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Common drugs intended for action in plasma (antibacterials, antiallergics, diuretics...) often display both acidic and basic behavior, and some of these amphoteric compounds can appear as zwitterions. In such cases, accurate profiling of lipophilicity vs. pH, which plays a fundamental role in drug pharmacokinetics, might be complex. In the present work two common lipophilicity determination methods...
Two different approaches were evaluated and used to estimate the aqueous pK a values of some flavonols sparingly soluble in water (morin, fisetin and quercetin) from their pK a values in methanol/water mixtures obtained by potentiometry. Both approaches lead to similar results, although one of them requires only one pK a value at one unique methanol/water mixture, whereas the...
Methanol is the organic solvent closest to water and able to dissolve a huge amount of organic compounds. Therefore, it is a good candidate for pK a determination of drugs sparingly soluble in water or a basic drug presented as a salt which pK a is close to that of its counter-acid. In this work, the acidic dissociation constants in pure methanol of the most common acids used in pharmaceutical...
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