Search results for: Jun-Ping Cheng

Items from 1 to 16 out of 16 results

article

LW-AFC, a new formula derived from Liuwei Dihuang decoction, ameliorates behavioral and pathological deterioration via modulating the neuroendocrine-immune system in PrP-hAβPPswe/PS1^ΔE9 transgenic mice

Jian-Hui Wang, Xi Lei, Xiao-Rui Cheng, Xiao-Rui Zhang, more

Alzheimer's Research & Therapy > 2016 > 8 > 1 > 1-15

Background Accumulating evidence implicates the neuroendocrine immunomodulation (NIM) network in the physiopathological mechanism of Alzheimer’s disease (AD). Notably, we previously revealed that the NIM network is dysregulated in the PrP-hAβPPswe/PS1^ΔE9 (APP/PS1) transgenic mouse model of AD. Methods After treatment with a novel Liuwei Dihuang formula (LW-AFC), mice were cognitively evaluated in...

article

Design and synthesis of 5-cyclopropyl substituted cyclic acylguanidine compounds as BACE1 inhibitors

Jia-Kuo Liu, Wei Gu, Xiao-Rui Cheng, Jun-Ping Cheng, more

Chinese Chemical Letters > 2016 > 27 > 10 > 1626-1629

By taking compound 1 as a lead, a series of 5-cyclopropyl substituted cyclic acylguanidine compounds were designed and synthesized as BACE1 inhibitors, compound 4d exhibited 84-fold improved inhibition efficiency than lead compound 1. The diphenyl fragment at the P3 position and the substituents at the second phenyl ring were essential for the compounds to achieve improved inhibition efficiency. This...

article

Design and synthesis of 3′-(prop-2-yn-1-yloxy)-biphenyl substituted cyclic acylguanidine compounds as BACE1 inhibitors

Jia-Kuo Liu, Wei Gu, Xiao-Rui Cheng, Jun-Ping Cheng, more

Chinese Chemical Letters > 2016 > 27 > 6 > 961-963

Based on the lead compounds 1 and 2, a series of novel BACE1 inhibitors were designed and synthesized, among which compound 9h exhibited a 60 fold improvement in potency over the lead compound 1. This represents a good lead for the discovery of more promising BACE1 inhibitors for the potential treatment of AD. The result also showed that the prop-2-yn-1-yloxy is a suitable fragment for modification...

article

Design and synthesis of cyclic acylguanidines as BACE1 inhibitors

Jia-Kuo Liu, Wei Gu, Xiao-Rui Cheng, Jun-Ping Cheng, more

Chinese Chemical Letters > 2015 > 26 > 10 > 1327-1330

Based on the lead compound 1 reported in literature, a series of novel BACE1 inhibitors were designed and synthesized, among which compound 11 exhibited a 14-fold improvement in potency over the lead compound 1. This represents a good lead for the discovery of more promising BACE1 inhibitors for the potential treatment of AD.

article

Effect of acupuncture combined with Chinese medicine on the expression of interstitial cells of Cajal, substance P and nerve nitric oxide synthase in diabetic mice with gastroparesis antrum

Huan YU, Jun-ping CHENG, Ding-qi ZHANG, Cui-juan TANG, more

World Journal of Acupuncture - Moxibustion > 2015 > 25 > 3 > 35-42

To explore the effect of acupuncture combined with Chinese medicine on expression of interstitial cells of Cajal (ICC), substance P (SP) and nerve nitric oxide synthase (nNOS) in diabetic gastroparesis mice. Eighty Kunming male mice were randomly divided into normal group (group A, 15 mice), diabetic gastroparesis model mice group (group B, 12 mice), acupuncture combined with Chinese medicine group...

article

Lycium barbarum polysaccharide LBPF4-OL may be a new Toll-like receptor 4/MD2-MAPK signaling pathway activator and inducer

Xiao-rui Zhang, Chun-hui Qi, Jun-ping Cheng, Gang Liu, more

International Immunopharmacology > 2014 > 19 > 1 > 132-141

Recognition of the utility of the traditional Chinese medicine Lycium barbarum L. has been gradually increasing in Europe and the Americas. Many immunoregulation and antitumor effects of L. barbarum polysaccharides (LBP) have been reported, but its molecular mechanism is not yet clear. In this study, we reported that the activity of the polysaccharide LBPF4-OL, which was purified from LBP, is closely...

article

The injury progression of T lymphocytes in a mouse model with subcutaneous injection of a high dose of sulfur mustard

Yi-Zhou Mei, Xiao-Rui Zhang, Ning Jiang, Jun-Ping Cheng, more

Military Medical Research > 2014 > 1 > 1 > 1-11

Background In clinical studies, the findings on sulfur mustard (SM) toxicity for CD3⁺CD4⁺ and CD3⁺CD8⁺ T lymphocyte subsets are contradictory. In animal experiments, the effect of SM on the T cell number and proliferation is incompatible and is even the opposite of the results in human studies. In this study, we observed the dynamic changes of T lymphocytes in the first week in a high-dose SM-induced...

chapter

Synchronous buck converter modeling by a particle swarm optimization approach

Shan-Cheng Pan, Wei-Der Chang, Jun-Ping Cheng

2013 International Symposium on Next-Generation Electronics > 240 - 243

2013 International Symposium on Next-Generation Electronics (ISNE)

This paper focuses on system modeling for a physical electronic device, named synchronous buck converter, with a simple first-order mathematical model. The modeling algorithm is based on using the particle swarm optimization (PSO) which is an optimal algorithm with evolutions. In this study, three kinds of cost functions include the integral of absolute error (IAE), integral of square error (ISE),...

chapter

Parameter Identification of Nonlinear Systems Using a Particle Swarm Optimization Approach

Wei-Der Chang, Jun-Ping Cheng, Ming-Chieh Hsu, Liang-Chan Tsai

2012 Third International Conference on Networking and Computing > 113 - 117

2012 Third International Conference on Networking and Computing (ICNC)

This paper applies a particle swarm optimization (PSO) approach to the parameter identification for a class of nonlinear systems. In the PSO optimization process, the unknown system parameters are arranged in the form of a parameter vector (i.e. a particle), and the PSO algorithm employs the velocity updating and position updating formulas to an initial population, which is constituted by a great...

article

The green tea polyphenol (2)-epigallocatechin-3-gallate (EGCG) is not a β-secretase inhibitor

Xiao-Rui Cheng, Jin-Wu Zhou, Yu zhou, Jun-Ping Cheng, more

Bioorganic & Medicinal Chemistry Letters > 2012 > 22 > 3 > 1408-1414

(2)-Epigallocatechin-3-gallate (EGCG) is a major polyphenolic component of green tea. A number of studies have demonstrated EGCG has the possibility for delaying the onset or retarding the progression of Alzheimer’s disease (AD) and indicated EGCG possess inhibition of β-secretase activity. We utilized homogeneous time-resolved fluorescence assay with a substrate Eu-CEVNLDAEFK-Qsy7 to screen β-secretase...

article

Inhibitory effect of linomide on lipopolysaccharide-induced proinflammatory cytokine tumor necrosis factor-alpha production in RAW264.7 macrophages through suppression of NF-κB, p38, and JNK activation

Zhi-Yong Xiao, Wen-Xia Zhou, Yong-Xiang Zhang, Jun-Ping Cheng, more

Immunology Letters > 2007 > 114 > 2 > 81-85

Linomide is an immunomodulator that can effectively inhibit the development of several autoimmune diseases in animal models. Previously, linomide was shown to influence macrophage function, although the mechanism was elusive. In this study, we investigated the effect of linomide on the macrophage inflammatory cytokine, tumor necrosis factor-alpha (TNF-α), production induced by lipopolysaccharide (LPS)...

article

Roquinimex-mediated protection effect on the development of chronic graft-versus-host disease in mice is associated with induction of Th1 cytokine production and inhibition of proinflammatory cytokine production

Zhi-Yong Xiao, Wen-Xia Zhou, Yong-Xiang Zhang, Jun-Ping Cheng, more

Life Sciences > 2007 > 81 > 19-20 > 1403-1410

Roquinimex is an immunomodulator that can effectively inhibit the development of several autoimmune diseases in animal models, but the mechanism is still unknown. In this study, we investigated the effect of roquinimex on chronic graft-versus-host disease (GVHD) in mice, a well-established model for human systemic lupus erythematosus (SLE). Oral administration of roquinimex significantly suppressed...

article

Observation of the 7 ¹ Π g State of Na ₂ by Optical−Optical Double Resonance Spectroscopy

Chanchal Chaudhuri, Ray-Yuan Chang, Wei-Xiang Chen, Wei-Chia Fang, more

The Journal of Physical Chemistry A > 2007 > 111 > 39 > 9764 - 9768

article

Subchronic toxicity studies of Radix Astragali extract in rats and dogs

Shu-Yi Yu, Hong-Tao OuYang, Ju-Yun Yang, Xiao-Liang Huang, more

Journal of Ethnopharmacology > 2007 > 110 > 2 > 352-355

Radix Astragali extract (RAE) is obtained from Astragalus membranaceus. It consists of Astragalus polysaccharide and Astragalus membranaceus saponins. In the study, we observed the subchronic toxicity of RAE in Sprague–Dawley rats and beagle dogs to evaluate the safety dosage range in clinical application. These subjects were daily administered of RAE by intra-peritoneum or vein for three consecutive...

article

Influence of Carrier Proteins on the Immunologic Response to Haptenic Antitetrodotoxin Vaccine

Qin-Hui Xu, Xiu-Nan Zhao, Jun-Ping Cheng, Chang-Hua Wei, more

Bioconjugate Chemistry > 2006 > 17 > 6 > 1508 - 1513

article

Design, synthesis, and biological evaluation of novel 4-hydro-quinoline-3-carboxamide derivatives as an immunomodulator

Jun-Feng He, Liu-Hong Yun, Ri-Fang Yang, Zhi-Yong Xiao, more

Bioorganic & Medicinal Chemistry Letters > 2005 > 15 > 12 > 2980-2985

A series of novel quinoline-3-carboxamide derivatives were synthesized and evaluated for their immunomodulatory activity. The compounds were tested in vitro for effects on spleen lymphocyte proliferation and TNF-α production by macrophage. Three compounds showed immunomodulatory profiles similar to and more potent than those of linomide and FR137316 and were selected for further pharmacological studies...

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