Search results for: Sandro Sonnino

Items from 1 to 20 out of 99 results

article

Regulation of signal transduction by gangliosides in lipid rafts: focus on GM3–IR and GM1–TrkA interactions

Giulia Lunghi, Maria Fazzari, Maria Grazia Ciampa, Laura Mauri, more

The interactions between gangliosides and proteins belonging to the same or different lipid domains and their influence on physiological and pathological states have been analysed in detail. A well‐known factor impacting on lipid–protein interactions and their biological outcomes is the dynamic composition of plasma membrane. This review focuses on GM1 and GM3 gangliosides because they are an integral...

article

Human SND2 mediates ER targeting of GPI‐anchored proteins with low hydrophobic GPI attachment signals

Jing Yang, Tetsuya Hirata, Yi‐Shi Liu, Xin‐Yu Guo, more

FEBS Letters > 595 > 11 > 1542 - 1558

Over 100 glycosylphosphatidylinositol‐anchored proteins (GPI‐APs) are encoded in the mammalian genome. It is not well understood how these proteins are targeted and translocated to the endoplasmic reticulum (ER). Here, we reveal that many GPI‐APs, such as CD59, CD55, and CD109, utilize human SND2 (hSND2)‐dependent ER targeting machinery. We also found that signal recognition particle receptors seem...

article

The international Glycoconjugate organization awards

Sandro Sonnino

Glycoconjugate Journal > 2019 > 36 > 4 > 237-237

article

GM1 promotes TrkA‐mediated neuroblastoma cell differentiation by occupying a plasma membrane domain different from TrkA

Elena Chiricozzi, Erika Di Biase, Margherita Maggioni, Giulia Lunghi, more

Journal of Neurochemistry > 149 > 2 > 231 - 241

Recently, we highlighted that the ganglioside GM1 promotes neuroblastoma cells differentiation by activating the TrkA receptor through the formation of a TrkA–GM1 oligosaccharide complex at the cell surface. To study the TrkA–GM1 interaction, we synthesized two radioactive GM1 derivatives presenting a photoactivable nitrophenylazide group at the end of lipid moiety, 1 or at position 6 of external...

article

The Neuroprotective Role of the GM1 Oligosaccharide, II³Neu5Ac-Gg₄, in Neuroblastoma Cells

Elena Chiricozzi, Margherita Maggioni, Erika Biase, Giulia Lunghi, more

Molecular Neurobiology > 2019 > 56 > 10 > 6673-6702

Recently, we demonstrated that the GM1 oligosaccharide, II³Neu5Ac-Gg₄ (OligoGM1), administered to cultured murine Neuro2a neuroblastoma cells interacts with the NGF receptor TrkA, leading to the activation of the ERK1/2 downstream pathway and to cell differentiation. To understand how the activation of the TrkA pathway is able to trigger key biochemical signaling, we performed a proteomic analysis...

article

Sphingolipids and neuronal degeneration in lysosomal storage disorders

Sara Grassi, Elena Chiricozzi, Laura Mauri, Sandro Sonnino, more

Journal of Neurochemistry > 148 > 5 > 600 - 611

Ceramide, sphingomyelin, and glycosphingolipids (both neutral and acidic) are characterized by the presence in the lipid moiety of an aliphatic base known as sphingosine. Altogether, they are called sphingolipids and are particularly abundant in neuronal plasma membranes, where, via interactions with the other membrane lipids and membrane proteins, they play a specific role in modulating the cell...

article

Human Remyelination Promoting Antibody Stimulates Astrocytes Proliferation Through Modulation of the Sphingolipid Rheostat in Primary Rat Mixed Glial Cultures

Sara Grassi, Paola Giussani, Simona Prioni, Donald Button, more

Neurochemical Research > 2019 > 44 > 6 > 1460-1474

Remyelination promoting human IgMs effectively increase the number of myelinated axons in animal models of multiple sclerosis. Hence, they ultimately stimulate myelin production by oligodendrocytes (OLs); however, their exact mechanism of action remains to be elucidated, and in particular, it remains unclear whether they are directly targeting OLs, or their action is mediated by effects on other cell...

article

New horizons in Glycobiology research

Sandro Sonnino

FEBS Letters > 592 > 23 > 3771 - 3772

article

Introduction: the Glycobiology of nervous system

Sandro Sonnino, Alessandro Prinetti

Glycoconjugate Journal > 2018 > 35 > 4 > 343-344

article

Neuronal membrane dynamics as fine regulator of sphingolipid composition

Massimo Aureli, Maura Samarani, Nicoletta Loberto, Elena Chiricozzi, more

Glycoconjugate Journal > 2018 > 35 > 4 > 397-402

Sphingolipid metabolism is an intricate network of several interdependent and co-regulated pathways. In addition to the mainstream biosynthetic and catabolic pathways, several processes, even if less important in contributing to the final tissue sphingolipid composition from the quantitative point of view, might become relevant when sphingolipid metabolism is for any reason dysregulated and concur...

article

Assignment by Negative-Ion Electrospray Tandem Mass Spectrometry of the Tetrasaccharide Backbones of Monosialylated Glycans Released from Bovine Brain Gangliosides

Wengang Chai, Yibing Zhang, Laura Mauri, Maria G. Ciampa, more

Journal of The American Society for Mass Spectrometry > 2018 > 29 > 6 > 1308-1318

Gangliosides, as plasma membrane-associated sialylated glycolipids, are antigenic structures and they serve as ligands for adhesion proteins of pathogens, for toxins of bacteria, and for endogenous proteins of the host. The detectability by carbohydrate-binding proteins of glycan antigens and ligands on glycolipids can be influenced by the differing lipid moieties. To investigate glycan sequences...

article

On the use of cholera toxin

Elena Chiricozzi, Laura Mauri, Maria Grazia Ciampa, Alessandro Prinetti, more

Glycoconjugate Journal > 2018 > 35 > 2 > 161-163

article

Cross‐talk between sphingosine‐1‐phosphate and EGFR signaling pathways enhances human glioblastoma cell invasiveness

Maria Grazia Cattaneo, Claudia Vanetti, Maura Samarani, Massimo Aureli, more

FEBS Letters > 592 > 6 > 949 - 961

We show that glioblastoma multiform (GBM) cells overexpressing the constitutively active form of the epidermal growth factor receptor [epidermal growth factor receptor variant III (EGFRvIII) and U87MG human GBM cell line overexpressing EGFRvIII (EGFR+) cells] possess greater invasive properties and have higher levels of extracellular sphingosine‐1‐phosphate (S1P) and increased sphingosine kinase‐1...

article

Editorial

Sandro Sonnino

Glycoconjugate Journal > 2018 > 35 > 1 > 1-1

article

Role of the GM1 ganglioside oligosaccharide portion in the TrkA‐dependent neurite sprouting in neuroblastoma cells

Elena Chiricozzi, Diego Yuri Pomè, Margherita Maggioni, Erika Di Biase, more

Journal of Neurochemistry > 143 > 6 > 645 - 659

GM1 ganglioside (II³NeuAc‐Gg₄Cer) is known to promote neurite formation in neuroblastoma cells by activating TrkA‐MAPK pathway. The molecular mechanism by which GM1 is involved in the neurodifferentiation process is still unknown, however, in vitro and in vivo evidences have suggested that the oligosaccharide portion of this ganglioside could be involved. Here, we report that, similarly to the entire...

article

Unravelling the role of sphingolipids in cystic fibrosis lung disease

Massimo Aureli, Domitilla Schiumarini, Nicoletta Loberto, Rosaria Bassi, more

Chemistry and Physics of Lipids > 2016 > 200 > C > 94-103

Cystic fibrosis (CF), one of the most common lethal hereditary diseases of white European populations, is caused by loss-of-function mutations in the CF Transmembrane conductance Regulator (CFTR) gene. One of the main causes of mortality is the onset of CF lung disease, which is characterized by chronic infection and inflammation resulting in the progressive remodelling, irreversible damage and fibrosis...

article

The role of sphingolipids in neuronal plasticity of the brain

Sandro Sonnino, Alessandro Prinetti

Journal of Neurochemistry > 137 > 4 > 485 - 488

This Editorial highlights a study by Müller et al. in which the authors suggest a new sphingolipid‐dependent mechanism for behavioral extinction. Their study should be considered in the broad perspective of sphingolipid metabolic pathways and traffic (depicted in the graphic).Read the highlighted article ‘A sphingolipid mechanism for behavioral extinction’ on page .

article

Preferential interaction of the Alzheimer peptide Aβ‐(1–42) with Omega‐3‐containing lipid bilayers: structure and interaction studies

Alessandro Emendato, Roberta Spadaccini, Augusta De Santis, Remo Guerrini, more

FEBS Letters > 590 > 4 > 582 - 591

Many age‐related neurodegenerative diseases, including Alzheimer Disease (AD), are elicited by an interplay of genetic, environmental, and dietary factors. Food rich in Omega‐3 phospholipids seems to reduce the AD incidence. To investigate the molecular basis of this beneficial effect, we have investigated by CD and ESR studies the interaction between the Alzheimer peptide Aβ‐(1–42) and biomimetic...

article

Serum Antibodies to Glycans in Peripheral Neuropathies

Sandro Sonnino, Elena Chiricozzi, Maria Grazia Ciampa, Laura Mauri, more

Molecular Neurobiology > 2017 > 54 > 2 > 1564-1567

In peripheral neuropathies, such as sensorimotor neuropathies, motor neuron diseases, or the Guillain-Barré syndrome, serum antibodies recognizing saccharide units, portion of oligosaccharides, or oligosaccharide chains, have been found. These antibodies are called anti-glycosphingolipid (GSL) or anti-ganglioside antibodies. However, the information on the aglycone carrying the hydrophilic oligosaccharide...

chapter

Role of Gangliosides and Plasma Membrane-Associated Sialidase in the Process of Cell Membrane Organization

Sandro Sonnino, Vanna Chigorno, Massimo Aureli, Anie Priscilla Masilamani, more

Advances in Experimental Medicine and Biology > The Molecular Immunology of Complex Carbohydrates-3 > Structures and Functions of Glycolipids > 297-316

Glycosphingolipids are amphiphilic membrane lipids characterized by the presence of a long-chain (C18 or C20) amino alcohol, which has the trivial name “sphingosine.” Glycosphingolipids are components of all eukaryotic cell membranes, and gangliosides (glycosphingolipids containing sialic acid residues in their oligosaccharide chains) are particularly abundant in the plasma membranes of neurons. As...

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INFONA - science communication portal

Search results for: Sandro Sonnino

Regulation of signal transduction by gangliosides in lipid rafts: focus on GM3–IR and GM1–TrkA interactions

Human SND2 mediates ER targeting of GPI‐anchored proteins with low hydrophobic GPI attachment signals

The international Glycoconjugate organization awards

GM1 promotes TrkA‐mediated neuroblastoma cell differentiation by occupying a plasma membrane domain different from TrkA

The Neuroprotective Role of the GM1 Oligosaccharide, II³Neu5Ac-Gg₄, in Neuroblastoma Cells

Sphingolipids and neuronal degeneration in lysosomal storage disorders

Human Remyelination Promoting Antibody Stimulates Astrocytes Proliferation Through Modulation of the Sphingolipid Rheostat in Primary Rat Mixed Glial Cultures

New horizons in Glycobiology research

Introduction: the Glycobiology of nervous system

Neuronal membrane dynamics as fine regulator of sphingolipid composition

Assignment by Negative-Ion Electrospray Tandem Mass Spectrometry of the Tetrasaccharide Backbones of Monosialylated Glycans Released from Bovine Brain Gangliosides

On the use of cholera toxin

Cross‐talk between sphingosine‐1‐phosphate and EGFR signaling pathways enhances human glioblastoma cell invasiveness

Editorial

Role of the GM1 ganglioside oligosaccharide portion in the TrkA‐dependent neurite sprouting in neuroblastoma cells

Unravelling the role of sphingolipids in cystic fibrosis lung disease

The role of sphingolipids in neuronal plasticity of the brain

Preferential interaction of the Alzheimer peptide Aβ‐(1–42) with Omega‐3‐containing lipid bilayers: structure and interaction studies

Serum Antibodies to Glycans in Peripheral Neuropathies

Role of Gangliosides and Plasma Membrane-Associated Sialidase in the Process of Cell Membrane Organization

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