Search results for: Stephanie Baud

Items from 1 to 7 out of 7 results

article

Inverse docking method for new proteins targets identification: A parallel approach

Romain Vasseur, Stéphanie Baud, Luiz Angelo Steffenel, Xavier Vigouroux, more

Parallel Computing > 2015 > 42 > Complete > 48-59

Molecular docking is a widely used computational technique that allows studying structure-based interactions complexes between biological objects at the molecular scale. The purpose of the current work is to develop a set of tools that allows performing inverse docking, i.e., to test at a large scale a chemical ligand on a large dataset of proteins, which has several applications on the field of drug...

article

Molecular-level characterization of elastin-like constructs and human aortic elastin

Andrea Heinz, Christoph U. Schräder, Stéphanie Baud, Fred W. Keeley, more

Matrix Biology > 2014 > 38 > Complete > 12-21

This study aimed to characterize the structures of two elastin-like constructs, one composed of a cross-linked elastin-like polypeptide and the other one of cross-linked tropoelastin, and native aortic elastin. The structures of the insoluble materials and human aortic elastin were investigated using scanning electron microscopy. Additionally, all samples were digested with enzymes of different specificities,...

article

Molecular mechanism of β‐sheet self‐organization at water‐hydrophobic interfaces

Ana Nikolic, Stéphanie Baud, Sarah Rauscher, Régis Pomès

Proteins: Structure, Function, and Bioinformatics > 79 > 1 > 1 - 22

The capacity to form β‐sheet structure and to self‐organize into amyloid aggregates is a property shared by many proteins. Severe neurodegenerative pathologies such as Alzheimer's disease are thought to involve the interaction of amyloidogenic protein oligomers with neuronal membranes. To understand the experimentally observed catalysis of amyloid formation by lipid membranes and other water‐hydrophobic...

article

Molecular Basis for the Catalysis of B-Sheet Formation by Water-Nonpolar Interfaces

Ana Nikolic, Stéphanie Baud, Sarah Rauscher, Régis Pomès

Biophysical Journal > 2010 > 98 > 3 Supplement 1 > 252a

article

High-level expression and purification of the human bradykinin B2 receptor in a tetracycline-inducible stable HEK293S cell line

Paméla Camponova, Stéphanie Baud, Hélène Mattras, Isabelle Duroux-Richard, more

Protein Expression and Purification > 2007 > 55 > 2 > 300-311

The B ₂ bradykinin receptor belongs to the G-protein coupled receptor family. Development of new drugs for this important therapeutic target requires structural information on the receptor. The main goal of the present work was to overexpress the human B ₂ receptor for future biophysical studies. Different tagged B ₂ receptors were engineered and their properties were evaluated...

article

Proline and Glycine Control Protein Self-Organization into Elastomeric or Amyloid Fibrils

Sarah Rauscher, Stéphanie Baud, Ming Miao, Fred W. Keeley, more

Structure > 2006 > 14 > 11 > 1667-1676

Elastin provides extensible tissues, including arteries and skin, with the propensity for elastic recoil, whereas amyloid fibrils are associated with tissue-degenerative diseases, such as Alzheimer's. Although both elastin-like and amyloid-like materials result from the self-organization of proteins into fibrils, the molecular basis of their differing physical properties is poorly understood. Using...

article

RAR Antagonists Diminish the Level of DNA Binding by the RAR/RXR Heterodimer ^†

Nicolas Poujol, Emmanuel Margeat, Stephanie Baud, Catherine A. Royer

Biochemistry > 2003 > 42 > 17 > 4918 - 4925

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Search results for: Stephanie Baud

Inverse docking method for new proteins targets identification: A parallel approach

Molecular-level characterization of elastin-like constructs and human aortic elastin

Molecular mechanism of β‐sheet self‐organization at water‐hydrophobic interfaces

Molecular Basis for the Catalysis of B-Sheet Formation by Water-Nonpolar Interfaces

High-level expression and purification of the human bradykinin B2 receptor in a tetracycline-inducible stable HEK293S cell line

Proline and Glycine Control Protein Self-Organization into Elastomeric or Amyloid Fibrils

RAR Antagonists Diminish the Level of DNA Binding by the RAR/RXR Heterodimer †

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RAR Antagonists Diminish the Level of DNA Binding by the RAR/RXR Heterodimer ^†