Search results for: Roderic G. Eckenhoff

Items from 1 to 20 out of 48 results

article

Sex effects on behavioral markers of emergence from propofol and isoflurane anesthesia in rats

Mohammed Taghi Mansouri, Jonathan A. Fidler, Qing Cheng Meng, Roderic G. Eckenhoff, more

Behavioural Brain Research > 2019 > 367 > C > 59-67

Clinical studies have demonstrated sex-related differences in recovery from surgical anesthesia. This study aimed to characterize the emergence pattern following two anesthesia regimens in both sexes of rats.We considered six different markers of emergence from anesthesia: sigh, eye blinking, forelimb movement, mastication, neck extension, and recovery of the righting reflex (RORR). Spontaneous motor...

article

Sites and Functional Consequence of Alkylphenol Anesthetic Binding to Kv1.2 Channels

Weiming Bu, Qiansheng Liang, Lianteng Zhi, Lina Maciunas, more

Molecular Neurobiology > 2018 > 55 > 2 > 1692-1702

Inhalational general anesthetics, such as sevoflurane and isoflurane, modulate a subset of brain Kv1 potassium channels. However, the Kv1.2 channel is resistant to propofol, a commonly used intravenous alkylphenol anesthetic. We hypothesize that propofol binds to a presumed pocket involving the channel’s S4–S5 linker, but functional transduction is poor and, therefore, propofol efficacy is low. To...

article

Neurocognitive Adverse Effects of Anesthesia in Adults and Children: Gaps in Knowledge

Christopher G. Ward, Roderic G. Eckenhoff

Drug Safety > 2016 > 39 > 7 > 613-626

Numerous preclinical and clinical studies investigating the neurodevelopmental and neurocognitive effects of exposure to anesthesia and the combination of anesthesia and surgery have demonstrated histopathological and both temporary and long-term cognitive and behavioral effects at the extremes of the human age spectrum. Increasing coverage in the lay press for both our youngest and oldest patient...

article

Mechanistic Insights into the Modulation of Voltage-Gated Ion Channels by Inhalational Anesthetics

Manuel Covarrubias, Annika F. Barber, Vincenzo Carnevale, Werner Treptow, more

Biophysical Journal > 2015 > 109 > 10 > 2003-2011

General anesthesia is a relatively safe medical procedure, which for nearly 170 years has allowed life saving surgical interventions in animals and people. However, the molecular mechanism of general anesthesia continues to be a matter of importance and debate. A favored hypothesis proposes that general anesthesia results from direct multisite interactions with multiple and diverse ion channels in...

article

Taxane modulation of anesthetic sensitivity in surgery for nonmetastatic breast cancer

Regina E. Linganna, Warren J. Levy, Ivan J. Dmochowski, Roderic G. Eckenhoff, more

Journal of Clinical Anesthesia > 2015 > 27 > 6 > 481-485

The mechanism of action of commonly used general anesthetics is largely unknown. One hypothesized mechanism is through modulation of microtubule stability. Taxanes, a subset of chemotherapeutic drugs known to alter microtubule stability and commonly used to treat breast cancer, offer a natural experiment to test our hypothesis that patients exposed to taxanes prior to surgery, as compared to after...

article

A Shared Binding Site for Propofol and Thiopental in ELIC

Monica N. Kinde, Weiming Bu, Edom Seyoum, Qiang Chen, more

Biophysical Journal > 2015 > 108 > 2 Supplement 1 > 55a

article

Sites and functional consequence of VDAC–alkylphenol anesthetic interactions

Brian P. Weiser, Weiming Bu, David Wong, Roderic G. Eckenhoff

FEBS Letters > 2014 > 588 > 23 > 4398-4403

General anesthetics have previously been shown to bind mitochondrial VDAC. Here, using a photoactive analog of the anesthetic propofol, we determined that alkylphenol anesthetics bind to Gly56 and Val184 on rat VDAC1. By reconstituting rat VDAC into planar bilayers, we determined that propofol potentiates VDAC gating with asymmetry at the voltage polarities; in contrast, propofol does not affect the...

article

‘Clickable’-Photoactive Propofol Analogue for the Identification of Anesthetic Targets

Kellie A. Woll, Benika Pinch Pinch, William P. Dailey, Roderic G. Eckenhoff

Biophysical Journal > 2014 > 106 > 2 Supplement 1 > 478a

article

Mechanisms Revealed Through General Anesthetic Photolabeling

Brian P. Weiser, Kellie A. Woll, William P. Dailey, Roderic G. Eckenhoff

Current Anesthesiology Reports > 2014 > 4 > 1 > 57-66

General anesthetic photolabels are used to reveal molecular targets and molecular binding sites of anesthetic ligands. After identification, the relevance of anesthetic substrates or binding sites can be tested in biological systems. Halothane and photoactive analogs of isoflurane, propofol, etomidate, neurosteroids, anthracene, and long chain alcohols have been used in anesthetic photolabeling experiments...

article

Anesthesia, surgery, illness and Alzheimer's disease

Roderic G. Eckenhoff, Krzysztof F. Laudansky

Progress in Neuropsychopharmacology & Biological Psychiatry > 2013 > 47 > Complete > 162-166

Patients and their families have, for many decades, detected subtle changes in cognition subsequent to surgery, and only recently has this been subjected to scientific scrutiny. Through a combination of retrospective human studies, small prospective biomarker studies, and experiments in animals, it is now clear that durable consequences of both anesthesia and surgery occur, and that these intersect...

article

Using the problem-based learning discussion (PBLD) to facilitate research

Roderic G. Eckenhoff

Journal of Clinical Anesthesia > 2013 > 25 > 6 > 433

article

Identifying the Propofol Binding Site(S) in Heterologously Expressed Human Alpha1 Beta3 Gaba-A Receptors using a Photoreactive Propofol Analog

Selwyn S. Jayakar, Xiaojuan Zhou, Zuzana Dostalova, William P. Dailey, more

Biophysical Journal > 2013 > 104 > 2 Supplement 1 > 637a

article

Photoaffinity Labeling the Propofol Binding Site in GLIC

David C. Chiara, Qiang Chen, Tommy Tillman, Jonathan F. Gill, more

Biophysical Journal > 2013 > 104 > 2 Supplement 1 > 636a

article

NMR structure and dynamics of a designed water-soluble transmembrane domain of nicotinic acetylcholine receptor

Tanxing Cui, David Mowrey, Vasyl Bondarenko, Tommy Tillman, more

BBA - Biomembranes > 2012 > 1818 > 3 > 617-626

The nicotinic acetylcholine receptor (nAChR) is an important therapeutic target for a wide range of pathophysiological conditions, for which rational drug designs often require receptor structures at atomic resolution. Recent proof-of-concept studies demonstrated a water-solubilization approach to structure determination of membrane proteins by NMR (Slovic et al., PNAS, 101: 1828–1833, 2004; Ma et...

article

Anesthetic Mechanisms: Worms Light the Way

Roderic G. Eckenhoff

Current Biology > 2011 > 21 > 24 > R985-R986

In the nematode C. elegans, immobility induced by the anesthetic halothane is coupled to its ability to modulate neuronal resting membrane potential, perhaps through effects on leak channels; a similar anesthetic, isoflurane, appears to work a different way.

article

Anesthesia in presymptomatic Alzheimer’s disease: A study using the triple-transgenic mouse model

Junxia X. Tang, Feras Mardini, Breanna M. Caltagarone, Sean T. Garrity, more

Alzheimer's & Dementia: The Journal of the Alzheimer's Association > 2011 > 7 > 5 > 521-531.e1

Experimental evidence suggests that anesthetics accelerate symptomatic neurodegenerative disorders such as Alzheimer’s disease (AD). Because AD pathology precedes symptoms, we asked ourselves whether anesthetic exposure in the presymptomatic interval accelerated neuropathology and appearance of symptoms.Triple-transgenic AD mice were exposed to general aesthetics, either halothane or isoflurane, at...

article

Visualization of the General Anesthetic Site in a K+ Channel

Annika F. Barber, Qiansheng Liang, Cristiano Amaral, Roderic G. Eckenhoff, more

Biophysical Journal > 2011 > 100 > 3 Supplement 1 > 100a

article

m -Azipropofol (AziP m ) a Photoactive Analogue of the Intravenous General Anesthetic Propofol

Michael A. Hall, Jin Xi, Chong Lor, Shuiping Dai, more

Journal of Medicinal Chemistry > 2010 > 53 > 15 > 5667 - 5675

article

Effects of commonly used inhalational anesthetic isoflurane on intracellular calcium homeostasis and neuropathology in Alzheimer's disease

Huafeng Wei, Yi Peng, Ge Liang, King-Ho Cheung, more

Alzheimer's & Dementia > 2010 > 6 > 4(S) > S394

article

Azi-isoflurane, a Photolabel Analog of the Commonly Used Inhaled General Anesthetic Isoflurane

Roderic G. Eckenhoff, Jin Xi, Motomu Shimaoka, Aditya Bhattacharji, more

ACS Chemical Neuroscience > 2010 > 1 > 2 > 139 - 145

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Search results for: Roderic G. Eckenhoff

Sex effects on behavioral markers of emergence from propofol and isoflurane anesthesia in rats

Sites and Functional Consequence of Alkylphenol Anesthetic Binding to Kv1.2 Channels

Neurocognitive Adverse Effects of Anesthesia in Adults and Children: Gaps in Knowledge

Mechanistic Insights into the Modulation of Voltage-Gated Ion Channels by Inhalational Anesthetics

Taxane modulation of anesthetic sensitivity in surgery for nonmetastatic breast cancer

A Shared Binding Site for Propofol and Thiopental in ELIC

Sites and functional consequence of VDAC–alkylphenol anesthetic interactions

‘Clickable’-Photoactive Propofol Analogue for the Identification of Anesthetic Targets

Mechanisms Revealed Through General Anesthetic Photolabeling

Anesthesia, surgery, illness and Alzheimer's disease

Using the problem-based learning discussion (PBLD) to facilitate research

Identifying the Propofol Binding Site(S) in Heterologously Expressed Human Alpha1 Beta3 Gaba-A Receptors using a Photoreactive Propofol Analog

Photoaffinity Labeling the Propofol Binding Site in GLIC

NMR structure and dynamics of a designed water-soluble transmembrane domain of nicotinic acetylcholine receptor

Anesthetic Mechanisms: Worms Light the Way

Anesthesia in presymptomatic Alzheimer’s disease: A study using the triple-transgenic mouse model

Visualization of the General Anesthetic Site in a K+ Channel

m -Azipropofol (AziP m ) a Photoactive Analogue of the Intravenous General Anesthetic Propofol

Effects of commonly used inhalational anesthetic isoflurane on intracellular calcium homeostasis and neuropathology in Alzheimer's disease

Azi-isoflurane, a Photolabel Analog of the Commonly Used Inhaled General Anesthetic Isoflurane

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