Search results for: Federico Boschi

Items from 1 to 20 out of 36 results

article

A New Method to Easily Assess Bacteriostatic and Bactericidal Activity of Ultraviolet Radiation Using Quantitative Image Analysis

Angela Sandri, Maria M. Lleò, Pietro Bontempi, Federico Boschi

Photochemistry and Photobiology > 99 > 6 > 1476 - 1482

Ultraviolet (UV) radiation can elicit both bactericidal and bacteriostatic activity depending on light parameters and targeted bacteria. Current methods based on bacterial growth on solid medium allow measurement of only bactericidal but not bacteriostatic activity, while liquid cultures exhibit low light penetration. Here, we propose a method to quantify both bactericidal and bacteriostatic activity...

article

How to estimate the sarcomere size based on oblique sections of skeletal muscle

Federico Boschi

Journal of Anatomy > 243 > 4 > 648 - 657

Ultrastructural analysis of muscular biopsy is based on images of longitudinal sections of the fibers. Sometimes, due to experimental limitations, the resulting sections are instead oblique, and no accurate morphological information can be extracted with standard analysis methods. Thus, the biopsy is performed again, but this is too invasive and time‐consuming. In this study, we focused our attention...

article

Unpleasant olfactory and gustatory stimuli increase pain unpleasantness in patients with chronic oral burning pain: An exploratory study

Angela Sandri, Maria Paola Cecchini, Alice Zanini, Riccardo Nocini, more

European Journal of Pain > 26 > 5 > 1094 - 1106

Background Despite mounting evidence for the powerful influence of smell and taste substances in experimental pain, our knowledge of their effects in the clinical context is scarce, especially for patients with chronic oral burning pain. To fill this gap, we investigated the effect of olfactory and gustatory stimuli on pain perception in patients with chronic oral burning pain, a disabling condition...

article

Photon emission and changes in fluorescent properties of bone after laser irradiation

Angela Sandri, Petra R. Basso, Ilaria Corridori, Marina Protasoni, more

Journal of Biophotonics > 14 > 6 > n/a - n/a

Laser scalpels used in medical surgery concentrate light energy, heating the tissues. Recently, we reported thermoluminescence emission from laser‐treated soft tissues. Here we investigated the thermo‐optical effects caused by a laser operating at 808 nm on animal bones (beef ribs) through luminescence and fluorescence imaging, thermal imaging and scanning electron microscopy. Laser‐induced artificial...

article

Small animal irradiator dose distribution verification using radioluminescence imaging

Antonello E. Spinelli, Emilano D'Agostino, Sara Broggi, Fiorino Claudio, more

Journal of Biophotonics > 13 > 7 > n/a - n/a

The main objective of this work was the development of a novel 2D dosimetry approach for small animal external radiotherapy using radioluminescence imaging (RLI) with a commercial complementary metal oxide semiconductor detector. Measurements of RLI were performed on the small animal image‐guided platform SmART, RLI data were corrected for perspective distortion using Matlab. Four irradiation fields...

article

Weak biophoton emission after laser surgery application in soft tissues: Analysis of the optical features

Federico Boschi, Petra R. Basso, Ilaria Corridori, Giovanni Durando, more

Journal of Biophotonics > 12 > 9 > n/a - n/a

Nowadays, laser scalpels are commonly used in surgery, replacing the traditional surgical scalpels for several applications involving cutting or ablating living biological tissue. Laser scalpels are generally used to concentrate light energy in a very small‐sized area; light energy is then converted in heat by the tissues. In other cases, the fiber glass tip of the laser scalpel is heated to high...

article

T‐cell tracking using Cerenkov and radioluminescence imaging

Federico Boschi, Francesco De Sanctis, Stefano Ugel, Antonello E. Spinelli

Journal of Biophotonics > 11 > 10 > n/a - n/a

Cancer immunotherapy is a promising strategy based on the ability of the immune system to kill selected cells. In the development of an effective T‐cell therapy, the noninvasive cell tracking methods play a crucial role. Here, we investigate the potentialities of T‐cell marked with radionuclides in order to detect their localization with imaging techniques in small animal rodents. A protocol to label...

article

Mild ozonisation activates antioxidant cell response by the Keap1/Nrf2 dependent pathway

Mirco Galiè, Manuela Costanzo, Alice Nodari, Federico Boschi, more

Free Radical Biology and Medicine > 2018 > 124 > C > 114-121

Treatment with low-dose ozone is successfully exploited as an adjuvant therapy in the treatment of several disorders. Although the list of medical applications of ozone therapy is increasing, molecular mechanisms underlying its beneficial effects are still partially known. Clinical and experimental evidence suggests that the therapeutic effects of ozone treatment may rely on its capability to mount...

article

Optical emission of ²²³Radium: in vitro and in vivo preclinical applications

Federico Boschi, Francesco De Sanctis, Antonello E. Spinelli

Journal of Biophotonics > 11 > 4 > n/a - n/a

²²³Radium (²²³Ra) is widely used in nuclear medicine to treat patients with osseous metastatic prostate cancer. In clinical practice ²²³Ra cannot be imaged directly; however, gamma photons produced by its short‐lived daughter nuclides can be captured by conventional gamma cameras. In this work, we show that ²²³Ra and its short‐lived daughter nuclides can be detected with optical imaging techniques...

article

Innovative approach to safely induce controlled lipolysis by superparamagnetic iron oxide nanoparticles-mediated hyperthermic treatment

Maria Rosaria Marinozzi, Laura Pandolfi, Manuela Malatesta, Miriam Colombo, more

The International Journal of Biochemistry & Cell Biology > 2017 > 93 > C > 62-73

During last years, evidence has been provided on the involvement of overweight and obesity in the pathogenesis and aggravation of several life-threatening diseases. Here, we demonstrate that, under appropriate administration conditions, polyhedral iron oxide nanoparticles are efficiently and safely taken up by 3T3 cell line-derived adipocytes (3T3 adipocytes) in vitro. Since these nanoparticles proved...

article

Radioluminescence from Tc-99m in glass predicts local dose

Nicole L. Ackerman, Federico Boschi, Antonello E. Spinelli

Physica Medica > 2017 > 42 > C > 112-115

The widely-used gamma-emitter Tc-99m has been shown to lead to optical emissions in mice and glass. We investigated the possibility that these emissions are due to the Cerenkov effect and whether the light emitted is proportional to local dose. By using a Geant4 Monte Carlo model matched to an experimental measurement, we show that the light detected by a small animal optical imaging system provides...

article

Nanoformulations for dimethyl fumarate: Physicochemical characterization and in vitro/in vivo behavior

Elisabetta Esposito, Rita Cortesi, Markus Drechsler, Jie Fan, more

European Journal of Pharmaceutics and Biopharmaceutics > 2017 > 115 > C > 285-296

Dimethyl fumarate has been demonstrated useful in relapsing remitting multiple sclerosis treatment (Tecfidera®). Nevertheless, since Tecfidera® capsules induce flushing, gastro-intestinal events and other more serious drawbacks, in this investigation a nanoparticle based system to be administered by an alternative way is proposed. In particular this study describes the preparation and characterization...

article

Quantum dots labelling allows detection of the homing of mesenchymal stem cells administered as immunomodulatory therapy in an experimental model of pancreatic islets transplantation

Silvia Mannucci, Laura Calderan, Paola Quaranta, Sara Antonini, more

Journal of Anatomy > 230 > 3 > 381 - 388

Cell transplantation is considered a promising therapeutic approach in several pathologies but still needs innovative and non‐invasive imaging technologies to be validated. The use of mesenchymal stem cells (MSCs) attracts major interest in clinical transplantation thanks to their regenerative properties, low immunogenicity and ability to regulate immune responses. In several animal models, MSCs are...

article

Effect of physical exercise and anabolic steroid treatment on spinal motoneurons and surrounding glia of wild-type and ALS mice

Roman M. Kassa, Roberta Bonafede, Federico Boschi, Marina Bentivoglio, more

Brain Research > 2017 > 1657 > C > 269-278

Motoneuron degeneration is the hallmark of amyotrophic lateral sclerosis (ALS). The cause and predisposing factors for sporadic ALS are still unknown. Exposure to a specific environmental risk factors in subjects with a susceptibility genotype may increase the risk of the disease. The role of physical activity and the use of anabolic steroids are still debated in epidemiological studies on patients...

article

Simulating the dynamics of lipid droplets in adipocyte differentiation

Federico Boschi, Vanni Rizzatti, Mauro Zamboni, Andrea Sbarbati

Computer Methods and Programs in Biomedicine > 2017 > 138 > C > 65-71

Lipid droplets are cellular organelles that regulate the storage and hydrolysis of neutral lipids. The dynamic of lipid droplets (LDs), during the differentiation process from fibroblast-like cells into adipocyte, is strictly related to the lipid storage in cells. The number and size of the LDs depends on the lipidic or lipolytic stimulations to which the cells are exposed.Here, we propose a computational...

article

Bremsstrahlung radiation detection for small animal imaging using a CCD detector

Antonello E. Spinelli, Federico Boschi

Physica Medica > 2016 > 32 > 5 > 706-708

The use of optical methods for the detection of radionuclides is becoming an established tool for preclinical molecular imaging experiments. In this paper we present a set of proof of principle experiments showing that planar bremsstrahlung radiation images can be detected with an intensifying screen using a small animal optical imager based on charge coupled device detector.We develop a bremsstrahlung...

article

In vivo monitoring of lung inflammation in CFTR-deficient mice

Fabio Stellari, Gabriella Bergamini, Francesca Ruscitti, Angela Sandri, more

Journal of Translational Medicine > 2016 > 14 > 1 > 1-9

Background Experimentally, lung inflammation in laboratory animals is usually detected by the presence of inflammatory markers, such as immune cells and cytokines, in the bronchoalveolar lavage fluid (BALF) of sacrificed animals. This method, although extensively used, is time, money and animal life consuming, especially when applied to genetically modified animals. Thus a new and more convenient...

article

Exosome derived from murine adipose-derived stromal cells: Neuroprotective effect on in vitro model of amyotrophic lateral sclerosis

Roberta Bonafede, Ilaria Scambi, Daniele Peroni, Valentina Potrich, more

Experimental Cell Research > 2016 > 340 > 1 > 150-158

Therapeutic strategies for the fatal neurodegenerative disease amyotrophic lateral sclerosis (ALS) have not yet provided satisfactory results. Interest in stem cells for the treatment of neurodegenerative diseases is increasing and their beneficial action seems to be due to a paracrine effect via the release of exosomes, main mediators of cell–cell communication. Here we wished to assess, in vitro,...

chapter

In vivo and in vitro imaging using a multimodal optical system

Carmen R. Gigliotti, Luisa Altabella, Federico Boschi, Massimo Crippa, more

2015 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) > 1 - 3

2015 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)

Bioluminescence in vitro studies are usually performed with dedicated microscopes. In this work, we proposed a novel image recovery algorithm and a multimodal system prototype to perform bioluminescence microscopy. A super resolution regularization algorithm (SRRA) was developed and applied in a feasibility study using Geant4 Monte Carlo (MC) simulation. The method was also tested using in vitro cells...

article

Models of lipid droplets growth and fission in adipocyte cells

Federico Boschi, Vanni Rizzatti, Mauro Zamboni, Andrea Sbarbati

Experimental Cell Research > 2015 > 336 > 2 > 253-262

Lipid droplets (LD) are spherical cellular inclusion devoted to lipids storage. It is well known that excessive accumulation of lipids leads to several human worldwide diseases like obesity, type 2 diabetes, hepatic steatosis and atherosclerosis. LDs' size range from fraction to one hundred of micrometers in adipocytes and is related to the lipid content, but their growth is still a puzzling question...

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INFONA - science communication portal

Search results for: Federico Boschi

A New Method to Easily Assess Bacteriostatic and Bactericidal Activity of Ultraviolet Radiation Using Quantitative Image Analysis

How to estimate the sarcomere size based on oblique sections of skeletal muscle

Unpleasant olfactory and gustatory stimuli increase pain unpleasantness in patients with chronic oral burning pain: An exploratory study

Photon emission and changes in fluorescent properties of bone after laser irradiation

Small animal irradiator dose distribution verification using radioluminescence imaging

Weak biophoton emission after laser surgery application in soft tissues: Analysis of the optical features

T‐cell tracking using Cerenkov and radioluminescence imaging

Mild ozonisation activates antioxidant cell response by the Keap1/Nrf2 dependent pathway

Optical emission of ²²³Radium: in vitro and in vivo preclinical applications

Innovative approach to safely induce controlled lipolysis by superparamagnetic iron oxide nanoparticles-mediated hyperthermic treatment

Radioluminescence from Tc-99m in glass predicts local dose

Nanoformulations for dimethyl fumarate: Physicochemical characterization and in vitro/in vivo behavior

Quantum dots labelling allows detection of the homing of mesenchymal stem cells administered as immunomodulatory therapy in an experimental model of pancreatic islets transplantation

Effect of physical exercise and anabolic steroid treatment on spinal motoneurons and surrounding glia of wild-type and ALS mice

Simulating the dynamics of lipid droplets in adipocyte differentiation

Bremsstrahlung radiation detection for small animal imaging using a CCD detector

In vivo monitoring of lung inflammation in CFTR-deficient mice

Exosome derived from murine adipose-derived stromal cells: Neuroprotective effect on in vitro model of amyotrophic lateral sclerosis

In vivo and in vitro imaging using a multimodal optical system

Models of lipid droplets growth and fission in adipocyte cells

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