Search results for: Jianyuan Yin

Items from 1 to 20 out of 23 results

article

Identification of metabolites in plasma related to different biological activities of Panax ginseng and American ginseng

Jihua Liu, Qinghai Dong, Guangguang Du, Jia Wang, more

Rapid Communications in Mass Spectrometry > 36 > 4 > n/a - n/a

Rationale Panax ginseng (PG) and American ginseng (AMG) are both medicinal plants of the Panax genus in the Acanthopanax family. Although PG and AMG have similar components of ginsenosides, there are many differences of their bioactivities. In this study, the biochemical mechanisms of different bioactivities of PG and AMG were explored by researching the differential metabolites in plasma after administration...

article

Ginsenoside Rh2 impedes proliferation and migration and induces apoptosis by regulating NF‐κB, MAPK, and PI3K/Akt/mTOR signaling pathways in osteosarcoma cells

Chenchen Li, Huan Gao, Xuemei Feng, Chuyao Bi, more

Journal of Biochemical and Molecular Toxicology > 34 > 12 > n/a - n/a

Ginsenoside Rh2 is a primary bioactive compound obtained from ginseng that indicated anticancer activities against several malignant tumors. However, previous studies have reported little about the inhibitory effect of Rh2 on osteosarcoma (OS). This study aims to explore whether Rh2 could exert anticancer effects in OS cells and further investigate the proliferation, migration, and apoptosis mechanisms...

article

Different absorption and metabolism of ginsenosides after the administration of total ginsenosides and decoction of Panax ginseng

Jihua Liu, Ting Li, Jia Wang, Chunfang Zhao, more

Rapid Communications in Mass Spectrometry > 34 > 13 > n/a - n/a

Rationale Panax ginseng C.A. Meyer (PG), which contains polysaccharides and ginsenosides as the major bioactive components, has been used to promote health and treat diseases for thousands of years in China. Total ginsenosides were extracted from a decoction of Panax ginseng (GD), which included both ginsenosides and polysaccharides, and dissolved in water to obtain a total ginsenosides aqueous solution...

article

Chemical Ingredients Identified from the White SAP of Metaplexis japonica Using UPLC-QTOF/MS

Xiuhua Hao, Ting Li, Lingjun Zhao, Yunhua Wang, more

Chemistry of Natural Compounds > 2019 > 55 > 1 > 164-168

Published in Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2019, pp. 138–141.

article

Guillain-Barre syndrome associated with hemorrhagic fever with renal syndrome in China: a case report

Jie Jiao, Lei Wu, Jianyuan Yin, Xiaojiao Quan, more

BMC Infectious Diseases > 2018 > 18 > 1 > 1-4

Background We describe a case of Guillain-Barre syndrome (GBS) associated with hemorrhagic fever with renal syndrome. To our knowledge, only five cases of GBS associated with Hantavirus infection have been reported so far. Case presentations A 62-year-old man presented intermittent fever, chill and oliguria. According to remarkable leukocytosis, atypical lymphocytes, thrombocytopenia and former...

article

Interaction of the ginsenosides with κ-casein and their effects on amyloid fibril formation by the protein: Multi-spectroscopic approaches

Fanbo Chen, Yunhua Wang, Miao Yang, Jianyuan Yin, more

Journal of Photochemistry and Photobiology B: Biology > 2016 > 160 > C > 306-317

The interaction of the ginsenosides (GS) including ginsenoside Rg₁, Rb₁ and Re with κ-casein and the effects of GS inhibiting amyloid fibril formation by κ-casein have been investigated in vitro by fluorescence and ultraviolet spectra. Results showed that Rg₁ and Rb₁ had dose-dependent inhibitory effects on reduced and carboxymethylated κ-casein (RCMκ-CN) fibril formation, while Re resulted in an...

article

The effects of ginsenosides to amyloid fibril formation by RCMκ-casein

Jihua Liu, Fanbo Chen, Jianyuan Yin, Fengquan Bu, more

International Journal of Biological Macromolecules > 2015 > 79 > Complete > 49-55

When not incorporated into the casein micelle, isolated κ-casein spontaneously forms amyloid fibrils under physiological conditions, and is a convenient model for researching generic aspects of fibril formation. Ginsenosides have recently attracted much research interest because of the effects on aging diseases, which are always associated with amyloid fibril formation, for example, Alzheimer's, Parkinson's,...

article

Interaction of L-arginine with κ-casein and its effect on amyloid fibril formation by the protein: Multi-spectroscopic approaches

Fanbo Chen, Jianyuan Yin, Yunhua Wang, Miao Yang, more

Journal of Photochemistry & Photobiology, B: Biology > 2015 > 143 > Complete > 130-138

Herein, the interaction of l-arginine (ARG) with κ-casein, and its effect on amyloid fibril formation of the protein, have been investigated in vitro by resonance light scattering (RLS), fluorescence, UV–Vis absorption spectroscopy and transmission electron microscopy (TEM) under simulated physiological conditions. The results indicated that ARG inhibited fibril formation by reduced and carboxymethylated...

article

Structural identification of neopanaxadiol metabolites in rats by ultraperformance liquid chromatography/quadrupole‐time‐of‐flight mass spectrometry

Cong Geng, Jianyuan Yin, Xiuhua Yu, Yuxia Yang, more

Rapid Communications in Mass Spectrometry > 29 > 3 > 283 - 294

RATIONALENeopanaxadiol (NPD) is one of the major ginsenosides in Panax ginseng C. A. Meyer (Araliaceae) that has been suggested to be a drug candidate against Alzheimer's disease. However, few data are available regarding its metabolism in rats. METHODSIn this study, a method of ultraperformance liquid chromatography/quadrupole‐time‐of‐flight mass spectrometry (UPLC/QTOFMS) was developed to identify...

article

Structure of Acid Hydrolysate of Total Ginsenosides and Their Cytotoxic Activity

Jingyan Liu, Yuxia Yang, Jianyuan Yin, Jihua Liu, more

Chemistry of Natural Compounds > 2014 > 50 > 4 > 687-690

Bioassay-guided fractionation of the cytotoxic acid hydrolysate of the total ginsenosides of Panax ginseng C. A. Meyer (Araliaceae) afforded a new ginsenoside, (20S,22S)-dammar-22,25-epoxy-3β,12β,20-triol (1), along with five known ginsenosides, 20R,24R-dammar-20(24)-epoxy-3β,12β,25-triol (2), 20R-panaxdiol (3), dammar-(E)-20(22)-ene-3β,12β,25-triol (4), 20R-protopanaxadiol (5), and 20R-dammar-25-ethoxy-3...

article

Determination of arecoline in areca nut based on field amplification in capillary electrophoresis coupled with electrochemiluminescence detection

Qian Xiang, Ying Gao, Bingyan Han, Jing Li, more

Luminescence > 28 > 1 > 50 - 55

A sensitive capillary electrophoresis–electrochemiluminescence (CE–ECL) assay with an ionic liquid (IL) was developed for the determination of arecoline in areca nut. The IL, 1‐butyl‐3‐methylimidazolium tetrafluoroborate (BMImBF₄), was an effective additive improved not only the separation selectivity but also the detection sensitivity of the analyte. BMImBF₄ in the separation electrolyte made the...

article

Validated LC-ESI-MS/MS Method for the Quantitation of Neopanaxadiol: a Novel Neuroprotective Agent from Panax ginseng and Its Application to a Pharmacokinetic Study in Rat Plasma

Cong Geng, Jihua Liu, Qingxiang Guan, Ying Zhang, more

Chromatographia > 2013 > 76 > 9-10 > 509-514

Neopanaxadiol (NPD), a new panaxadiol first obtained from the acid hydrolysate of the total ginsenosides of Panax ginseng C. A. Meyer (Araliaceae) in our laboratory, showed neuroprotective effect against glutamate-induced neurotoxicity in primary cultures of rat cortical cells (Tao et al. Chin Chem Lett 20:687–689, 2009). In this research, a sensitive and specifical method of ultra-performance liquid...

article

Carbon nanotubes-ionic liquid nanocomposites sensing platform for NADH oxidation and oxygen, glucose detection in blood

Lu Bai, Dan Wen, Jianyuan Yin, Liu Deng, more

Talanta > 2012 > 91 > Complete > 110-115

An excellent electrochemical sensing platform has been designed by combining the huge specific surface area of carbon nanotubes (CNTs) and the remarkable conductivity of ionic liquid (IL). IL can easily untangle CNTs bundles and disperse CNTs by itself under grinding condition due to the π–π interaction between CNTs and IL. The resulting nanocomposites showed an augmentation on the voltammetric and...

article

Preparation and pharmacokinetics of solid lipid nanoparticles loaded with pueraria flavones

Qingxiang Guan, Qingtao Guan, Tianmu Lin, Jianyuan Yin

Journal of Controlled Release > 2011 > 152 > S1 > e25-e26

article

Biomolecule-stabilized Au nanoclusters as a fluorescence probe for sensitive detection of glucose

Lihua Jin, Li Shang, Shaojun Guo, Youxing Fang, more

Biosensors and Bioelectronics > 2011 > 26 > 5 > 1965-1969

In this work, biomolecule-stabilized Au nanoclusters were demonstrated as a novel fluorescence probe for sensitive and selective detection of glucose. The fluorescence of Au nanoclusters was found to be quenched effectively by the enzymatically generated hydrogen peroxide (H ₂ O ₂ ). By virtue of the specific response, the present assay allowed for the selective determination of glucose...

article

Solid-State Probe Based Electrochemical Aptasensor for Cocaine: A Potentially Convenient, Sensitive, Repeatable, and Integrated Sensing Platform for Drugs

Yan Du, Chaogui Chen, Jianyuan Yin, Bingling Li, more

Analytical Chemistry > 2010 > 82 > 4 > 1556 - 1563

article

Gold nanoparticle-based near-infrared fluorescent detection of biological thiols in human plasma

Li Shang, Jianyuan Yin, Jing Li, Lihua Jin, more

Biosensors and Bioelectronics > 2009 > 25 > 2 > 269-274

In this work, a new fluorescent method for sensitive detection of biological thiols in human plasma was developed using a near-infrared (NIR) fluorescent dye, FR 730. The sensing approach was based on the strong affinity of thiols to gold and highly efficient fluorescent quenching ability of gold nanoparticles (Au NPs). In the presence of thiols, the NIR fluorescence would enhance dramatically due...

article

Glutathione-capped CdTe quantum dots for the sensitive detection of glucose

Jipei Yuan, Weiwei Guo, Jianyuan Yin, Erkang Wang

Talanta > 2009 > 77 > 5 > 1858-1863

A simple and sensitive assay system for glucose based on the glutathione (GSH)-capped CdTe quantum dots (QDs) was developed. GSH-capped CdTe QDs exhibit higher sensitivity to H ₂ O ₂ produced from the glucose oxidase catalyzed oxidation of glucose, and are also more biocompatible than other thiols-capped QDs. Based on the quenching of H ₂ O ₂ on GSH-capped QDs, glucose...

article

Kinetic study of prolidase activity in erythrocytes against different substrates using capillary electrophoresis with electrochemiluminescence detection

Lingling Zhou, Jipei Yuan, Jianyuan Yin, Erkang Wang

Journal of Chromatography A > 2008 > 1200 > 2 > 255-259

Capillary electrophoresis (CE) with electrochemiluminescence (ECL) detection was used to explore the kinetics of the enzymatic reaction. The different effects of reaction conditions including the concentration of Mn ²⁺ , incubation temperature and pH on prolidase (PLD, EC 3.4.13.9) activity in erythrocyte lysates against three different substrates, Gly-Pro, Val-Pro and Leu-Pro were investigated...

article

Bis(2,2′-bipyridine)(5,6-epoxy-5,6-dihydro-[1,10] phenanthroline)ruthenium: Synthesis and Electrochemical and Electrochemiluminescence Characterization

Hui Wei, Jianyuan Yin, Erkang Wang

Analytical Chemistry > 2008 > 80 > 14 > 5635 - 5639

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Search results for: Jianyuan Yin

Identification of metabolites in plasma related to different biological activities of Panax ginseng and American ginseng

Ginsenoside Rh2 impedes proliferation and migration and induces apoptosis by regulating NF‐κB, MAPK, and PI3K/Akt/mTOR signaling pathways in osteosarcoma cells

Different absorption and metabolism of ginsenosides after the administration of total ginsenosides and decoction of Panax ginseng

Chemical Ingredients Identified from the White SAP of Metaplexis japonica Using UPLC-QTOF/MS

Guillain-Barre syndrome associated with hemorrhagic fever with renal syndrome in China: a case report

Interaction of the ginsenosides with κ-casein and their effects on amyloid fibril formation by the protein: Multi-spectroscopic approaches

The effects of ginsenosides to amyloid fibril formation by RCMκ-casein

Interaction of L-arginine with κ-casein and its effect on amyloid fibril formation by the protein: Multi-spectroscopic approaches

Structural identification of neopanaxadiol metabolites in rats by ultraperformance liquid chromatography/quadrupole‐time‐of‐flight mass spectrometry

Structure of Acid Hydrolysate of Total Ginsenosides and Their Cytotoxic Activity

Determination of arecoline in areca nut based on field amplification in capillary electrophoresis coupled with electrochemiluminescence detection

Validated LC-ESI-MS/MS Method for the Quantitation of Neopanaxadiol: a Novel Neuroprotective Agent from Panax ginseng and Its Application to a Pharmacokinetic Study in Rat Plasma

Carbon nanotubes-ionic liquid nanocomposites sensing platform for NADH oxidation and oxygen, glucose detection in blood

Preparation and pharmacokinetics of solid lipid nanoparticles loaded with pueraria flavones

Biomolecule-stabilized Au nanoclusters as a fluorescence probe for sensitive detection of glucose

Solid-State Probe Based Electrochemical Aptasensor for Cocaine: A Potentially Convenient, Sensitive, Repeatable, and Integrated Sensing Platform for Drugs

Gold nanoparticle-based near-infrared fluorescent detection of biological thiols in human plasma

Glutathione-capped CdTe quantum dots for the sensitive detection of glucose

Kinetic study of prolidase activity in erythrocytes against different substrates using capillary electrophoresis with electrochemiluminescence detection

Bis(2,2′-bipyridine)(5,6-epoxy-5,6-dihydro-[1,10] phenanthroline)ruthenium: Synthesis and Electrochemical and Electrochemiluminescence Characterization

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