Search results for: A. Grant Mauk

Items from 1 to 20 out of 52 results

chapter

Electron transfer in genetically engineered proteins. The cytochrome c paradigm

A. Grant Mauk

Structure and Bonding > Long-Range Electron Transfer in Biology > 131-157

The investigation of metalloprotein electron transfer mechanisms through structural and functional characterization of modified proteins produced by site-directed mutagenesis provides a systematic means of gaining new, often quantitative, insight into the structural characteristics that regulate the electrochemical, kinetic and protein-binding properties of such proteins. This review discusses aspects...

article

Structural and kinetic properties of Rhodobacter sphaeroides photosynthetic reaction centers containing exclusively Zn-coordinated bacteriochlorophyll as bacteriochlorin cofactors

Rafael G. Saer, Jie Pan, Amelia Hardjasa, Su Lin, more

BBA - Bioenergetics > 2014 > 1837 > 3 > 366-374

The Zn-BChl-containing reaction center (RC) produced in a bchD (magnesium chelatase) mutant of Rhodobacter sphaeroides assembles with six Zn-bacteriochlorophylls (Zn-BChls) in place of four Mg-containing bacteriochlorophylls (BChls) and two bacteriopheophytins (BPhes). This protein presents unique opportunities for studying biological electron transfer, as Zn-containing chlorins can exist in 4-, 5-,...

article

Hydrogen Bond Strength Modulates the Mechanical Strength of Ferric-Thiolate Bonds in Rubredoxin

Peng Zheng, Shin-ichi J. Takayama, A Grant Mauk, Hongbin Li

Biophysical Journal > 2013 > 104 > 2 Supplement 1 > 169a

article

Photochemical reagents for the study of metalloproteins by flash photolysis

Federico I. Rosell, A. Grant Mauk

Coordination Chemistry Reviews > 2012 > 256 > 3-4 > 465

article

Photochemical reagents for the study of metalloproteins by flash photolysis

Federico I. Rosell, A. Grant Mauk

Coordination Chemistry Reviews > 2011 > 255 > 7-8 > 737-756

Flash photolysis has been used extensively in the advancement of our understanding of the electron transfer reactivity of metalloproteins and in investigation of the kinetic complexities of electron transfer-initiated protein folding. Additional opportunities for the use of flash photolysis to understand the functional properties of metalloproteins have been afforded through the use of photoactive...

article

Iron core mineralisation in prokaryotic ferritins

Nick E. Le Brun, Allister Crow, Michael E.P. Murphy, A. Grant Mauk, more

BBA - General Subjects > 2010 > 1800 > 8 > 732-744

To satisfy their requirement for iron while at the same time countering the toxicity of this highly reactive metal ion, prokaryotes have evolved proteins belonging to two distinct sub-families of the ferritin family: the bacterioferritins (BFRs) and the bacterial ferritins (Ftns). Recently, Ftn homologues have also been identified and characterised in archaeon species. All of these prokaryotic ferritins...

article

Metal Ion Facilitated Dissociation of Heme from b -Type Heme Proteins

Marcia R. Mauk, Federico I. Rosell, A. Grant Mauk

Journal of the American Chemical Society > 2009 > 131 > 46 > 16976 - 16983

article

Atypical Effects of Salts on the Stability and Iron Release Kinetics of Human Transferrin

Rajesh Kumar, A. Grant Mauk

The Journal of Physical Chemistry B > 2009 > 113 > 36 > 12400 - 12409

article

Plectosphaeroic Acids A, B, and C, Indoleamine 2,3-Dioxygenase Inhibitors Produced in Culture by a Marine Isolate of the Fungus Plectosphaerella cucumerina

Gavin Carr, Wendy Tay, Helen Bottriell, Sarah K. Andersen, more

Organic Letters > 2009 > 11 > 14 > 2996 - 2999

article

Synthesis of Indoleamine 2,3-Dioxygenase Inhibitory Analogues of the Sponge Alkaloid Exiguamine A

Gavin Carr, Marco K. W. Chung, A. Grant Mauk, Raymond J. Andersen

Journal of Medicinal Chemistry > 2008 > 51 > 9 > 2634 - 2637

article

Phospholipid membranes affect tertiary structure of the soluble cytochrome b5 heme-binding domain

Liana V. Basova, Elisaveta I. Tiktopulo, Victor P. Kutyshenko, A. Grant Mauk, more

BBA - Biomembranes > 2008 > 1778 > 4 > 1015-1026

The influence of charged phospholipid membranes on the conformational state of the water-soluble fragment of cytochrome b ₅ has been investigated by a variety of techniques at neutral pH. The results of this work provide the first evidence that aqueous solutions with high phospholipid/protein molar ratios (pH 7.2) induce the cytochrome to undergo a structural transition from the native conformation...

article

Recombinant Expression and Initial Characterization of the Putative Human Enteric Ferric Reductase Dcytb ^†

Susanne Ludwiczek, Federico I. Rosell, Martin L. Ludwiczek, A. Grant Mauk

Biochemistry > 2008 > 47 > 2 > 753 - 761

article

Chromatographically Distinguishable Heme Insertion Isoforms of Human Hemopexin ^†

Marcia R. Mauk, Federico I. Rosell, A. Grant Mauk

Biochemistry > 2007 > 46 > 51 > 15033 - 15041

article

Stable Copper−Nitrosyl Formation by Nitrite Reductase in Either Oxidation State ^†

Elitza I. Tocheva, Federico I. Rosell, A. Grant Mauk, Michael E. P. Murphy

Biochemistry > 2007 > 46 > 43 > 12366 - 12374

article

Effects of Metal Ion Binding on Structural Dynamics of Human Hemopexin ^†

Federico I. Rosell, Marcia R. Mauk, A. Grant Mauk

Biochemistry > 2007 > 46 > 32 > 9301 - 9309

article

Exiguamine A, an Indoleamine-2,3-dioxygenase (IDO) Inhibitor Isolated from the Marine Sponge Neopetrosia exigua

Harry C. Brastianos, Eduardo Vottero, Brian O. Patrick, Rob Van Soest, more

Journal of the American Chemical Society > 2006 > 128 > 50 > 16046 - 16047

article

Contribution of the heme propionate groups to the electron transfer and electrostatic properties of myoglobin

Anthony R. Lim, Bhavini P. Sishta, A. Grant Mauk

Journal of Inorganic Biochemistry > 2006 > 100 > 12 > 2017-2023

The role of the heme propionate groups in determining the electron transfer and electrostatic properties of myoglobin have been studied by thermodynamic, kinetic, and spectroscopic studies of horse heart myoglobin in which the heme propionate groups are esterified. Spectroelectrochemical analysis has established that the E _m,7 of dimethylester heme-substituted Mb (DME-Mb) (E _m,7 =100...

article

Cofacial Heme Binding is Linked to Dimerization by a Bacterial Heme Transport Protein

Anson C.K. Chan, Barbara Lelj-Garolla, Federico I. Rosell, Kira A. Pedersen, more

Journal of Molecular Biology > 2006 > 362 > 5 > 1108-1119

Campylobacter jejuni is a leading bacterial cause of food-borne illness in the developed world. Like most pathogens, C. jejuni requires iron that must be acquired from the host environment. Although the iron preference of the food-borne pathogen C. jejuni is not established, this organism possesses heme transport systems to acquire iron. ChaN is an iron-regulated lipoprotein from C. jejuni proposed...

article

Indoleamine 2,3-Dioxygenase Inhibitors from the Northeastern Pacific Marine Hydroid Garveia annulata

Alban Pereira, Eduardo Vottero, Michel Roberge, A. Grant Mauk, more

Journal of Natural Products > 2006 > 69 > 10 > 1496 - 1499

article

Cytochrome b5 is a major reductant in vivo of human indoleamine 2,3-dioxygenase expressed in yeast

Eduardo Vottero, David A. Mitchell, Michael J. Page, Ross T.A. MacGillivray, more

FEBS Letters > 2006 > 580 > 9 > 2265-2268

The evolutionary relationship of indoleamine 2,3-dioxygenase (IDO) to some gastropod myoglobins suggests that IDO may undergo autoxidation in vivo such that one or more currently unidentified electron donors are required to maintain IDO heme iron in the active, ferrous state. To evaluate this hypothesis we have used yeast knockout mutants in combination with a recently developed yeast growth assay...

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Search results for: A. Grant Mauk

Electron transfer in genetically engineered proteins. The cytochrome c paradigm

Structural and kinetic properties of Rhodobacter sphaeroides photosynthetic reaction centers containing exclusively Zn-coordinated bacteriochlorophyll as bacteriochlorin cofactors

Hydrogen Bond Strength Modulates the Mechanical Strength of Ferric-Thiolate Bonds in Rubredoxin

Photochemical reagents for the study of metalloproteins by flash photolysis

Photochemical reagents for the study of metalloproteins by flash photolysis

Iron core mineralisation in prokaryotic ferritins

Metal Ion Facilitated Dissociation of Heme from b -Type Heme Proteins

Atypical Effects of Salts on the Stability and Iron Release Kinetics of Human Transferrin

Plectosphaeroic Acids A, B, and C, Indoleamine 2,3-Dioxygenase Inhibitors Produced in Culture by a Marine Isolate of the Fungus Plectosphaerella cucumerina

Synthesis of Indoleamine 2,3-Dioxygenase Inhibitory Analogues of the Sponge Alkaloid Exiguamine A

Phospholipid membranes affect tertiary structure of the soluble cytochrome b5 heme-binding domain

Recombinant Expression and Initial Characterization of the Putative Human Enteric Ferric Reductase Dcytb ^†

Chromatographically Distinguishable Heme Insertion Isoforms of Human Hemopexin ^†

Stable Copper−Nitrosyl Formation by Nitrite Reductase in Either Oxidation State ^†

Effects of Metal Ion Binding on Structural Dynamics of Human Hemopexin ^†

Exiguamine A, an Indoleamine-2,3-dioxygenase (IDO) Inhibitor Isolated from the Marine Sponge Neopetrosia exigua

Contribution of the heme propionate groups to the electron transfer and electrostatic properties of myoglobin

Cofacial Heme Binding is Linked to Dimerization by a Bacterial Heme Transport Protein

Indoleamine 2,3-Dioxygenase Inhibitors from the Northeastern Pacific Marine Hydroid Garveia annulata

Cytochrome b5 is a major reductant in vivo of human indoleamine 2,3-dioxygenase expressed in yeast

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