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The objectives of this study were, first, to prepare 6-bromo-3-n-butylphthalide self-nanoemulsifying system (6-BBP-SNES); and second, to enhance the water solubility and oral bioavailability of 6-BBP. Pseudo-ternary phase diagram was constructed to identify an efficient self-emulsification region. Then, formulations were optimized by assessing the globule size and polydispersity. The composition of...
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