Search results for: Paula Vanninen

Items from 1 to 20 out of 21 results

article

Glutathione conjugation of nitrogen mustards: In vitro study

Nurhazlina Hamzah, Matti Kjellberg, Paula Vanninen

Rapid Communications in Mass Spectrometry > 37 > 9 > n/a - n/a

Rationale This paper describes an in vitro study designed to identify metabolic biomarkers resulting from the conjugation of nitrogen mustards (NMs) with glutathione (GSH). The method developed is essential in providing evidence in the event of NM exposure in biomedical samples. Methods The mass spectral characterization of the proposed NMs–GSH conjugates was performed with liquid chromatography...

article

Osmolal and anion gaps after acute self‐poisoning with agricultural formulations of the organophosphorus insecticides profenofos and diazinon: A pilot study

Jeevan Dhanarisi, Tanita Maria Tzotzolaki, Ana‐Mariya D. Vasileva, Matti A. Kjellberg, more

Basic & Clinical Pharmacology & Toxicology > 130 > 2 > 320 - 327

Self‐poisoning with organophosphorus (OP) insecticides is an important means of global self‐harm. The insecticides are formulated with solvents that may also contribute to toxicity. We set up a study to detect changes in osmolal and anion gaps following ingestion of OP insecticides. We recruited consecutive patients admitted to a Teaching Hospital, Sri Lanka, with a history of OP self‐poisoning. The...

article

Quantum mechanical reference spectrum simulation for precursors and degradation products of chemicals relevant to the Chemical Weapons Convention

Harri Koskela, Samir F. de A. Cavalcante, Samim Ahmed, Paula Vanninen

Magnetic Resonance in Chemistry > 59 > 2 > 117 - 137

A selection of acidic, alkaline and neutral degradation products relevant to the Chemical Weapons Convention was studied in wide range of pH conditions to determine their spin systems as well as spectral parameters. The pH dependence of chemical shifts and J couplings was parameterized using Henderson–Hasselbalch‐based functions using dichloromethane as additional shift reference in TSP‐d₄ referenced...

article

Biological toxins of potential bioterrorism risk: Current status of detection and identification technology

Brigitte G. Dorner, Reinhard Zeleny, Kirsi Harju, Jacques-Antoine Hennekinne, more

TrAC Trends in Analytical Chemistry > 2016 > 85 > PB > 89-102

Biological toxins are a heterogeneous group of compounds that share commonalities both with biological and chemical agents. Based on their availability, toxicity, and the lack of medical countermeasures as well as their known history of military research, toxins such as ricin, botulinum neurotoxins, staphylococcal enterotoxins, and saxitoxin are classified as toxins of bioterrorism risk. At the same...

article

Chemical Munitions Search & Assessment—An evaluation of the dumped munitions problem in the Baltic Sea

Jacek Bełdowski, Zygmunt Klusek, Marta Szubska, Raisa Turja, more

Deep Sea Research Part II: Topical Studies in Oceanography > 2016 > 128 > C > 85-95

Chemical Munitions Search & Assessment (CHEMSEA) project has performed studies on chemical weapon (CW) detection, sediment pollution and spreading as well as biological effects of chemical warfare agents (CWAs) dumped in the Baltic Sea. Results suggest that munitions containing CWAs are more scattered on the seafloor than suspected, and previously undocumented dumpsite was discovered in Gdansk...

article

Arsenic concentrations in Baltic Sea sediments close to chemical munitions dumpsites

Jacek Bełdowski, Marta Szubska, Emelyan Emelyanov, Galina Garnaga, more

Deep Sea Research Part II: Topical Studies in Oceanography > 2016 > 128 > C > 114-122

In addition to natural sources and land-originated pollution, the Baltic Sea has another anthropogenic source of arsenic in bottom sediments—arsenic-based Chemical Warfare Agents (CWA). To examine the potential usage of arsenic contents results for monitoring the leakage from chemical weapons, sediment samples were collected from officially reported and potential chemical weapon dumpsites located...

article

Identification of gymnodimine D and presence of gymnodimine variants in the dinoflagellate Alexandrium ostenfeldii from the Baltic Sea

Kirsi Harju, Harri Koskela, Anke Kremp, Sanna Suikkanen, more

Toxicon > 2016 > 112 > C > 68-76

Gymnodimines are lipophilic toxins produced by the marine dinoflagellates Karenia selliformis and Alexandrium ostenfeldii. Currently four gymnodimine analogues are known and characterized. Here we describe a novel gymnodimine and a range of gymnodimine related compounds found in an A. ostenfeldii isolate from the northern Baltic Sea. Gymnodimine D (1) was extracted and purified from clonal cultures,...

article

Comparison of in vitro metabolism and cytotoxicity of capsaicin and dihydrocapsaicin

Mia Halme, Maija Pesonen, Heta Salo, Martin Söderström, more

Journal of Chromatography B > 2016 > 1009-1010 > C > 17-24

Capsaicin and dihydrocapsaicin are the major active components in pepper spray products, which are widely used for law enforcement and self-protection. The use of pepper sprays, due to their irreversible and other health effects has been under a strong debate. In this study, we compared metabolism and cytotoxicity of capsaicin and dihydrocapsaicin using human and pig liver cell fractions and human...

article

Application of comprehensive NMR‐based analysis strategy in annotation, isolation and structure elucidation of low molecular weight metabolites of Ricinus communis seeds

Ivan Vučković, Marja‐Leena Rapinoja, Matti Vaismaa, Paula Vanninen, more

Phytochemical Analysis > 27 > 1 > 64 - 72

IntroductionPowder‐like extract of Ricinus communis seeds contain a toxic protein, ricin, which has a history of military, criminal and terroristic use. As the detection of ricin in this “terrorist powder” is difficult and time‐consuming, related low mass metabolites have been suggested to be useful for screening as biomarkers of ricin. ObjectiveTo apply a comprehensive NMR‐based analysis strategy...

article

Analysis of nitromethane from samples exposed in vitro to chloropicrin by stable isotope dilution headspace gas chromatography with mass spectrometry

Mia Halme, Maija Pesonen, Toni Grandell, Matti Kuula, more

Journal of Separation Science > 38 > 19 > 3383 - 3389

Chloropicrin (trichloronitromethane) is a widely used soil fumigant and an old chemical warfare agent. The metabolism of chloropicrin is not well known in mammals but nitromethane has been shown to be one of its main metabolites. Here, a fast and simple headspace gas chromatography with mass spectrometry method was applied for the measurement of nitromethane from aqueous samples. The analytical method...

article

Applying human and pig hepatic in vitro experiments for sulfur mustard study: Screening and identification of metabolites by liquid chromatography/tandem mass spectrometry

Mia Halme, Maija Pesonen, Ullastiina Hakala, Markku Pasanen, more

Rapid Communications in Mass Spectrometry > 29 > 14 > 1279 - 1287

Rationale Sulfur mustard is a chemical warfare agent (CWA) with high toxicity and complex metabolism. This study aimed at identification of new metabolic biomarkers for sulfur mustard using in in vitro exposures and various mass spectrometric techniques. Methods Human and pig liver subcellular fractions were used as biocatalysts. Metabolites were screened by liquid chromatography and tandem mass...

article

Verification and quantification of saxitoxin from algal samples using fast and validated hydrophilic interaction liquid chromatography–tandem mass spectrometry method

Mia Halme, Marja-Leena Rapinoja, Maaret Karjalainen, Paula Vanninen

Journal of Chromatography B > 2012 > 880 > Complete > 50-57

Hydrophilic interaction liquid chromatography–tandem mass spectrometry (HILIC–MS/MS) method was validated with algal samples for verification and quantification of saxitoxin (STX), a potent neurotoxin which is listed in the Chemical Weapons Convention (CWC) in Schedule 1A. Isocratic elution, conventional bore HILIC column and high flow rate together with accurate post-column splitter provided detection...

article

Development and validation of efficient stable isotope dilution LC–HESI–MS/MS method for the verification of β-lyase metabolites in human urine after sulfur mustard exposure

Mia Halme, Maaret Karjalainen, Harri Kiljunen, Paula Vanninen

Journal of Chromatography B > 2011 > 879 > 13-14 > 908-914

As a part of the project for screening unequivocal biomarkers after sulfur mustard exposure, a quantitative method for the determination of β-lyase metabolites 1,1′-sulfonylbis-[2-(methylsulfinyl)ethane] (SBMSE) and 1-methylsulfinyl-2-[2-(methylthio)ethylsulfonyl]ethane (MSMTESE) was validated. Full validation was conducted according to the FDA guidelines for method validation using pooled human urine...

article

Evaluation of a chemical munition dumpsite in the Baltic Sea based on geophysical and chemical investigations

Tine Missiaen, Martin Söderström, Irina Popescu, Paula Vanninen

Science of the Total Environment > 2010 > 408 > 17 > 3536-3553

This paper discusses the results of geophysical and chemical investigations carried out in a chemical munition dumpsite in the southern Baltic Sea, east of the island of Bornholm. After WW2 over 32,000tons of chemical war material was dumped here including shells and bombs as well as small drums and containers. The geophysical investigations combined very-high-resolution seismics and gradiometric...

article

Structural Characterization of Chemical Warfare Agent Degradation Products in Decontamination Solutions with Proton Band-Selective ¹ H− ³¹ P NMR Spectroscopy

Harri Koskela, Ullastiina Hakala, Paula Vanninen

Analytical Chemistry > 2010 > 82 > 12 > 5331 - 5340

article

Environmental Hazards of Sea-Dumped Chemical Weapons

Hans Sanderson, Patrik Fauser, Marianne Thomsen, Paula Vanninen, more

Environmental Science & Technology > 2010 > 44 > 12 > 4389 - 4394

article

On-Flow Pulsed Field Gradient Heteronuclear Correlation Spectrometry in Off-Line LC−SPE−NMR Analysis of Chemicals Related to the Chemical Weapons Convention

Harri Koskela, Mia Ervasti, Heikki Björk, Paula Vanninen

Analytical Chemistry > 2009 > 81 > 3 > 1262 - 1269

article

Application of a Microcoil Probe Head in NMR Analysis of Chemicals Related to the Chemical Weapons Convention

Harri Koskela, Paula Vanninen

Analytical Chemistry > 2008 > 80 > 14 > 5556 - 5564

article

Determination of Trace Amounts of Chemical Warfare Agent Degradation Products in Decontamination Solutions with NMR Spectroscopy

Harri Koskela, Marja-Leena Rapinoja, Marja-Leena Kuitunen, Paula Vanninen

Analytical Chemistry > 2007 > 79 > 23 > 9098 - 9106

article

Screening and Identification of Organophosphorus Compounds Related to the Chemical Weapons Convention with 1D and 2D NMR Spectroscopy

Harri Koskela, Nicoleta Grigoriu, Paula Vanninen

Analytical Chemistry > 2006 > 78 > 11 > 3715 - 3722

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INFONA - science communication portal

Search results for: Paula Vanninen

Glutathione conjugation of nitrogen mustards: In vitro study

Osmolal and anion gaps after acute self‐poisoning with agricultural formulations of the organophosphorus insecticides profenofos and diazinon: A pilot study

Quantum mechanical reference spectrum simulation for precursors and degradation products of chemicals relevant to the Chemical Weapons Convention

Biological toxins of potential bioterrorism risk: Current status of detection and identification technology

Chemical Munitions Search & Assessment—An evaluation of the dumped munitions problem in the Baltic Sea

Arsenic concentrations in Baltic Sea sediments close to chemical munitions dumpsites

Identification of gymnodimine D and presence of gymnodimine variants in the dinoflagellate Alexandrium ostenfeldii from the Baltic Sea

Comparison of in vitro metabolism and cytotoxicity of capsaicin and dihydrocapsaicin

Application of comprehensive NMR‐based analysis strategy in annotation, isolation and structure elucidation of low molecular weight metabolites of Ricinus communis seeds

Analysis of nitromethane from samples exposed in vitro to chloropicrin by stable isotope dilution headspace gas chromatography with mass spectrometry

Applying human and pig hepatic in vitro experiments for sulfur mustard study: Screening and identification of metabolites by liquid chromatography/tandem mass spectrometry

Verification and quantification of saxitoxin from algal samples using fast and validated hydrophilic interaction liquid chromatography–tandem mass spectrometry method

Development and validation of efficient stable isotope dilution LC–HESI–MS/MS method for the verification of β-lyase metabolites in human urine after sulfur mustard exposure

Evaluation of a chemical munition dumpsite in the Baltic Sea based on geophysical and chemical investigations

Structural Characterization of Chemical Warfare Agent Degradation Products in Decontamination Solutions with Proton Band-Selective ¹ H− ³¹ P NMR Spectroscopy

Environmental Hazards of Sea-Dumped Chemical Weapons

On-Flow Pulsed Field Gradient Heteronuclear Correlation Spectrometry in Off-Line LC−SPE−NMR Analysis of Chemicals Related to the Chemical Weapons Convention

Application of a Microcoil Probe Head in NMR Analysis of Chemicals Related to the Chemical Weapons Convention

Determination of Trace Amounts of Chemical Warfare Agent Degradation Products in Decontamination Solutions with NMR Spectroscopy

Screening and Identification of Organophosphorus Compounds Related to the Chemical Weapons Convention with 1D and 2D NMR Spectroscopy

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