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In this paper the validation of pK a determination in MDM–water mixtures is presented. The MDM–water mixture is a new multicomponent cosolvent mixture (consisting of equal volumes of methanol, dioxane and acetonitrile, as organic solvents) that dissolves a wide range of poorly water-soluble compounds. The cosolvent dissociation constants (p s K a ) of 50 chemically diverse...
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