Search results for: Kevin D. Moeller

Items from 1 to 20 out of 73 results

article

A Building Block Approach for the Total Synthesis of YM‐385781

Yu Zhu, Siyue Liu, Johnny Zigmond, Kevin M. Kaltenbronn, more

European Journal of Organic Chemistry > 26 > 20 > n/a - n/a

YM‐254890 and FR900359 are potent and selective inhibitors of the Gq/11‐signaling pathway. As such, they have been attractive targets for both synthesis and biological studies. Yet in spite of this effort, a versatile synthetic approach to the molecules that allows for the rapid construction of a variety of non‐natural and labelled analogs and an increase in the amount of those analogs available remains...

article

Lessons from an Array: Using an Electrode Surface to Control the Selectivity of a Solution‐Phase Chemical Reaction

Enqi Feng, Qiwei Jing, Kevin D. Moeller

Angewandte Chemie International Edition > 61 > 10 > n/a - n/a

Electrochemistry offers a variety of novel means by which selectivity can be introduced into synthetic organic transformations. In the work reported, it is shown how methods used to confine chemical reactions to specific sites on a microelectrode array can also be used to confine a preparative reaction to the surface of an electrode inserted into a bulk reaction solution. In so doing, the surface...

article

Lessons from an Array: Using an Electrode Surface to Control the Selectivity of a Solution‐Phase Chemical Reaction

Enqi Feng, Qiwei Jing, Kevin D. Moeller

Angewandte Chemie > 134 > 10 > n/a - n/a

article

Organic Electrochemistry: Expanding the Scope of Paired Reactions

Tiandi Wu, Kevin D. Moeller

Angewandte Chemie International Edition > 60 > 23 > 12883 - 12890

Paired electrochemical reactions allow the optimization of both atom and energy economy of oxidation and reduction reactions. While many paired electrochemical reactions take advantage of perfectly matched reactions at the anode and cathode, this matching of substrates is not necessary. In constant current electrolysis, the potential at both electrodes adjusts to the substrates in solution. In principle,...

article

Organic Electrochemistry: Expanding the Scope of Paired Reactions

Tiandi Wu, Kevin D. Moeller

Angewandte Chemie > 133 > 23 > 12993 - 13000

article

Anodic Cyclizations, Seven‐Membered Rings, and the Choice of Radical Cation vs. Radical Pathways

Robert J. Perkins, Ruozhu Feng, Qingquan Lu, Kevin D. Moeller

Chinese Journal of Chemistry > 37 > 7 > 672 - 678

While many steps in an oxidative cyclization reaction can be important, it is the cyclization step itself that plays the central role. If this step does not proceed well, then optimization of the rest of the sequence is futile. We report here that the key to the cyclization is channeling the reaction down the correct pathway. Some reactions require the use of a radical pathway and some require the...

article

Paired Electrochemical Reactions and the On‐Site Generation of a Chemical Reagent

Tiandi Wu, Bichlien H. Nguyen, Michael C. Daugherty, Kevin D. Moeller

Angewandte Chemie International Edition > 58 > 11 > 3562 - 3565

While the majority of reported paired electrochemical reactions involve carefully matched cathodic and anodic reactions, the precise matching of half reactions in an electrolysis cell is not generally necessary. During a constant current electrolysis almost any oxidation and reduction reaction can be paired, and in the presented work we capitalize on this observation by examining the coupling of anodic...

article

Paired Electrochemical Reactions and the On‐Site Generation of a Chemical Reagent

Tiandi Wu, Bichlien H. Nguyen, Michael C. Daugherty, Kevin D. Moeller

Angewandte Chemie > 131 > 11 > 3600 - 3603

article

C‐Glycosides, Array‐based Addressable Libraries, and the Versatility of Constant Current Electrochemistry

Jake A. Smith, Guoxi Xu, Ruozhu Feng, James W. Janetka, more

Electroanalysis > 28 > 11 > 2808 - 2817

Constant current electrochemical reactions are very versatile tools for conducting oxidation and reduction reactions. In the reactions, the potential at the working electrode automatically adjusts to that of the substrate in solution, a situation that allows for the same overall synthetic approach to be used for both the direct oxidation and reduction of substrates and the generation of a wide range...

chapter

Intramolecular carbon-carbon bond forming reactions at the anode

Kevin D. Moeller

Topics in Current Chemistry > Electrochemistry VI Electroorganic Synthesis: Bond Formation at Anode and Cathode > 49-86

Oxidative cyclization reactions offer a unique opportunity both for generating new carbon-carbon bonds and for gaining insight into the mechanisms that govern a variety of radical, radical cation, and cation intermediates. This review surveys recent developments in the use of electrochemistry as a tool for initiating these intriguing reactions. The transformations examined range from fragmentation...

chapter

New Approaches to the Synthesis of Addressable Microarray Molecular Libraries

Karl Maurer, Kevin D. Moeller

Integrated Analytical Systems > Microarrays > Applications > 227-246

Approaches for the synthesis of molecular libraries on addressable arrays of microelectrodes are presented. In each case, substrates are fixed to a polymer coating of the array in the regions proximal to the microelectrodes. Selected micro-electrodes are then used to synthesize chemical reagents that initiate reactions involving the substrates. The reagents generated at the electrodes are confined...

article

Practical Electrochemical Anodic Oxidation of Polycyclic Lactams for Late Stage Functionalization

Kevin J. Frankowski, Ruzhang Liu, Gregory L. Milligan, Kevin D. Moeller, more

Angewandte Chemie International Edition > 54 > 36 > 10555 - 10558

Electrochemistry provides a powerful tool for the late‐stage functionalization of complex lactams. A two‐stage protocol for converting lactams, many of which can be prepared through the intramolecular Schmidt reaction of keto azides, is presented. In the first step, anodic oxidation in MeOH using a repurposed power source provides a convenient route to lactams bearing a methoxy group adjacent to nitrogen...

article

Practical Electrochemical Anodic Oxidation of Polycyclic Lactams for Late Stage Functionalization

Kevin J. Frankowski, Ruzhang Liu, Gregory L. Milligan, Kevin D. Moeller, more

Angewandte Chemie > 127 > 36 > 10701 - 10704

article

Competition studies and the relative reactivity of enol ether and allylsilane coupling partners toward ketene dithioacetal derived radical cations

John M. Campbell, Jake A. Smith, Luisalberto Gonzalez, Kevin D. Moeller

Tetrahedron Letters > 2015 > 56 > 23 > 3595-3599

The relative reactivity of enol ether and allylsilane trapping groups toward a ketene dithioacetal derived radical cation has been examined with the use of competition and cyclic voltammetry studies. The competition studies pit the olefinic trapping groups against an alcohol trapping group under conditions of both kinetic and thermodynamic control. With the enol ether trapping group, the chemoselectivity...

article

Oxidative Cyclization Reactions: Controlling the Course of a Radical Cation‐Derived Reaction with the Use of a Second Nucleophile

Alison Redden, Robert J. Perkins, Kevin D. Moeller

Angewandte Chemie > 125 > 49 > 13103 - 13106

Der Aufbau neuer Ringsysteme: Oxidative Cyclisierungen (siehe Bild; RVC=netzartiger Glaskohlenstoff) mit zwei separaten intramolekularen Nukleophilen wurden durchgeführt, um ein von einem Enoletherabgeleitetes intermediäres Radikalkation abzufangen. Die Reaktionen bieten einen Weg zum schnellen Abfang des intermediären Radialkations, der konkurrierende Zersetzungsreaktionen vermeidet.

article

Oxidative Cyclization Reactions: Controlling the Course of a Radical Cation‐Derived Reaction with the Use of a Second Nucleophile

Alison Redden, Robert J. Perkins, Kevin D. Moeller

Angewandte Chemie International Edition > 52 > 49 > 12865 - 12868

Construction of new ring systems: Oxidative cyclizations (see picture; RVC=reticulated vitreous carbon) have been conducted that use two separate intramolecular nucleophiles to trap an enol ether‐derived radical cation intermediate. The reactions provide a means for rapidly trapping the radical cation intermediate in a manner that avoids competitive decomposition reactions.

article

Site-Selective, Cleavable Linkers: Quality Control and the Characterization of Small Molecules on Microelectrode Arrays

Bo Bi, Richard Y.-C. Huang, Karl Maurer, Ceng Chen, more

The Journal of Organic Chemistry > 2011 > 76 > 21 > 9053 - 9059

article

Site-Selectively Functionalizing Microelectrode Arrays: The Use of Cu(I)-Catalysts

Jennifer Bartels, Peng Lu, Karl Maurer, Amy V. Walker, more

Langmuir > 2011 > 27 > 17 > 11199 - 11205

article

Anodic Coupling Reactions: Exploring the Generality of Curtin−Hammett Controlled Reactions

Alison Redden, Kevin D. Moeller

Organic Letters > 2011 > 13 > 7 > 1678 - 1681

article

Building Addressable Libraries: The Use of “Safety-Catch” Linkers on Microelectrode Arrays

Bo Bi, Karl Maurer, Kevin D. Moeller

Journal of the American Chemical Society > 2010 > 132 > 49 > 17405 - 17407

Publication date

Last 3 years (3)

Close

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

From:

To:
Set your own date range

Data set

ACS (34)
Elsevier (22)
Wiley (15)
Springer (2)

Journal

Journal of the American Chemical Society (16)
Organic Letters (15)
Tetrahedron (8)
Tetrahedron Letters (8)
Angewandte Chemie (6)
Angewandte Chemie International Edition (6)
Bioorganic & Medicinal Chemistry Letters (3)
Bioconjugate Chemistry (1)
Bioorganic & Medicinal Chemistry (1)
Chinese Journal of Chemistry (1)
Electroanalysis (1)
Electrochemistry Communications (1)
Electrochimica Acta (1)
European Journal of Organic Chemistry (1)
Langmuir (1)
The Journal of Organic Chemistry (1)
more

INFONA - science communication portal

Search results for: Kevin D. Moeller

A Building Block Approach for the Total Synthesis of YM‐385781

Lessons from an Array: Using an Electrode Surface to Control the Selectivity of a Solution‐Phase Chemical Reaction

Lessons from an Array: Using an Electrode Surface to Control the Selectivity of a Solution‐Phase Chemical Reaction

Organic Electrochemistry: Expanding the Scope of Paired Reactions

Organic Electrochemistry: Expanding the Scope of Paired Reactions

Anodic Cyclizations, Seven‐Membered Rings, and the Choice of Radical Cation vs. Radical Pathways

Paired Electrochemical Reactions and the On‐Site Generation of a Chemical Reagent

Paired Electrochemical Reactions and the On‐Site Generation of a Chemical Reagent

C‐Glycosides, Array‐based Addressable Libraries, and the Versatility of Constant Current Electrochemistry

Intramolecular carbon-carbon bond forming reactions at the anode

New Approaches to the Synthesis of Addressable Microarray Molecular Libraries

Practical Electrochemical Anodic Oxidation of Polycyclic Lactams for Late Stage Functionalization

Practical Electrochemical Anodic Oxidation of Polycyclic Lactams for Late Stage Functionalization

Competition studies and the relative reactivity of enol ether and allylsilane coupling partners toward ketene dithioacetal derived radical cations

Oxidative Cyclization Reactions: Controlling the Course of a Radical Cation‐Derived Reaction with the Use of a Second Nucleophile

Oxidative Cyclization Reactions: Controlling the Course of a Radical Cation‐Derived Reaction with the Use of a Second Nucleophile

Site-Selective, Cleavable Linkers: Quality Control and the Characterization of Small Molecules on Microelectrode Arrays

Site-Selectively Functionalizing Microelectrode Arrays: The Use of Cu(I)-Catalysts

Anodic Coupling Reactions: Exploring the Generality of Curtin−Hammett Controlled Reactions

Building Addressable Libraries: The Use of “Safety-Catch” Linkers on Microelectrode Arrays

Filter options

Publication date

Content availability

Publication type

Keywords

Data set

Journal

INFONA - science communication portal

Search results for: Kevin D. Moeller

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Content availability

Publication type

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options