Search results for: Yukihiro Isogai

Items from 1 to 14 out of 14 results

article

Parathyroid Hormone Shifts Cell Fate of a Leptin Receptor‐Marked Stromal Population from Adipogenic to Osteoblastic Lineage

Mengyu Yang, Atsushi Arai, Nobuyuki Udagawa, Lijuan Zhao, more

Journal of Bone and Mineral Research > 34 > 10 > 1952 - 1963

Intermittent parathyroid hormone (iPTH) treatment induces bone anabolic effects that result in the recovery of osteoporotic bone loss. Human PTH is usually given to osteoporotic patients because it induces osteoblastogenesis. However, the mechanism by which PTH stimulates the expansion of stromal cell populations and their maturation toward the osteoblastic cell lineage has not be elucidated. Mouse...

article

Increased cortical porosity is associated with daily, not weekly, administration of equivalent doses of teriparatide

Roger Zebaze, Ryoko Takao-Kawabata, Yu Peng, Ali Ghasem Zadeh, more

Bone > 2017 > 99 > C > 80-84

The pharmacokinetic profile of parathyroid hormone (PTH) determines its effects on bone resorption and formation. When administered intermittently, anabolic effects are favored in comparison with the continuous treatment. Among the intermittent treatment regimens, lower frequency of administration may have a lower effect on bone remodeling. We therefore hypothesized that weekly administration of teriparatide...

article

Differences in vertebral, tibial, and iliac cancellous bone metabolism in ovariectomized rats

Aya Takakura, Ryoko Takao-Kawabata, Yukihiro Isogai, Makoto Kajiwara, more

Journal of Bone and Mineral Metabolism > 2016 > 34 > 3 > 291-302

Bone histomorphometry is usually performed on the iliac bone in humans and the tibia or vertebrae in rats. Bone metabolism differences among skeletal sites may be problematic when translating experimental results from rats to humans, but data on such differences in rats are lacking. Therefore, we examined the differences in bone structure and metabolism among skeletal sites using the lumbar vertebra...

article

Comparison of treatment effects of teriparatide and the bisphosphonate risedronate in an aged, osteopenic, ovariectomized rat model under various clinical conditions

Ayano Sugie-Oya, Aya Takakura, Ryoko Takao-Kawabata, Hiroko Sano, more

Journal of Bone and Mineral Metabolism > 2016 > 34 > 3 > 303-314

Teriparatide and bisphosphonates are osteoporosis medications that increase bone mineral density (BMD) and prevent fracture, but each has a different mechanism of action. Teriparatide promotes bone formation, while bisphosphonates suppress bone resorption. In the clinical setting, however, drug selection is not always tailored to the particular clinical condition of the patient or mechanism of action...

article

Induction and antagonism of pica induced by teriparatide in rats

Kouichi Yamamoto, Naoto Kato, Yukihiro Isogai, Tatsuhiko Kuroda, more

European Journal of Pharmacology > 2015 > 764 > Complete > 457-462

Intermittent subcutaneous injection of teriparatide, an active fragment of human parathyroid hormone, is clinically used for the treatment of osteoporosis. Patients suffer from nausea, which is one of the side effects teriparatide induces; however, the etiology of teriparatide-induced nausea remains unknown. We have reported pica, kaolin ingestion behavior, can be used as an assessment of nausea-related...

article

Early Effects of Single and Low-Frequency Repeated Administration of Teriparatide, hPTH(1-34), on Bone Formation and Resorption in Ovariectomized Rats

Yukihiro Isogai, Ryoko Takao-Kawabata, Aya Takakura, Emika Sugimoto, more

Calcified Tissue International > 2015 > 97 > 4 > 412-420

Intermittent repeated administration of teriparatide (TPTD) has potent anabolic effects on bones in vivo. However, TPTD has both anabolic and catabolic effects on osteoblasts in vitro, and the mechanisms underlying its promotion of bone formation are unclear. This study aimed to elucidate the time-dependent changes in bone formation and resorption by examining changes in bone turnover markers and...

article

Three-Times-Weekly Administration of Teriparatide Improves Vertebral and Peripheral Bone Density, Microarchitecture, and Mechanical Properties Without Accelerating Bone Resorption in Ovariectomized Rats

Ryoko Takao-Kawabata, Yukihiro Isogai, Aya Takakura, Yukari Shimazu, more

Calcified Tissue International > 2015 > 97 > 2 > 156-168

Daily and weekly administration of teriparatide (PTH_1–34) reduces the risk of osteoporotic bone fractures. However, their effects on markers of bone formation and bone resorption differ. These results indicate that the dosing frequency of teriparatide may affect bone metabolism and bone structure, with different effects on bone strength. In the present study, to evaluate the dose-related effects of...

article

Novel sandwich ELISAs for rat DMP1: Age-related decrease of circulatory DMP1 levels in male rats

Sunao Sato, Jun Hashimoto, Yu Usami, Kaname Ohyama, more

Bone > 2013 > 57 > 2 > 429-436

Dentin matrix protein 1 (DMP1), a noncollagenous bone matrix protein produced by osteocytes, regulates matrix mineralization and phosphate homeostasis. The lack of a precise assay for circulating DMP1 levels impairs further investigation of the protein's biological significance. Because full-length precursor DMP1 is cleaved into NH ₂ - and COOH-terminal fragments during the secretory process,...

article

Chemo-enzymatic synthesis of eel calcitonin glycosylated at two sites with the same and different carbohydrate structures

Katsuji Haneda, Midori Takeuchi, Mizuka Tagashira, Toshiyuki Inazu, more

Carbohydrate Research > 2006 > 341 > 2 > 181-190

Naturally occurring glycopeptides and glycoproteins usually contain more than one glycosylation site, and the structure of the carbohydrate attached is often different from site to site. Therefore, synthetic methods for preparing peptides and proteins that are glycosylated at multiple sites, possibly with different carbohydrate structures, are needed. Here, we report a chemo-enzymatic approach for...

article

Chemo-enzymatic synthesis and structure-activity study of artificially N-glycosylated eel calcitonin derivatives with a complex type oligosaccharide

Katsuji Haneda, Mizuka Tagashira, Eiichi Yoshino, Midori Takeuchi, more

Glycoconjugate Journal > 2004 > 21 > 6 > 377-386

Starting from N-glycosylated eel calcitonin derivatives that contain an N-acetyl-D-glucosamine residue specifically at the 3rd, 14th, 20th or 26th amino acid residue, corresponding glycopeptides with a complex-type oligosaccharide attached to the respective amino acid residue were synthesized by means of a transglycosylation reaction catalyzed by an endo-β-N-acetylglucosaminidase from Mucor hiemalis...

article

Site-Dependent Effect of O-Glycosylation on the Conformation and Biological Activity of Calcitonin ^†

Mizuka Tagashira, Hideki Iijima, Yukihiro Isogai, Masayuki Hori, more

Biochemistry > 2001 > 40 > 37 > 11090 - 11095

article

Effect of carbohydrate structure on biological activity of artificially N-glycosylated eel calcitonin

Mizuka Tagashira, Atsushi Tanaka, Kunio Hisatani, Yukihiro Isogai, more

Glycoconjugate Journal > 2001 > 18 > 6 > 449-455

To reveal the function of the carbohydrate portion of glycopeptides and glycoproteins, we chemo-enzymatically synthesized artificially N-glycosylated derivatives of eel calcitonin and studied their three-dimensional structure and biological activity. The CD and NMR spectra in trifluoroethanol-H₂O solution showed that the glycosylation did not change the three-dimensional structure. All the derivatives...

article

Matrix-assisted laser desorption ionization mass spectrometry for the analysis of monosulfated oligosaccharides

Yuqin Dai, Randy M. Whittal, Craig A. Bridges, Yukihiro Isogai, more

Carbohydrate Research > 1997 > 304 > 1 > 1-9

Sulfated oligosaccharides are an important class of compounds in the field of glycobiology. Mass spectrometric analysis of these molecules is challenging due to their readiness to dissociate in sample preparation and their tendency to fragment during ionization. Moreover, their presence in small quantity in biological systems poses additional problems. We report the development of a mass spectrometric...

article

The α(1,3)Fucosyltransferase Fuc-TVII Controls Leukocyte Trafficking through an Essential Role in L-, E-, and P-selectin Ligand Biosynthesis

Petr Malý, Aron D. Thall, Bronislawa Petryniak, Clare E. Rogers, more

Cell > 1996 > 86 > 4 > 643-653

α(1,3)Fucosylated oligosaccharides represent components of leukocyte counterreceptors for E- and P-selectins and of L-selectin ligands expressed by lymph node high endothelial venules (HEV). The identity of the α(1,3)fucosyltransferase(s) required for their expression has been uncertain, as has a requirement for α(1,3)fucosylation in HEV L-selectin ligand activity. We demonstrate here that mice deficient...

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