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Methanol is the organic solvent closest to water and able to dissolve a huge amount of organic compounds. Therefore, it is a good candidate for pK a determination of drugs sparingly soluble in water or a basic drug presented as a salt which pK a is close to that of its counter-acid. In this work, the acidic dissociation constants in pure methanol of the most common acids used in pharmaceutical...
The acidic dissociation constants in a number of methanol/water mixtures of mono and polycarboxylic acids commonly used in the preparation of drug salts were determined. These solvent mixtures are usually used to determine the pK a of drugs of low aqueous solubility. However, when these drugs are prepared in salt form, the acid–base equilibria of both the basic drug and the counter-anion are...
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