Annexin 5 is a Ca 2+ -binding protein, the function of which is poorly understood. Structural and electrophysiological studies have shown that annexin 5 can mediate Ca 2+ fluxes across phospholipid membranes in vitro. There is, however, no direct evidence for the existence of annexin 5 Ca 2+ channels in living cells. Here, we show that annexin 5 inserts into phospholipid...
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