Search results for: Derek J. Quinn

Items from 1 to 7 out of 7 results

article

Ene Reductase Enzymes for the Aromatisation of Tetralones and Cyclohexenones to Naphthols and Phenols

Paul P. Kelly, David Lipscomb, Derek J. Quinn, Ken Lemon, more

Advanced Synthesis & Catalysis > 358 > 5 > 731 - 736

Ene reductases (EREDs) have great potential as oxidation biocatalysts, as demonstrated by their efficient conversion of a number of tetralones to the corresponding naphthols. Of 96 enzymes tested, 57 were able to produce 2‐naphthol in this way. Further tests with substituted tetralones revealed typically high conversions up to >99%. The reactions were performed under mild conditions in aqueous...

article

Gene delivery using dimethyldidodecylammonium bromide-coated PLGA nanoparticles

François Fay, Derek J. Quinn, Brendan F. Gilmore, Paul A. McCarron, more

Biomaterials > 2010 > 31 > 14 > 4214-4222

In this present work we describe a poly(lactic-co-glycolic acid) (PLGA) nanoparticle formulation for intracellular delivery of plasmid DNA. This formulation was developed to encapsulate DNA within PLGA nanoparticles that combined salting out and emulsion–evaporation processes. This process reduced the requirement for sonication which can induce degradation of the DNA. A monodispersed nanoparticle...

article

Expedited Solid-Phase Synthesis of Fluorescently Labeled and Biotinylated Aminoalkane Diphenyl Phosphonate Affinity Probes for Chymotrypsin- and Elastase-Like Serine Proteases

Brendan F. Gilmore, Derek J. Quinn, Thomas Duff, George R. Cathcart, more

Bioconjugate Chemistry > 2009 > 20 > 11 > 2098 - 2105

article

Antibody Targeting of Camptothecin-Loaded PLGA Nanoparticles to Tumor Cells

Paul A. McCarron, Waleed M. Marouf, Derek J. Quinn, Francois Fay, more

Bioconjugate Chemistry > 2008 > 19 > 8 > 1561 - 1569

article

Activity-based selection of a proteolytic species using ribosome display

Derek J. Quinn, Stephen Cunningham, Brian Walker, Christopher J. Scott

Biochemical and Biophysical Research Communications > 2008 > 370 > 1 > 77-81

We have examined the potential of displaying a protease species in vitro using ribosome display and demonstrate specific capture on the basis of its catalytic activity. Using a model bacterial cysteine protease, sortase A (SrtA), we show that this enzyme can be functionally expressed in vitro. By overlap PCR we constructed ribosome display templates with the SrtA open reading frame fused to a C terminal...

article

Immunocolloidal Targeting of the Endocytotic Siglec-7 Receptor Using Peripheral Attachment of Siglec-7 Antibodies to Poly(Lactide-co-Glycolide) Nanoparticles

Christopher J. Scott, Waleed M. Marouf, Derek J. Quinn, Richard J. Buick, more

Pharmaceutical Research > 2008 > 25 > 1 > 135-146

Purpose To prepare a nanoparticulate formulation expressing variable peripheral carboxyl density using non-endcapped and endcapped poly(lactide-co-glycolide), conjugated to antibodies recognising the siglec-7 receptor, which is expressed on most acute myeloid leukaemias. The aim is to exploit this receptor as a therapeutic target by constructing an internalising drug-loaded nanoparticle able to translocate...

article

mt4216C variant in linkage with the mtDNA TJ cluster may confer a susceptibility to mitochondrial dysfunction resulting in an increased risk of Parkinson's disease in the Irish

Owen A. Ross, Rose McCormack, Lynn D. Maxwell, R. Alistair Duguid, more

Experimental Gerontology > 2003 > 38 > 4 > 397-405

Polymorphism of the mtDNA genome has been implicated as playing a role in the development and pathogenesis of Parkinson's disease (PD). A PCR-RFLP methodology was employed to generate genetic haplotypes for a cohort of 90 PD sufferers. No association was observed between the various mtDNA haplotypes observed and PD in comparison to healthy aged controls. The longevity-associated European J haplogroup...

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Search results for: Derek J. Quinn

Ene Reductase Enzymes for the Aromatisation of Tetralones and Cyclohexenones to Naphthols and Phenols

Gene delivery using dimethyldidodecylammonium bromide-coated PLGA nanoparticles

Expedited Solid-Phase Synthesis of Fluorescently Labeled and Biotinylated Aminoalkane Diphenyl Phosphonate Affinity Probes for Chymotrypsin- and Elastase-Like Serine Proteases

Antibody Targeting of Camptothecin-Loaded PLGA Nanoparticles to Tumor Cells

Activity-based selection of a proteolytic species using ribosome display

Immunocolloidal Targeting of the Endocytotic Siglec-7 Receptor Using Peripheral Attachment of Siglec-7 Antibodies to Poly(Lactide-co-Glycolide) Nanoparticles

mt4216C variant in linkage with the mtDNA TJ cluster may confer a susceptibility to mitochondrial dysfunction resulting in an increased risk of Parkinson's disease in the Irish

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