Search results for: Alastair J. Barr

Items from 1 to 7 out of 7 results

article

Crystal Structures of ABL-Related Gene (ABL2) in Complex with Imatinib, Tozasertib (VX-680), and a Type I Inhibitor of the Triazole Carbothioamide Class

Eidarus Salah, Emilie Ugochukwu, Alastair J. Barr, Frank von Delft, more

Journal of Medicinal Chemistry > 2011 > 54 > 7 > 2359 - 2367

article

Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome

Alastair J. Barr, Emilie Ugochukwu, Wen Hwa Lee, Oliver N.F. King, more

Cell > 2009 > 136 > 2 > 352-363

Protein tyrosine phosphatases (PTPs) play a critical role in regulating cellular functions by selectively dephosphorylating their substrates. Here we present 22 human PTP crystal structures that, together with prior structural knowledge, enable a comprehensive analysis of the classical PTP family. Despite their largely conserved fold, surface properties of PTPs are strikingly diverse. A potential...

article

Sequence-specific ¹H, ¹³C and ¹⁵N backbone resonance assignments of the 34 kDa catalytic domain of human PTPN7

Mark Jeeves, Darren M. McClelland, Alastair J. Barr, Michael Overduin

Biomolecular NMR Assignments > 2008 > 2 > 2 > 101-103

PTPN7 is a protein tyrosine phosphatase responsible for inactivation of MAPK in leukocytes. Here we report the backbone resonance assignments of the 34 kDa phosphatase domain of human PTPN7, which is amplified in myeloid malignancies and deleted in lymphoproliferative disorders.

article

MAPK-specific tyrosine phosphatases: new targets for drug discovery?

Alastair J. Barr, Stefan Knapp

Trends in Pharmacological Sciences > 2006 > 27 > 10 > 525-530

Protein tyrosine phosphatases (PTPs) have key roles in a diverse range of cellular processes, and their dysregulation is associated with several human diseases. Many PTPs are recognized as potential drug targets; however, inhibitor development has focused only on a small number of enzymes, most notably PTP1B for type II diabetes and obesity, and MKP1 and CDC25 for cancer. The future challenge of selective-inhibitor...

article

Phospholipase C-β2 interacts with mitogen-activated protein kinase kinase 3

Alastair J. Barr, Robin Marjoram, Jing Xu, Ralph Snyderman

Biochemical and Biophysical Research Communications > 2002 > 293 > 1 > 647-652

Phospholipase C (PLC)-β enzymes (isoenzymes β1-β4) are activated by G protein subunits, leading to the generation of intracellular messengers which mobilize calcium and activate protein kinase C. It has recently been recognized that these enzymes interact with and are regulated by proteins other than G proteins. Using the yeast two-hybrid technique to screen a leukocyte library we identified mitogen-activated...

article

RGS4 Inhibits Platelet-Activating Factor Receptor Phosphorylation and Cellular Responses ^†

Ricardo M. Richardson, Robin J. Marjoram, Alastair J. Barr, Ralph Snyderman

Biochemistry > 2001 > 40 > 12 > 3583 - 3588

article

Function and regulation of chemoattractant receptors

Bodduluri Haribabu, Ricardo M. Richardson, Margrith W. Verghese, Alastair J. Barr, more

Immunologic Research > 2000 > 22 > 2-3 > 271-279

Phagocyte migration and activation at sites of inflammation is mediated through chemoattractant receptors that are coupled to G-proteins. Early studies from our laboratory demonstrated G-protein-mediated phospholipase C activation by chemoattractants. Recently, this laboratory developed cellular and animal models to allow biochemical, cell biological and molecular genetic approaches to be used in...

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Search results for: Alastair J. Barr

Crystal Structures of ABL-Related Gene (ABL2) in Complex with Imatinib, Tozasertib (VX-680), and a Type I Inhibitor of the Triazole Carbothioamide Class

Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome

Sequence-specific 1H, 13C and 15N backbone resonance assignments of the 34 kDa catalytic domain of human PTPN7

MAPK-specific tyrosine phosphatases: new targets for drug discovery?

Phospholipase C-β2 interacts with mitogen-activated protein kinase kinase 3

RGS4 Inhibits Platelet-Activating Factor Receptor Phosphorylation and Cellular Responses †

Function and regulation of chemoattractant receptors

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Sequence-specific ¹H, ¹³C and ¹⁵N backbone resonance assignments of the 34 kDa catalytic domain of human PTPN7

RGS4 Inhibits Platelet-Activating Factor Receptor Phosphorylation and Cellular Responses ^†