spinning frequency. The selectivity of this inversion...

article

In Situ Temperature-Jump Dynamic Nuclear Polarization: Enhanced Sensitivity in Two Dimensional ¹³ C− ¹³ C Correlation Spectroscopy in Solution

Chan-Gyu Joo, Andrew Casey, Christopher J. Turner, Robert G. Griffin

Journal of the American Chemical Society > 2009 > 131 > 1 > 12 - 13

article

Regulation of Angiogenesis by Eph–Ephrin Interactions

Sanne Kuijper, Christopher J. Turner, Ralf H. Adams

Trends in Cardiovascular Medicine > 2007 > 17 > 5 > 145-151

The large families of Eph receptor tyrosine kinases and their ephrin ligands transduce signals in a cell-cell contact-dependent fashion and thereby coordinate the growth, differentiation, and patterning of almost every organ and tissue. Eph–ephrin interactions can trigger a wide array of cellular responses, including cell adhesion, boundary formation, and repulsion. The exact mechanisms leading to...

article

Nuclear Magnetic Resonance Structural Studies and Molecular Modeling of Duplex DNA Containing Normal and 4‘-Oxidized Abasic Sites ^† ^, ^‡

Jingyang Chen, François-Yves Dupradeau, David A. Case, Christopher J. Turner, more

Biochemistry > 2007 > 46 > 11 > 3096 - 3107

article

Ephrin-B2 Controls Cell Motility and Adhesion during Blood-Vessel-Wall Assembly

Shane S. Foo, Christopher J. Turner, Susanne Adams, Amelia Compagni, more

Cell > 2006 > 124 > 1 > 161-173

New blood vessels are initially formed through the assembly or sprouting of endothelial cells, but the recruitment of supporting pericytes and vascular smooth muscle cells (mural cells) ensures the formation of a mature and stable vascular network. Defective mural-cell coverage is associated with the poorly organized and leaky vasculature seen in tumors or other human diseases. Here we report that...

article

High-Resolution Field-Cycling NMR Studies of a DNA Octamer as a Probe of Phosphodiester Dynamics and Comparison with Computer Simulation ^†

Mary F. Roberts, Qizhi Cui, Christopher J. Turner, David A. Case, more

Biochemistry > 2004 > 43 > 12 > 3637 - 3650

article

Molecular Dynamics of the Long Neurotoxin LSIII ^†

Peter J. Connolly, Alan S. Stern, Christopher J. Turner, Jeffrey C. Hoch

Biochemistry > 2003 > 42 > 49 > 14443 - 14451

article

Solution Structure of Co(III)-Bleomycin-OOH Bound to a Phosphoglycolate Lesion Containing Oligonucleotide: Implications for Bleomycin-Induced Double-Strand DNA Cleavage ^†

Silvia T. Hoehn, Hans-Dieter Junker, Richard C. Bunt, Christopher J. Turner, more

Biochemistry > 2001 > 40 > 20 > 5894 - 5905

article

Artifacts in Sensitivity-Enhanced HSQC

Christopher J. Turner, Peter J. Connolly, Alan S. Stern

Journal of Magnetic Resonance > 1999 > 137 > 1 > 281-284

Proton–proton coupling can generate artifacts in sensitivity-enhanced HSQC spectra. These artifacts appear as cross-peaks involving remote protons. They are caused by relayed coherence transfer during the back-transfer portion of the pulse sequence. We present a product operator analysis of artifact formation and experimental results which demonstrate that the magnitude of these artifacts can exceed...

article

A model of the structure of HOO-Co.bleomycin bound to d(CCAGTACTGG): recognition at the d(GpT) site and implications for double-stranded DNA cleavage

Dana E. Vanderwall, Siu Man Lui, Wei Wu, Christopher J. Turner, more

Chemistry & Biology > 1997 > 4 > 5 > 373-387

Background: The bleomycins (BLMs) are a family of natural products used clinically as antitumor agents. In the presence of their required cofactors, iron and oxygen, BLMs bind to and mediate single-stranded and double-stranded DNA cleavage. Recently, two dimensional nuclear magnetic resonance (2D NMR) spectroscopic studies and molecular modeling have provided a picture of how the hydroperoxide form...

article

Parallel implementations of convolution and moments algorithms on a multi-transputer system

Christopher J Turner, Virendrakumar C Bhavsar, Przemyslaw R Pochec

Microprocessors and Microsystems > 1995 > 19 > 5 > 283-290

This paper describes the implementations of convolution and regular moments on a transputer network. Discrete convolution is the principal spatial domain method for digital image enhancement. Moments are by far the most popular descriptors for image regions and boundary segments. Both convolution and moments are computationally expensive and difficult to accomplish in real time. To reduce computational...

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