Search results for: Ralf Bergmann

Items from 1 to 20 out of 85 results

article

Cover Feature: Versatile Bispidine‐Based Bifunctional Chelators for ⁶⁴Cu^II‐Labelling of Biomolecules (Chem. Eur. J. 9/2020)

Garima Singh, Kristof Zarschler, Sebastian Hunoldt, Irma Ivette Santana Martínez, more

Chemistry – A European Journal > 26 > 9 > 1890 - 1890

Bifunctional chelators for targeted nuclear imaging have been developed on the basis of bispidines. Reductive alkylation at the relatively inert C9‐position of bispidols paves the way for generating a number of derivatives ready to be coupled to a variety of targeting vector molecules. As these bispidine derivatives form highly stable complexes with the positron emitter ⁶⁴Cu^II, they are virtually...

article

Versatile Bispidine‐Based Bifunctional Chelators for ⁶⁴Cu^II‐Labelling of Biomolecules

Garima Singh, Kristof Zarschler, Sebastian Hunoldt, Irma Ivette Santana Martínez, more

Chemistry – A European Journal > 26 > 9 > 1989 - 2001

Bifunctional chelators as parts of modular metal‐based radiopharmaceuticals are responsible for stable complexation of the radiometal ion and for covalent linkage between the complex and the targeting vector. To avoid loss of complex stability, the bioconjugation strategy should not interfere with the radiometal chelation by occupying coordinating groups. The C9 position of the very stable Cu^II chelator...

article

Conventional CARs versus modular CARs

Anja Feldmann, Claudia Arndt, Stefanie Koristka, Nicole Berndt, more

Cancer Immunology, Immunotherapy > 2019 > 68 > 10 > 1713-1719

The clinical application of immune effector cells genetically modified to express chimeric antigen receptors (CARs) has shown impressive results including complete remissions of certain malignant hematological diseases. However, their application can also cause severe side effects such as cytokine release syndrome (CRS) or tumor lysis syndrome (TLS). One limitation of currently applied CAR T cells...

article

Anti-CAR-engineered T cells for epitope-based elimination of autologous CAR T cells

Stefanie Koristka, Pauline Ziller-Walter, Ralf Bergmann, Claudia Arndt, more

Cancer Immunology, Immunotherapy > 2019 > 68 > 9 > 1401-1415

Although CAR T-cell therapy has demonstrated tremendous clinical efficacy especially in hematological malignancies, severe treatment-associated toxicities still compromise the widespread application of this innovative technology. Therefore, developing novel approaches to abrogate CAR T-cell-mediated side effects is of great relevance. Several promising strategies pursue the selective antibody-based...

article

Theranostic CAR T cell targeting: A brief review

Claudia Arndt, Michael Bachmann, Ralf Bergmann, Nicole Berndt, more

Journal of Labelled Compounds and Radiopharmaceuticals > 62 > 8 > 533 - 540

More than hundred years ago, Paul Ehrlich postulated that our immune system should be able to recognize tumor cells. Just recently, the development of check point inhibitors, bispecific antibodies, and T cells genetically modified to express chimeric antigen receptors (CARs) underlines the true power of our immune system. T cells genetically modified with CARs can lead to complete remission of malignant...

article

Radiochemical and radiopharmacological characterization of a ⁶⁴Cu‐labeled α‐MSH analog conjugated with different chelators

Feng Gao, Wiebke Sihver, Ralf Bergmann, Martin Walther, more

Journal of Labelled Compounds and Radiopharmaceuticals > 62 > 8 > 495 - 509

Radiolabeled α‐melanocyte‐stimulating hormone (α‐MSH) derivatives have a high potential for diagnosis and treatment of melanoma, because of high specificity and binding affinity to the melanocortin‐1 receptor (MC1R). Hence, the α‐MSH‐derived peptide NAP‐NS1 with a β‐Ala linker (ε‐Ahx‐β‐Ala‐Nle‐Asp‐His‐D‐Phe‐Arg‐Trp‐Gly‐NH₂) was conjugated to different chelators: either to NOTA (p‐SCN‐Bn‐1,4,7‐triazacyclononane‐1,4,7‐triacetic...

article

Synthesis, ¹⁸F-labelling and radiopharmacological characterisation of the C-terminal 30mer of Clostridium perfringens enterotoxin as a potential claudin-targeting peptide

Reik Löser, Miriam Bader, Manuela Kuchar, Robert Wodtke, more

Amino Acids > 2019 > 51 > 2 > 219-244

The cell surface receptor claudin-4 (Cld-4) is upregulated in various tumours and represents an important emerging target for both diagnosis and treatment of solid tumours of epithelial origin. The C-terminal fragment of the Clostridium perfringens enterotoxin cCPE_290–319 appears as a suitable ligand for targeting Cld-4. The synthesis of this 30mer peptide was attempted via several approaches, which...

article

Exploring pitfalls of ⁶⁴Cu-labeled EGFR-targeting peptide GE11 as a potential PET tracer

Franziska Striese, Wiebke Sihver, Feng Gao, Ralf Bergmann, more

Amino Acids > 2018 > 50 > 10 > 1415-1431

The epidermal growth factor receptor (EGFR) represents an important molecular target for both radiotracer-based diagnostic imaging and radionuclide therapy of various cancer entities. For the delivery of radionuclides to the tumor, peptides hold great potential as a transport vehicle. With respect to EGFR, the peptide YHWYGYTPQNVI (GE11) has been reported to bind the receptor with high specificity...

article

Evaluation of Brain Nuclear Medicine Imaging Tracers in a Murine Model of Sepsis-Associated Encephalopathy

Dávid Szöllősi, Nikolett Hegedűs, Dániel S. Veres, Ildikó Futó, more

Molecular Imaging and Biology > 2018 > 20 > 6 > 952-962

Purpose The purpose of this study was to evaluate a set of widely used nuclear medicine imaging agents as possible methods to study the early effects of systemic inflammation on the living brain in a mouse model of sepsis-associated encephalopathy (SAE). The lipopolysaccharide (LPS)-induced murine systemic inflammation model was selected as a model of SAE. Procedures C57BL/6 mice were used. A multimodal...

article

An orthotopic xenograft model for high-risk non-muscle invasive bladder cancer in mice: influence of mouse strain, tumor cell count, dwell time and bladder pretreatment

Doreen Huebner, Christiane Rieger, Ralf Bergmann, Martin Ullrich, more

BMC Cancer > 2017 > 17 > 1 > 1-12

Background Novel theranostic options for high-risk non-muscle invasive bladder cancer are urgently needed. This requires a thorough evaluation of experimental approaches in animal models best possibly reflecting human disease before entering clinical studies. Although several bladder cancer xenograft models were used in the literature, the establishment of an orthotopic bladder cancer model in mice...

article

Biological characterization of novel nitroimidazole‐peptide conjugates in vitro and in vivo

Ralf Bergmann, Katrin Splith, Jens Pietzsch, Michael Bachmann, more

Journal of Peptide Science > 23 > 7-8 > 597 - 609

Recently, we reported on the design of a multimodal peptide conjugate useful as delivery platform for targeting hypoxic cells. A nitroimidazole (2‐(2‐nitroimidazol‐1‐yl)acetic acid, NIA) moiety, which is selectively entrapped in hypoxic cells, was coupled to a cell‐penetrating peptide serving as the transporter. Furthermore, attachment of a bifunctional linker allowed the introduction of a diagnostic...

article

Impact of pre- and early per-treatment FDG-PET based dose-escalation on local tumour control in fractionated irradiated FaDu xenograft tumours

Christina Jentsch, Ralf Bergmann, Kerstin Brüchner, Birgit Mosch, more

Radiotherapy and Oncology > 2016 > 121 > 3 > 447-452

To investigate local tumour control after dose-escalation based on [¹⁸F]2-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET) obtained before and early during fractionated irradiation.85 mice bearing FaDu xenografts underwent FDG-PET twice: first immediately prior to the first 2-Gy fraction of irradiation (PET1_0) and second after 18°Gy (PET2_18). After these 9 fractions, animals were...

chapter

Lateral Shearing Interferometer based on a Spatial Light Modulator in the Fourier Plane

Claas Falldorf, Reiner Klattenhoff, Achim Gesierich, Christoph V. Kopylow, more

Fringe 2009 > Topic 1 > 1-6

Shearing interferometry is based on the coherent superposition of two mutually shifted representations of the same wave field, where the term shear refers to the lateral shift. The resulting interference pattern can be recorded by a camera sensor for further evaluation [1]. Since both of the interfering wave fields travel almost along the same path, shearing interferometry makes low demands regarding...

article

Radiomics-based differentiation of lung disease models generated by polluted air based on X-ray computed tomography data

Krisztián Szigeti, Tibor Szabó, Csaba Korom, Ilona Czibak, more

BMC Medical Imaging > 2016 > 16 > 1 > 1-10

Background Lung diseases (resulting from air pollution) require a widely accessible method for risk estimation and early diagnosis to ensure proper and responsive treatment. Radiomics-based fractal dimension analysis of X-ray computed tomography attenuation patterns in chest voxels of mice exposed to different air polluting agents was performed to model early stages of disease and establish differential...

article

Radiopharmacological characterization of ⁶⁴Cu-labeled α-MSH analogs for potential use in imaging of malignant melanoma

Feng Gao, Wiebke Sihver, Christoph Jurischka, Ralf Bergmann, more

Amino Acids > 2016 > 48 > 3 > 833-847

The melanocortin-1 receptor (MC1R) plays an important role in melanoma growth, angiogenesis and metastasis, and is overexpressed in melanoma cells. α-Melanocyte stimulating hormone (α-MSH) and derivatives are known to bind with high affinity at this receptor that provides the potential for selective targeting of melanoma. In this study, one linear α-MSH-derived peptide Nle-Asp-His-D-Phe-Arg-Trp-Gly-NH...

article

¹⁷⁷Lu-labelled macrocyclic bisphosphonates for targeting bone metastasis in cancer treatment

Ralf Bergmann, Marian Meckel, Vojtěch Kubíček, Jens Pietzsch, more

EJNMMI Research > 2016 > 6 > 1 > 1-12

Background Metastatic bone lesion is a common syndrome of many cancer diseases in an advanced state. The major symptom is severe pain, spinal cord compression, and pathological fracture, associated with an obvious morbidity. Common treatments including systemic application of bisphosphonate drugs aim on pain reduction and on improving the quality of life of the patient. Particularly, patients with...

article

Reduced pulmonary blood flow in regions of injury 2 hours after acid aspiration in rats

Torsten Richter, Ralf Bergmann, Guido Musch, Jens Pietzsch, more

BMC Anesthesiology > 2015 > 15 > 1 > 1-9

Background Aspiration-induced lung injury can decrease gas exchange and increase mortality. Acute lung injury following acid aspiration is characterized by elevated pulmonary blood flow (PBF) in damaged lung areas in the early inflammation stage. Knowledge of PBF patterns after acid aspiration is important for targeting intravenous treatments. We examined PBF in an experimental model at a later...

article

Comparison study of in vivo dose response to laser-driven versus conventional electron beam

Melanie Oppelt, Michael Baumann, Ralf Bergmann, Elke Beyreuther, more

Radiation and Environmental Biophysics > 2015 > 54 > 2 > 155-166

The long-term goal to integrate laser-based particle accelerators into radiotherapy clinics not only requires technological development of high-intensity lasers and new techniques for beam detection and dose delivery, but also characterization of the biological consequences of this new particle beam quality, i.e. ultra-short, ultra-intense pulses. In the present work, we describe successful in vivo...

article

Radiofluorination and first radiopharmacological characterization of a SWLAY peptide‐based ligand targeting EphA2

Marc Pretze, Birgit Mosch, Ralf Bergmann, Jörg Steinbach, more

Journal of Labelled Compounds and Radiopharmaceuticals > 57 > 11 > 660 - 665

Peptides labeled with short‐lived positron emitters are of considerable interest as probes for molecular imaging by positron emission tomography. Herein, the regioselective and convenient radiofluorination of a biologically relevant alkyne‐modified SWLAY peptide bound on solid support with the radiolabeling building block 1‐(3‐azidopropyl)‐4‐(3‐fluoropropyl)piperazine ([¹⁸F]AFP) is described. Peptides...

article

Assessment of the best N3− donors in preparation of [M(N)(PNP)]-based (M=99mTc-; 188Re) target-specific radiopharmaceuticals: Comparison among succinic dihydrazide (SDH), N-methyl-S-methyl dithiocarbazate (HDTCZ) and PEGylated N-methyl-S-methyl dithiocarbazate (HO2C-PEG600-DTCZ)

Davide Carta, Christian Jentschel, Stefan Thieme, Nicola Salvarese, more

Nuclear Medicine and Biology > 2014 > 41 > 7 > 570-581

Succinic dihydrazide (SDH), N-methyl-S-methyl dithiocarbazate (HDTCZ) and PEGylated N-methyl-S-methyl dithiocarbazate (HO₂C-PEG₆₀₀-DTCZ) are nitrido nitrogen atom donors employed for the preparation of nitride [M(N)]‐complexes (M=^99mTc and ¹⁸⁸Re).This study aims to compare the capability and the efficiency of these three N³⁻ group donors, in the preparation of [M(N)PNP]-based target-specific compounds...

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Journal of Inorganic Biochemistry (3)
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INFONA - science communication portal

Search results for: Ralf Bergmann

Cover Feature: Versatile Bispidine‐Based Bifunctional Chelators for ⁶⁴Cu^II‐Labelling of Biomolecules (Chem. Eur. J. 9/2020)

Versatile Bispidine‐Based Bifunctional Chelators for ⁶⁴Cu^II‐Labelling of Biomolecules

Conventional CARs versus modular CARs

Anti-CAR-engineered T cells for epitope-based elimination of autologous CAR T cells

Theranostic CAR T cell targeting: A brief review

Radiochemical and radiopharmacological characterization of a ⁶⁴Cu‐labeled α‐MSH analog conjugated with different chelators

Synthesis, ¹⁸F-labelling and radiopharmacological characterisation of the C-terminal 30mer of Clostridium perfringens enterotoxin as a potential claudin-targeting peptide

Exploring pitfalls of ⁶⁴Cu-labeled EGFR-targeting peptide GE11 as a potential PET tracer

Evaluation of Brain Nuclear Medicine Imaging Tracers in a Murine Model of Sepsis-Associated Encephalopathy

An orthotopic xenograft model for high-risk non-muscle invasive bladder cancer in mice: influence of mouse strain, tumor cell count, dwell time and bladder pretreatment

Biological characterization of novel nitroimidazole‐peptide conjugates in vitro and in vivo

Impact of pre- and early per-treatment FDG-PET based dose-escalation on local tumour control in fractionated irradiated FaDu xenograft tumours

Lateral Shearing Interferometer based on a Spatial Light Modulator in the Fourier Plane

Radiomics-based differentiation of lung disease models generated by polluted air based on X-ray computed tomography data

Radiopharmacological characterization of ⁶⁴Cu-labeled α-MSH analogs for potential use in imaging of malignant melanoma

¹⁷⁷Lu-labelled macrocyclic bisphosphonates for targeting bone metastasis in cancer treatment

Reduced pulmonary blood flow in regions of injury 2 hours after acid aspiration in rats

Comparison study of in vivo dose response to laser-driven versus conventional electron beam

Radiofluorination and first radiopharmacological characterization of a SWLAY peptide‐based ligand targeting EphA2

Assessment of the best N3− donors in preparation of [M(N)(PNP)]-based (M=99mTc-; 188Re) target-specific radiopharmaceuticals: Comparison among succinic dihydrazide (SDH), N-methyl-S-methyl dithiocarbazate (HDTCZ) and PEGylated N-methyl-S-methyl dithiocarbazate (HO2C-PEG600-DTCZ)

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