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Amyloid β peptide (Aβ) 1–42 is known to be involved in the onset of Alzheimer’s disease (AD). We developed a click peptide of Aβ1–42 as a useful tool for AD research on the basis of an O-acyl isopeptide method. The click peptide quickly produced intact Aβ1–42 via a pH-dependent O-to-N intramolecular acyl migration (pH-click). Herein, a click peptide (26-O-acyl isoAβ1–42 (E22Δ)) of a new mutant Aβ1–42...
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