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Activated astrocytes have been identified as the main source of the serine protease inhibitor α 1 -antichymotrypsin (ACT), an acute phase protein that is tightly associated with amyloid plaques in Alzheimer's disease (AD) and in normal aged human and monkey brain. We analyzed the synthesis of ACT by cultured murine astrocytes in vitro. The murine astrocytes expressed an ACT-like antigen...
A cDNA encoding the rat endopeptidase 24.15 was used to determine the chromosomal localization of the respective human gene. Hybridization to DNA from human–rodent somatic cell hybrids assigned the human gene to chromosome 19. Fluorescencein situhybridization on human metaphase chromosomes localized the human endopeptidase 24.15 to 19q13.3.
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